DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and FtsHi1

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_567691.1	Gene:	FtsHi1 / 828494	AraportID:	AT4G23940	Length:	946	Species:	Arabidopsis thaliana

Alignment Length:	765	Identity:	189/765 - (24%)
Similarity:	292/765 - (38%)	Gaps:	247/765 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   375 ISSLDNLKANEFGQSVVVIAATTRPDVLDPGLRRIGRFDHEIAIHIPSRKE---RREILR----I 432
            ::|:||           |.:..||..:.:...|.|  ..|.......:|.:   |..|||    :
plant     1 MASIDN-----------VFSLGTRFSIPENPKRSI--LKHATTSSFSARTQTRWRAPILRRSFTV 52

  Fly   433 QCE---GLSVDPKLNYDKIA-------------ELTPGY-VGADLMALVSR--------AASVA- 471
            .||   |.|...:.|....|             ::.|.| ||..|..|..|        ||:.|
plant    53 LCELKTGSSSSGETNNSPAADDFVTRVLKENPSQVEPRYRVGDKLYNLKEREDLSKGTNAATGAF 117

  Fly   472 --VKRR--SMKKFRELHAASEKNMTTVTLDDDEPSEDAGETPVPDSK-GEETAKDAEAEQKVDGD 531
              :||:  |.||     ..::|:..:|.| .|...|..|:..||:.. |.|.:::.|.|:.|...
plant   118 EFIKRKFDSKKK-----TETDKSEESVYL-SDILREYKGKLYVPEQVFGPELSEEEEFEKNVKDL 176

  Fly   532 KETSAKD---KSEGDSPNIETPKKA-----TNGN----------SSIKSPQKTPKKSAEKPTDAA 578
            .:.|.:|   ..|.|...:.|.|:.     |:|.          ..:||.|:|
plant   177 PKMSLEDFRKAMENDKVKLLTSKEVSGVSYTSGYRGFIVDLKEIPGVKSLQRT------------ 229

  Fly   579 MDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEFAD-PN------------- 629
                       |.:::.||..:.:..:.|.....|:...:.:...:.|| ||
plant   230 -----------KWSMKLEVGEAQALLKEYTGPQYEIERHMTSWVGKVADFPNPVASSISSRVMVE 283

  Fly   630 -----------------------FCLTLIDFVDAIKVMQPSAKR------EGFITVPDTTWD--- 662
                                   |.:|...||..:.|:.|.||.      ..|:.|.:.:||
plant   284 LGMVTAVIAAAAVVVGGFLASAVFAVTSFAFVTTVYVVWPIAKPFLKLFVGVFLGVLEKSWDYIV 348

  Fly   663 ----------------------------------------------------------------- 662

plant   349 DVLADGGIFSRISDFYTFGGVASSLEMLKPILLVVMTMVLLVRFTLSRRPKNFRKWDLWQGIAFS 413

  Fly   663 -----------------DIGALEKIREELKLAVLAPVKYPEMLERLGLTAPSGVLLCGPPGCGKT 710
                             |:..:::..:||: .::..:|.|::.:::|:..|.||||.||||||||
plant   414 QSKAEARVDGSTGVKFADVAGIDEAVDELQ-ELVKYLKNPDLFDKMGIKPPHGVLLEGPPGCGKT 477

  Fly   711 LLAKAIANEAGINFISVKGPELMNMYVGESERAVRACFQRARNSAPCVIFFDEFDSLCPKRSDGG 775
            |:|||||.|||:.|..:.|.|.:.:.||.....:|..|:||:.:.|.|||.||.|:|..:|....
plant   478 LVAKAIAGEAGVPFYQMAGSEFVEVLVGVGSARIRDLFKRAKVNKPSVIFIDEIDALATRRQGIF 542

  Fly   776 DGN-----NSGTR----IVNQLLTEMDGVEERKGVYILAATNRPDIIDPAILRPGRLDTILYVGF 831
            ..|     |:.|:    .:||||.|:||.:..|||..|.||||.|::|||:|||||.|..:.|..
plant   543 KENSDQLYNAATQERETTLNQLLIELDGFDTGKGVIFLGATNRRDLLDPALLRPGRFDRKIRVRP 607

  Fly   832 PEQSERTEILKATTKNGKRPVLADDVDLDEIAAQTEGYTGADLAGLVKQASMFSLRQSLN----- 891
            |....|.:|||......|   ::|.|||...|:...|::||.||.||::|::.::|::.|
plant   608 PNAKGRLDILKIHASKVK---MSDSVDLSSYASNLPGWSGAKLAQLVQEAALVAVRKTHNSILQS 669

  Fly   892 NGDTNLDDLCVRSQHFQEAL---QQLRPSVNEQDRKIYDKLRLKYAAPRV 938
            :.|..:|.|.|........|   .|.|.:..|....|...|.|:|...::
plant   670 DMDDAVDRLTVGPTRIGLELGHQGQCRRATTEVGVAITSHLLLRYENAKI 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	184/744 (25%)
		AAA	287..418	CDD:278434	9/42 (21%)
		P-loop_NTPase	679..>716	CDD:304359	19/36 (53%)
		AAA	699..830	CDD:278434	66/139 (47%)
FtsHi1	NP_567691.1	FtsH_fam	373..899	CDD:273520	108/351 (31%)
		AAA	466..606	CDD:278434	66/139 (47%)
		Peptidase_M41	701..895	CDD:279742	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910