DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smid and ATAD3B

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	XP_011540546.1	Gene:	ATAD3B / 83858	HGNCID:	24007	Length:	696	Species:	Homo sapiens

Alignment Length:	619	Identity:	133/619 - (21%)
Similarity:	232/619 - (37%)	Gaps:	161/619 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   403 DP-GLRRIGRFDHEI--------AIHIPSRK------ERREILRIQCEGLSV------------- 439
            || ||.|..:...|:        |:::...:      |::..|::|.|.|::
Human    51 DPTGLERAAKAARELEHSRYAKEALNLAQMQEQTLQLEQQSKLKMQLEALNLLHTLVWARSLCRA 115

  Fly   440 -----DPKLNYDKIAELTPGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVTLDDD 499
                 ..:|:.....|..|   ..:..||....|:|     ...|..::.|.:|:...|::   :
Human   116 GAVQTQERLSGSASPEQVP---AGECCALQEYEAAV-----EQLKSEQIRAQAEERRKTLS---E 169

  Fly   500 EPSEDAGETPVPDS----------------------KGEETAKDAEAEQKVDGDKETSAKDKSEG 542
            |..:........|.                      |.||:.:..||.::...::|...:.|:|
Human   170 ETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNE- 233

  Fly   543 DSPNIETPKKATNGNSSIKSPQKTPKKSAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYY 607
             ...:||..:|.             .|:..:..|...:...:...|.::.|.:.:.::.:  .:.
Human   234 -MLRVETEARAR-------------AKAERENADIIREQIRLKASEHRQTVLESIRTAGT--LFG 282

  Fly   608 EPTLAELTNFLDNPPEEFADPNFCLTLIDFVDAIKVMQPSAKREGFITVPDTTWDDIGALEKIRE 672
            |...|.:|: .|......|.    |||: .|........:|....||..      .:|....:||
Human   283 EGFRAFVTD-RDKVTATVAG----LTLL-AVGVYSAKNATAVTGRFIEA------RLGKPSLVRE 335

  Fly   673 ELKLAVLAPVKYPEMLERLGLTAPSGV----------------------------------LLCG 703
            ..::.||..:::|..:.|..|:.|..|                                  ||.|
Human   336 TSRITVLEALRHPIQVSRRLLSRPQDVLEGVVLSPSLEARVRDIAIATRNTKKNRGLYRHILLYG 400

  Fly   704 PPGCGKTLLAKAIANEAGINFISVKGPELMNMYVG-ESERAVRACFQRARNS-APCVIFFDEFDS 766
            |||.||||.||.:|..:|:::..:.|.::..|  | |...|:...|..|..| ...::|.||.|:
Human   401 PPGTGKTLFAKKLALHSGMDYAIMTGGDVAPM--GREGVTAMHKLFDWANTSRRGLLLFMDEADA 463

  Fly   767 LCPKRSDGGDGNNSGTRIVNQLLTEMDGVEERKGVYILAATNRPDIIDPAILRPGRLDTILYVGF 831
            ...||:. .:.:......:|..|..| |....|.:.:| |:|.|:..|.||  ..|:|.:::...
Human   464 FLRKRAT-EEISKDLRATLNAFLYHM-GQHSNKFMLVL-ASNLPEQFDCAI--NSRIDVMVHFDL 523

  Fly   832 PEQSERTE---------ILKATTKNGKRPVLADDVD----LDEIAAQTEGYTGADLAGLVK--QA 881
            |:|.||..         :||..|: |||.:.....|    ..|:|..|||.:|.::|.|..  ||
Human   524 PQQEERERLVRLHFDNCVLKPATE-GKRRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQA 587

  Fly   882 SMFSLRQSLNNGDTNLDDLCVRSQHFQEALQQLR 915
            :.::.:..:..  ..:.|.||     |:|:||.|
Human   588 TAYASKDGVLT--EAMMDACV-----QDAVQQYR 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	133/619 (21%)
		AAA	287..418	CDD:278434	6/23 (26%)
		P-loop_NTPase	679..>716	CDD:304359	18/70 (26%)
		AAA	699..830	CDD:278434	43/166 (26%)
ATAD3B	XP_011540546.1	DUF3523	42..334	CDD:288859	53/322 (16%)
		GBP_C	<142..227	CDD:303769	14/92 (15%)
		coiled coil	199..210	CDD:293879	2/10 (20%)
		26Sp45	246..604	CDD:130309	89/381 (23%)
		AAA	396..523	CDD:278434	42/133 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910