DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MED4 and Med4

DIOPT Version :9

Sequence 1:	NP_648094.1	Gene:	MED4 / 38799	FlyBaseID:	FBgn0035754	Length:	258	Species:	Drosophila melanogaster
Sequence 2:	NP_080395.1	Gene:	Med4 / 67381	MGIID:	1914631	Length:	270	Species:	Mus musculus

Alignment Length:	261	Identity:	113/261 - (43%)
Similarity:	166/261 - (63%)	Gaps:	30/261 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 STKERLLLLIDDIEMIAKELIE----QAHQKISSTELVD-LLDLLVAKDEEFRKMLELAEEQAKV 65
            ||:||||..::|:|::::||||    ..:||:...|..: :|:||:.:|.:|:::::||..|.||
Mouse    25 STRERLLSALEDLEVLSRELIEMLAISRNQKLLQLEEENQVLELLIHRDGDFQELMKLALNQGKV 89

  Fly    66 EEAMDQLRAKVEVHDREIQKLQKSLKDAELILSTAIFQARQKLASINQANKRPVSSEELIKYAHR 130
            ...|..|..:||..|.:||:|||.||:||.||:||::||::||.||.:|.|..:||||:||||||
Mouse    90 HHEMQALEKEVEKRDSDIQQLQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHR 154

  Fly   131 ISSANAVSAPLTWCIGDLRRPYPTDIEMRNGLLGKSEQNINGGTVTHQNSGMPSEQQRTLSGSAG 195
            ||::|||.|||||..||.|||||||:|||:||||:    :|..:.:..|..:|.:
Mouse   155 ISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQ----MNNPSTSGVNGHLPGD---------- 205

  Fly   196 SGSGSGAGGEVPNAFQNQFNWNLGELHMTMGASGNT--VALE-----TRAQDDVEVMSTDSSSSS 253
                :.|.|.:|:....|:.|...::.:.|....::  ..||     ...:||||||||||||||
Mouse   206 ----ALAAGRLPDVLAPQYPWQSNDMSVNMLPPNHSSDFLLEPPGHNKENEDDVEVMSTDSSSSS 266

  Fly   254 S 254
            |
Mouse   267 S 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MED4	NP_648094.1	Med4	47..189	CDD:287038	72/141 (51%)
Med4	NP_080395.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Med4	64..>202	CDD:287038	74/141 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	227..270		18/41 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832327
Domainoid	1	1.000	149	1.000	Domainoid score	I4422
eggNOG	1	0.900	-	-		E1_KOG4552
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8568
Inparanoid	1	1.050	190	1.000	Inparanoid score	I3879
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46272
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006646
OrthoInspector	1	1.000	-	-		oto93036
orthoMCL	1	0.900	-	-		OOG6_105627
Panther	1	1.100	-	-	LDO	PTHR13208
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2637
SonicParanoid	1	1.000	-	-		X4874
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790