DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment smid and ZK938.3

DIOPT Version :9

Sequence 1:	NP_523959.2	Gene:	smid / 38824	FlyBaseID:	FBgn0016983	Length:	944	Species:	Drosophila melanogaster
Sequence 2:	NP_001364588.1	Gene:	ZK938.3 / 191468	WormBaseID:	WBGene00014160	Length:	616	Species:	Caenorhabditis elegans

Alignment Length:	732	Identity:	135/732 - (18%)
Similarity:	251/732 - (34%)	Gaps:	248/732 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   272 SPEFYFQLGLLPSRGLLLHGPPGCGKTFLARAISGQLKMPLM--EIPATELIGGISGES-EERIR 333
            ||:||   |...::..|||         |...||.|||....  .:|.|.::..::|.: ::.|.
Worm    26 SPKFY---GTHQTKERLLH---------LVTLISSQLKQLNRGENVPRTRMVSNLAGNARKDLIF 78

  Fly   334 EVFDQAIGYSPCVLFIDEIDAIGGNRQWASKDMERRIVS-QLISS--LDNLK------------- 382
            |::...|.:...   .|.:.:|.|::    .:::..:|| :::||  ||...
Worm    79 EIYLNLISFYKT---SDRMVSIEGSQ----TNLKCLLVSAKMLSSFFLDVFTKIPTTHIESGFDE 136

  Fly   383 ---ANEFGQSVVVIAATTRPDVLDPGLRRIGRFDHEIAIHIPSRKE---RREILRIQCEG----- 436
               ::.|.|..|.|.:|.|  ::...  .||..:|.:.:....:::   |...|:.|.:.
Worm   137 FYISHSFTQEDVAITSTWR--MISQA--AIGHHEHHLEVKRACQEQKAFRESFLKTQTDFDIDFE 197

  Fly   437 ----------LSVD----------------PKLNY-----DKIAELTPGYVGADLMALVSRAASV 470
                      ||::                .:.||     ::.|||....|..|     :..|::
Worm   198 NAEAEQETQLLSIEYAVLIIQKLERKYQAISRRNYVRFVRERAAELHGLKVEID-----ATQAAI 257

  Fly   471 AVKRR-----SMKKFRELHAASEKNMTTVTLDDDEPSEDAGETPVPDSKGEETAKDAEAEQKVDG 530
            .::.|     :.|..||:.   ||.:..:.:             .|:|...:  :.||.|:|
Worm   258 RIQARTRGYFARKLVREMR---EKELNILNM-------------TPESYIRK--RCAERERK--- 301

  Fly   531 DKETSAKDKSEGDSPNI---ETPKKATNGNSSIKSPQKTPKKSAEKPTDAAMDVDNVAPEEPKKA 592
                    :.||.:..:   |..::....|:.:....|..|.....||.   |:.::.|
Worm   302 --------RKEGLAGGVGGGEIIEQIEEFNTDLAEALKLLKTHFFFPTS---DLTDIKP------ 349

  Fly   593 VEQEVDSSSSNDEYYEPTLAELTNFLDNPPEEFADPNFCLTLIDFVDAIKVMQPSAKRE------ 651
                               :.|...|:|....|.|..| ..::..:..|::.:.:::||
Worm   350 -------------------SALPIDLNNQETIFRDACF-RGIVSPLAQIELSELTSQREICKIEN 394

  Fly   652 --------GFITVPDTTWDDIGALEKIR-EELKLAVLAPVKYPEMLERLGLTAPSGVLLCGPPGC 707
                    .|:.....|...:|..:|.: ::.|:..|                    ||.|.|..
Worm   395 RQFKFDFRSFLVQTVCTPCSLGTWQKQKSKDQKMQWL--------------------LLSGAPDS 439

  Fly   708 GKTLLAKAIANEAGINFISVKGPELMNMYVGESERAVRACFQR-ARNSAPCVIFFDEFDSLCPKR 771
            |||..|:||:....:..:.: ...::||    .:|.:....:: |:.....::..|..|.:  |:
Worm   440 GKTTWARAISRACHVTHVHI-SKNVVNM----GKRKIYTVVKKLAKQEKRLLVSIDRIDVM--KK 497

  Fly   772 SDGGDGNNSGTRIVNQLLTEMDGVEERKGVYILAATNRPDIIDPAILRPGRLDTILYVGFPEQSE 836
            .....|......::...|:::..:   |.|.::..|..|  :|.       ||:.:...||
Worm   498 DPKHKGYTHRQILLRNFLSDLSNI---KFVMVIGMTRVP--LDD-------LDSYISDLFP---- 546

  Fly   837 RTEILKATTKNGKRPVLADDVDLD---------------------EIAAQTEGYTGADLAGLVKQ 880
                |:||..|   |..|...||.                     :|..||:..|..      |.
Worm   547 ----LQATLSN---PTNATRYDLAVDCLSRNWEQERLPKFPNRIFDIEKQTKDQTRG------KA 598

  Fly   881 ASMFSLRQSLNNGDTNL 897
            |...:.|.|..|..|.|
Worm   599 AKFVTNRWSAANNKTTL 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
smid	NP_523959.2	Nucleolin_bd	2..71	CDD:293330
		SpoVK	271..919	CDD:223540	135/732 (18%)
		AAA	287..418	CDD:278434	33/152 (22%)
		P-loop_NTPase	679..>716	CDD:304359	9/36 (25%)
		AAA	699..830	CDD:278434	26/131 (20%)
ZK938.3	NP_001364588.1	P-loop_NTPase	431..545	CDD:422963	27/152 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900