DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and Iqca1l

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_001019488.2	Gene:	Iqca1l / 499971	RGDID:	1564789	Length:	822	Species:	Rattus norvegicus

Alignment Length:	781	Identity:	165/781 - (21%)
Similarity:	271/781 - (34%)	Gaps:	194/781 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 YQQLHQNQS-RDRLRKFKRDLEVQHPTESFRDIGGMDSTLKELCEMLIHIKSPEFYFQLGLLPSR 285
            |.||.|..: :.|.:.....|....|..|..::.||..|     |.||.::..|
  Rat   123 YFQLEQTSTMKARQQMLAEILARLEPLASQENLRGMSRT-----EALIIVQCAE----------- 171

  Fly   286 GLLLHGPPGCGKTFLARAISGQLKMPLM-EIPATELIGGISGESEERIREVFDQAIGYSPCVLFI 349
                            ||..|:|:...| ||...|       |.:.||||...|........:.|
  Rat   172 ----------------RARQGRLRATFMREIRKEE-------ERDRRIRENGRQKFSQDQGAIVI 213

  Fly   350 DEI--DAIGGNRQWASKDMERRIVSQLISSLDNLKANEFGQSVV-VIAATTRPDVLDPGLRRIGR 411
            .::  ..:...|....:.||...:..|.||....:.|...|:.| ..:..||....:...:....
  Rat   214 QKVWKGYLQRKRIEQDRRMEMEFIGMLPSSSQTTRQNALAQAFVGEESRRTRQVEKEEEFQEAIA 278

  Fly   412 FDHEIAIHI--PSRKER-REILR---IQCEGLS------VDPKL--NYDKIAELTPGYVGADLMA 462
            ..||.....  |..||| ::.:|   |:|..|:      .|...  :|...|:.||..|..:|.|
  Rat   279 KTHESLTETEGPDMKERMKDQIRQWFIECHALTGRFPDYPDEASGGSYLIFADKTPEQVRQELEA 343

  Fly   463 LV----------SRAASVAVKRRSMKKFRELHA--------------------ASEKNMTTV--- 494
            ..          ::......|.:..||.:|..|                    |..:..|::
  Rat   344 QAQENKKKEQEKNKDKVKEKKEKKKKKTKEEKAKKDPEVMFKVLPSKSIPVINAGHEEFTSIWKS 408

  Fly   495 TLDDDEPSEDAGETPVPDSKGEETAKDAEAEQKVDGDKETSAKDKSEGDSPNIETPKKATNGNSS 559
            ..|:..||:....    ::..||..|..|.|.:|..|:..    :.|..:..:...::.|.
  Rat   409 RYDNKHPSQSFDS----ETLREEKRKQVEMEIRVQVDELM----RQELRNLRLAVDREETR---- 461

  Fly   560 IKSPQKTPKKSAEKPTDAAMDVDNVAPEEPKKAVEQEVDSSSSNDEYYE----------PTLAEL 614
               |.|:|||...|             :..||..|:::....|.|..:|          ..|..|
  Rat   462 ---PLKSPKKKGGK-------------KSGKKKKEKDLTPDRSVDSLFEELVVIGLIKKSLLVTL 510

  Fly   615 TNFLDNPPEEFADPNFCLTLIDFVD-AIKVMQPSAKREGFITVPDTTWDDIGALEKIREELKL-A 677
            .:::.:          ||.|...:. |.|:..||                   |..||:.:.| .
  Rat   511 NDYIGD----------CLYLGSTLTLANKIPMPS-------------------LFDIRQNIALYG 546

  Fly   678 VLAPVKYPEMLERLG-----LTAP--SGVLLCGPPGCGKTLLAKAIANEAGINFISVKGPELMNM 735
            ||          |||     ..||  ..:||.||.|.||.:|.:|:..|.|.|...:....:|..
  Rat   547 VL----------RLGSHDIHTMAPLVRSILLVGPSGMGKKMLVQAVCTETGANLFDLSPGNVMGK 601

  Fly   736 YVGE--SERAVRACFQRARNSAPCVIFFDEFDSLCPKRSDGGDGNNSGTRIVNQLL--TEMDGVE 796
            |.|:  |:..:...|:.||...|.||:....:....|:....:......||...|:  |...|..
  Rat   602 YPGKNGSQLLMHIVFKVARVFQPSVIWIGNTEKTFYKKIPKEERRMDPKRIKKDLMRATRQLGPG 666

  Fly   797 ERKGVYILAATNRPDIID-PAILRPGRLDTILYVGFPEQSERTEILKATTKN-GKRPVLADDVDL 859
            :|  |.::..|.||.:.: ..:.|  ..:.||::..|:.:.|..:.|...:| |........:|:
  Rat   667 DR--VMLIGTTERPQLAEMKGLCR--FYERILFIPRPDYASRYVLWKRMIENQGIGVQQTQSLDI 727

  Fly   860 DEIAAQTEGYTGADLAGLVKQASMFSLRQSLNNGDTNLDDLCVRSQHFQEALQQLRPSVNEQDRK 924
            ..:|..::|||...:...::  |:.:.|:.|     .|....:.:..|...|.:|.|...|::..
  Rat   728 SALARVSDGYTPGHILQSIQ--SVLTERRLL-----QLTKKPLVASEFVVHLAKLDPVYREEEES 785

  Fly   925 I 925
            :
  Rat   786 L 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	150/723 (21%)
		AAA	287..418	CDD:278434	28/134 (21%)
		P-loop_NTPase	679..>716	CDD:304359	14/43 (33%)
		AAA	699..830	CDD:278434	36/135 (27%)
Iqca1l	NP_001019488.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	338..378		7/39 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	457..484		10/46 (22%)
		SpoVK	<563..738	CDD:223540	44/178 (25%)
		AAA	565..698	CDD:278434	36/136 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810