DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and PEX1

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_196464.2	Gene:	PEX1 / 830746	AraportID:	AT5G08470	Length:	1130	Species:	Arabidopsis thaliana

Alignment Length:	1005	Identity:	244/1005 - (24%)
Similarity:	383/1005 - (38%)	Gaps:	307/1005 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 SRRKFGPFRQLVHQAFSIISESYNLDKVSSSE-------------EDC-VSEDSEPPP------- 90
            |..|..|.:.::...||.::...:|..|.|..             ..| |:||.|.|.
plant   286 SSAKKEPRQAILRLVFSDLAAKGHLMMVESLRLYLGAGLHSWVYLRGCNVNEDKEIPALSLSPCV 350

  Fly    91 -------------TNSVMNNMMNSLYSQPRKPLAPKPISEPIDI--------------SSG--DE 126
                         |:.:.||......|.|     |..:|..:|:              |.|  ||
plant   351 FKISENEKVLDKGTDRLGNNNSVRKSSHP-----PSGLSTYVDVVDWSVHDKVVTALSSEGLHDE 410

  Fly   127 NEDDSNTKTTNGDGVAAAAAPPPPTPAVQGSALKRL--------MEEVPEIAVAAKKVAKPNTIH 183
            ...|.|.|     |:               ..|.||        |..|..:.|::..|.:....|
plant   411 GNHDKNKK-----GL---------------EYLTRLWSLAQLDAMASVTGVDVSSLIVGRETFFH 455

  Fly   184 VSSSEAIQKLHQVVGNRAKNLSEDAVPRSKDHRNVPGLYQQLHQNQ------------SRDRLRK 236
            . ....::....:.|..:.|...::..:.| |..:..||.....::            |.||..|
plant   456 F-EVRGLESYKSIDGQPSVNDRWESGKKDK-HTPLEILYVMTVSDESLLGDKFAGYDLSLDRSEK 518

  Fly   237 FKRDLEVQHPTESFR---------------------DIGG---MDSTLKELCEMLIHIKSPE--F 275
            ....:.::...|...                     ||..   |...:.::.:.:..:.||.  .
plant   519 SDNVVHIEPVLEKMNLGEPIYLKSAKETHCNKGVSPDISSLTWMGPIVSDVIKRMTVLLSPAAGM 583

  Fly   276 YFQLGLLPSRG-LLLHGPPGCGKTFLARAISGQLKMPLMEIPATELIGGISGESEERIR------ 333
            :|....:||.| :|::||||.|||.||||.:...: ...::.|..::...|..:.|:::
plant   584 WFSKFKIPSPGHILIYGPPGSGKTILARAAAKYFE-EQKDLLAHVILVSCSTLALEKVQHIHHVL 647

  Fly   334 -EVFDQAIGYSPCVLFIDEIDAI-------GGNRQWASKDMERRIVSQLISSLDNLKANEFGQSV 390
             .|..:.:.::|.|:.:|::|:|       .|.:......|..:.::.:|......:.:..|...
plant   648 SSVIAEGLEHAPSVIILDDLDSIISSSSDTEGTQASVGVTMLTKFLTDVIDDYGEYRNSSCGIGP 712

  Fly   391 VVIAATTRP-DVLDPGLRRIGRFDHEIAIHIPSRKERREILR-------IQCEGLSVDPKLNYDK 447
            :...|:.:. :.:...|...||||..:.:..|:..||..||:       :.|   |.|..||
plant   713 LAFVASVQSLEQIPQTLSSSGRFDFHVQLAAPATSERGAILKHEIQKRLLDC---SEDILLN--- 771

  Fly   448 IAELTPGYVGADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVTLDDDEPSEDAGETPVPD 512
            :|....||...||..||.||...|:.|         |...|.|::...|..::
plant   772 LAAKCEGYDAYDLEILVDRAVHAAIGR---------HLPLESNISKYNLVKED------------ 815

  Fly   513 SKGEETAKDAEAEQKVDGDKETSAKDKSEGDSPNIETPKKATNGNSSIKSPQKTPKKSAEKPTDA 577

plant   816 ----------------------------------------------------------------- 815

  Fly   578 AMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEFADPNFCLTLIDFVD-AI 641
                                                                |...:.|||. |:
plant   816 ----------------------------------------------------FTRAMHDFVPVAM 828

  Fly   642 KVMQPSAKREGFITVPDTTWDDIGALEKIREELKLAVLAPVKYPEMLERLGLTAPSGVLLCGPPG 706
            :.:..||...|.:     .|:|:|.:..|:..:|..:..|.|:|::..:..|...|.|||.||||
plant   829 RDITKSASEGGRL-----GWEDVGGVTDIKNAIKEMIELPSKFPKIFAKSPLRLRSNVLLYGPPG 888

  Fly   707 CGKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRACFQRARNSAPCVIFFDEFDSLCPKR 771
            ||||.:..|.|....:.|||||||||:|.|:|.||:|||..|.:|..:|||::|||||||:.|||
plant   889 CGKTHIVGAAAAACSLRFISVKGPELLNKYIGASEQAVRDIFSKAAAAAPCILFFDEFDSIAPKR 953

  Fly   772 SDGGDGNNSGTRIVNQLLTEMDGVEERKGVYILAATNRPDIIDPAILRPGRLDTILYVGFPEQSE 836
              |.|......|:|||.|||:||||...||::.|||:|||::|||:|||||||.:|...||...|
plant   954 --GHDNTGVTDRVVNQFLTELDGVEVLTGVFVFAATSRPDLLDPALLRPGRLDRLLLCDFPSPPE 1016

  Fly   837 RTEILKATTKNGKRPVLADDVDLDEIAAQTEGYTGADLAGLVKQASMFSLRQSLNNGD---TNLD 898
            |.|||   |...::.::|||:||:.||..|||::||||..|:..|.:.::.:.||..|   |...
plant  1017 RLEIL---TVLSRKLLMADDIDLEPIALMTEGFSGADLQALLSDAQLAAVHEYLNREDKPETGTT 1078

  Fly   899 DLCVRSQHFQEALQQLRPSVNEQDR-KIYD 927
            .: :.....:....:.:|||:|.:: |:||
plant  1079 PI-ITDPLLKSIASKTKPSVSETEKQKLYD 1107

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330	5/23 (22%)
		SpoVK	271..919	CDD:223540	187/676 (28%)
		AAA	287..418	CDD:278434	31/145 (21%)
		P-loop_NTPase	679..>716	CDD:304359	16/36 (44%)
		AAA	699..830	CDD:278434	77/130 (59%)
PEX1	NP_196464.2	PEX-1N	109..182	CDD:286361
		SpoVK	585..1104	CDD:223540	187/674 (28%)
		AAA	589..>635	CDD:99707	17/46 (37%)
		AAA	881..1010	CDD:278434	77/130 (59%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000137
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810