DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment smid and AgaP_AGAP012655

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	XP_001230510.1	Gene:	AgaP_AGAP012655 / 4397685	VectorBaseID:	AGAP012655	Length:	787	Species:	Anopheles gambiae

Alignment Length:	731	Identity:	222/731 - (30%)
Similarity:	336/731 - (45%)	Gaps:	198/731 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 LYQQLHQNQSRDRLRKFKRDLEV---------QHPTE----SFRDIGGMDST---LKELCEMLIH 269
            |..||::...:|||....|..:|         ||..:    |..:|||:|:|   ||||.||...
Mosquito   226 LTDQLNKMSLKDRLYVILRTTKVTLLDDSKAAQHSHQQRMFSLANIGGLDTTISELKELLEMAFG 290

  Fly   270 IKSPEFYFQLGLLP-SRGLLLHGPPGCGKTFLARAISGQLKMPLMEIPATELIGGISGESEERI- 332
            :.|.    |..:.| |||:||.|..|.|||.|..|::......::.:..:|:.....||||..:
Mosquito   291 MDSK----QTTVGPVSRGILLSGVSGVGKTMLVNALATHYHCHVVRLNCSEVFSKFYGESEANVS 351

  Fly   333 ---REVFDQAIGYSPCVLFIDEIDAIGGNRQWASKDMERRIVSQLISSLDNLKANEFGQSVVVIA 394
               .||||  :...|.::.::|:..:....  .:.|:.:||....::.||:|.||..|...|||.
Mosquito   352 RQFAEVFD--VHPKPAMVVVEELHNLCPKS--TATDIVKRISQHFLTLLDSLHANVRGNRAVVIG 412

  Fly   395 ATTRPDVLDPGLRRIGRFDHEIAIHIPSRKERREILR--IQCEGLSVDPKLNYDKIAELTPGYVG 457
            .|...|.::|.|||.||.|:|..:.:|....|..||.  :...|.:| |:.:...:|.:|.||||
Mosquito   413 TTDSVDNVNPLLRRGGRMDYEFELPVPDAIARTAILERVLSRHGQTV-PEQDIRAVARITHGYVG 476

  Fly   458 ADLMALVSRAASVAVKRRSMKKFRELHAASEKNMTTVTLDDDEPSEDAGETPVPDSKGEETAKDA 522
            |||..|||:|||.|                                       |..|
Mosquito   477 ADLENLVSKAASSA---------------------------------------PTGK-------- 494

  Fly   523 EAEQKVDGDKETSAKDKSEGDSPNIETPKKATNGNSSIKSPQKTPKKSAEKPTDAAMDVDNVAPE 587
                .:||
Mosquito   495 ----PIDG--------------------------------------------------------- 498

  Fly   588 EPKKAVEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEFADPNFCLTLIDFVDAIKVMQPSAKREG 652
                                 |.|                          :.|::.::|||.||.
Mosquito   499 ---------------------PAL--------------------------MAALQHVKPSAMREI 516

  Fly   653 FITVPDTTWDDIGALEKIREELKLAVLAPVKYPEMLERLGLTAPSGVLLCGPPGCGKTLLAKAIA 717
            .|..|:..|.|||..::::.:|:..:..|:.:||:.:|||:..|.|:|:.|||||.||::|||||
Mosquito   517 MIECPNVRWTDIGGQDELKLKLRQIIDWPIHHPELFDRLGIKPPRGLLMFGPPGCSKTMIAKAIA 581

  Fly   718 NEAGINFISVKGPELMNMYVGESERAVRACFQRARNSAPCVIFFDEFDSLCPKRSDGGDGNNSGT 782
            .|:.:||:|:||.||.:|:|||||||||..|:|||..||.:|||||.|::..:|| ...|::...
Mosquito   582 TESRLNFLSIKGSELFSMWVGESERAVRDLFRRARQVAPSIIFFDEIDAIGGERS-AESGSSVKE 645

  Fly   783 RIVNQLLTEMDGVEERKGVYILAATNRPDIIDPAILRPGRLDTILYVGFPEQSERTEILKATTKN 847
            |::.|||||||||...|.|.|:|||||||:||.|::||||||.|:||..|:.:.|.||.:...|.
Mosquito   646 RVLAQLLTEMDGVSVLKDVRIVAATNRPDLIDRALMRPGRLDRIVYVRLPDAAAREEIFRIKLKT 710

  Fly   848 GKRPVLADDVDLDEIAAQTEGYTGADLAGLVKQASMFSLRQSLNNGDTNLDDLCVRSQHFQEALQ 912
              .|. |..|||.|:..:|.|.:|:::..:.::|::..|       :::.|...:..:||:.||.
Mosquito   711 --IPT-ASTVDLAELVRRTAGCSGSEIEAICQEAALKGL-------ESSFDVETIEWEHFEHALG 765

  Fly   913 QLRPSVNEQDRKIYDK 928
            .:||..:.:..::|::
Mosquito   766 VVRPRTSPELLRLYEE 781

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	199/654 (30%)
		AAA	287..418	CDD:278434	42/134 (31%)
		P-loop_NTPase	679..>716	CDD:304359	18/36 (50%)
		AAA	699..830	CDD:278434	77/130 (59%)
AgaP_AGAP012655	XP_001230510.1	SpoVK	302..772	CDD:223540	196/640 (31%)
		AAA	305..438	CDD:278434	42/136 (31%)
		AAA	563..694	CDD:278434	78/131 (60%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D169540at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820