Protein Alignment smid and DRC11

DIOPT Version :10

• Sequence 1: NP_523959.2
• Gene: smid / 38824
• FlyBaseID: FBgn0016983
• Length: 944
• Species: Drosophila melanogaster
• Sequence 2: NP_001257514.1
• Gene: DRC11 / 79781
• HGNCID: 26195
• Length: 830
• Species: Homo sapiens
• Alignment Length: 845
• Identity: 158/845 - (18%)
• Similarity: 291/845 - (34%)
• Gaps: 248/845 - (29%)

  Fly   216 RNVPGLYQQLHQNQSRDRLRKFKRDLEVQHPTESFRDIGGMDSTLKELCEMLIHIKSPEFYF--- 277
            ||:..:|.|....|.|..:||.               :.|:...:.||...::.::..||::
Human    61 RNLENVYDQFVHPQKRILIRKV---------------LDGVMGRILELKNEMVELELTEFHYFDD 110

  Fly   278 ---QLGLLPSRGLLLHGPPGCGKTFLARAI--------------------SGQLKMPLMEIP--- 316
               .|.|.|.:   |..|  ..|.||...:                    :..:|.|:..||
Human   111 ILQDLKLAPQQ---LDIP--IPKYFLKEKLEVIKGREKILAQILADSGIDTSDMKYPVKSIPFDE 170

  Fly   317 ATELIGGISGESEERIREVFDQAIGYSPCVLFIDEIDAIGGNRQWASKDMERRIVSQLISSL--- 378
            |.:||.......:.|:|.:|.:.|       ::.|.      |...||.:.:::.....::|
Human   171 AVKLIQIAERARQGRLRALFMKQI-------YLQEY------RAKQSKMLGKKVTDTWAAALRIQ 222

  Fly   379 ------------DNLKANE-----------FGQ-SVVVIAATTRPDVLDPGLRRIGRFDHEIAIH 419
                        :.|:..|           |.: |..||.|           .::.|..:|  :.
Human   223 KVWRRFHQRKETEKLREEEMIFLGMNPPPLFNEVSATVIQA-----------EKVDRLRNE--VQ 274

  Fly   420 IPSRKERRE-ILRIQ-----CEGLSVDPKLNYDKI-------AELT---PGYVGADLMALVSRAA 468
            |...::.|| ::.|:     .||:.:...|. |:|       ..||   |.|..      |....
Human   275 IKHEEDYREALVTIKNDLKLIEGVDIKENLQ-DQIRHWFIECRNLTGTFPDYPD------VEEGG 332

  Fly   469 SVAVKRRSMKKFRELHAASEKNMTTVTLDDDEPSEDAGETPVPDSKGEETAKDAEAEQKVDGDKE 533
            |..:             .|:|.:..|..|.....|:..:......|.|:..|.|:.::|  |.||
Human   333 SAII-------------FSDKTIQQVIEDIIANQEEEEKNKKKKKKKEKQPKKAKKQKK--GTKE 382

  Fly   534 TSAKDKSEGD----SPNIETP--------------KKATNGNSS--------------------- 559
               |:|.|.:    ||::..|              ||..:.|.|
Human   383 ---KNKEEDEKWKMSPSLFLPAMKEGCNAYKEIWMKKDESWNFSQDYDPELIKEEKRKELQSEIR 444

  Fly   560 ----------IKSPQKTPKKSAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYEPTLAEL 614
                      :|:.:....:..|:|..|....|.   ::.||..::|..:....|...:.|:..|
Human   445 IQVDELMRQELKNLKLAVDRERERPVKAGKKKDK---KKGKKGKKKEKKAKKDKDLTADRTIESL 506

  Fly   615 TNFLDNPPEEFADPNFCL-----TLIDFVDAIKVMQPSAKREGFITVPDTTWDDIGALEKIREEL 674
            .       :|..:....:     .|.|::.....:..:.::.....:|        :|..:|:.:
Human   507 Y-------KELVEEGLLIQALKVNLSDYIGEYSYLGTTLRQVSIEPMP--------SLLDVRQLI 556

  Fly   675 KLAVLAPVKYPEMLERLGLTAPSGVLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNMYVGE 739
            .|..:.|:....:.|:..|.  ..:||.||.|.||.:|..||..|.|.|..::....:...|.|:
Human   557 TLYGIWPLGSAAVHEKAPLV--KSLLLAGPSGVGKKMLVHAICTETGANLFNLSSSNIAGKYPGK 619

  Fly   740 S--ERAVRACFQRARNSAPCVIFFDEFDSLCPKRSDGGDGNNSGTRIVNQLLTEMDGVEERKGVY 802
            :  :..:.|.|:.||...|.|::.::.:....|:....:..|...|:...|...:..::....:.
Human   620 NGLQMMLHAVFKVARQLQPSVVWIEDTEKTFYKKVPNAEKMNEPKRLKKHLPQILKLLKPDDRIL 684

  Fly   803 ILAATNRPDIIDPAILRPGRL-DTILYVGFPEQSERTEILK-ATTKNGKRPVLADDVDLDEIAAQ 865
            |:..|.||  .|..:....:: ..|:.|..|:.:.|..:.| ...:||  .||...:::..:|..
Human   685 IVGTTRRP--FDAELQSFCKVYQKIILVPRPDYASRYVLWKQIIERNG--GVLTSALNVSCLAKV 745

  Fly   866 TEGYTGADLAGLVKQASMFSLRQSLNNGDTNLDDLCVRSQ--------HFQEALQQLRPSVNEQD 922
            |:|:|...:..:||..               |.|..:|.|        .|..|:..:.|...|::
Human   746 TDGFTQGHIVEVVKGV---------------LTDQRIRRQIHKPLTAVEFITAITSMNPVYKEEE 795

  Fly   923  922
            Human   796  795

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:465247
		CDC48	<242..933	CDD:273521	150/819 (18%)
DRC11	NP_001257514.1	RecA-like_IQCA1	551..710	CDD:410914	36/162 (22%)