DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and Fign

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_001099954.1	Gene:	Fign / 295649	RGDID:	1308174	Length:	759	Species:	Rattus norvegicus

Alignment Length:	481	Identity:	113/481 - (23%)
Similarity:	203/481 - (42%)	Gaps:	91/481 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   506 GETPV-PDSKGEETAKDAEAE---QKVDGDKETSAKDKSEGDSPNIETP---------KKATNGN 557
            |.||: |.:....:|...:.:   ....||.::|..:.|.|...:.::|         ..:..||
  Rat   299 GLTPIAPSALTNSSASSLKRKAFYMAGQGDMDSSYGNYSYGQQRSTQSPMYRMPDNSISNSNRGN 363

  Fly   558 SSIKSPQKTPKKSAEKPTDAAMDVDNVAPEEPKKAVEQEVD------------------SSSSND 604
            ...::.:.:  ..|.|||...|      |.|.::....:..                  ||.|..
  Rat   364 GFDRNAETS--SLAFKPTKQLM------PSEQQRKFSSQSSRALTPPSYSTAKNSLGSRSSESFG 420

  Fly   605 EYYEPTLAE--------LTNFLDNPPEEFAD----------PNFCLTLIDFVDAIKVMQPSAKRE 651
            :|..|.::|        |.:.:..|....|.          .|....|||.|....:.|.
  Rat   421 KYTSPVMSEHGDDHRQLLAHPIQGPGLRAATSSNHSVDEQLKNTDTHLIDLVTNEIITQG----- 480

  Fly   652 GFITVPDTTWDDIGALEKIREELKLAVLAPVKYPEMLERLGLTA-PSGVLLCGPPGCGKTLLAKA 715
                 |...|.||..|:.::..:|..||.||...:...  |||| |..:||.||.|.|||||.:.
  Rat   481 -----PPVDWSDIAGLDLVKAVIKEEVLWPVLRSDAFS--GLTALPRSILLFGPRGTGKTLLGRC 538

  Fly   716 IANEAGINFISVKGPELMNMYVGESERAVRACFQRARNSAPCVIFFDEFDSLCPKRSDGGDGNNS 780
            ||::.|..|..:.|..|:..::||:|:.:.|.|..||...|.|||..:.|.|.  .|...:.::.
  Rat   539 IASQLGATFFKIAGSGLVAKWLGEAEKIIHASFLVARCRQPSVIFVSDIDMLL--SSQVSEEHSP 601

  Fly   781 GTRIVNQLLTEMDGV----EERKGVYILAATNRPDIIDPAILRPGRLDTILYVGFPEQSERTEIL 841
            .:|:..:.|.::|.|    |::  :.::.||::|:.||.::.|  .....|.:..|:.:.|.:|:
  Rat   602 VSRMRTEFLMQLDTVLTSAEDQ--IVVICATSKPEEIDESLRR--YFMKRLLIPLPDSTARHQII 662

  Fly   842 KATTKNGKRPVLADDVDLDEIAAQTEGYTGADLAGLVKQASMFSLRQSLNNGDTNLDDLC----- 901
            ....  .:.....:|.:...:..:|||::|.|:|.|.::|::..|...   ..|:|..:.
  Rat   663 VQLL--SQHNYCLNDKEFALLVQRTEGFSGLDVAHLCQEAAVGPLHAM---PATDLSAIMPSQLR 722

  Fly   902 -VRSQHFQEALQQLRPSVNEQDRKIY 926
             :..|.|:.|..:::||:::::..:|
  Rat   723 PITYQDFENAFCKIQPSISQKELDMY 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	112/472 (24%)
		AAA	287..418	CDD:278434
		P-loop_NTPase	679..>716	CDD:304359	18/37 (49%)
		AAA	699..830	CDD:278434	42/134 (31%)
Fign	NP_001099954.1	AAA	519..654	CDD:214640	43/140 (31%)
		AAA	522..652	CDD:278434	42/135 (31%)
		Vps4_C	<723..756	CDD:286426	6/26 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900