DRSC/TRiP Functional Genomics Resources

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Protein Alignment: MED4 and MED4

Sequence 1:NP_648094.1 Gene:MED4 FlyBaseID:FBgn0035754 Length:258 Species:Drosophila melanogaster
Sequence 2:NP_054885.1 Gene:MED4 HGNCID:17903 Length:270 Species:Homo sapiens

Alignment Length:261 Identity:113/262 (43%)
Similarity:165/262 (63%) Gaps:30/262 (11%)


  Fly     6 STKERLLLLIDDIEMIAKELIE----QAHQK-ISSTELVDLLDLLVAKDEEFRKMLELAEEQAKV 65
            ||:||||..::|:|::::||||    ..:|| :.:.|...:|:||:.:|.||:::::||..|.|:
Human    25 STRERLLSALEDLEVLSRELIEMLAISRNQKLLQAGEENQVLELLIHRDGEFQELMKLALNQGKI 89

  Fly    66 EEAMDQLRAKVEVHDREIQKLQKSLKDAELILSTAIFQARQKLASINQANKRPVSSEELIKYAHR 130
            ...|..|..:||..|.:||:|||.||:||.||:||::||::||.||.:|.|..:||||:||||||
Human    90 HHEMQVLEKEVEKRDSDIQQLQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHR 154

  Fly   131 ISSANAVSAPLTWCIGDLRRPYPTDIEMRNGLLGKSEQNINGGTVTHQNSGMPSEQQRTLSGSAG 195
            ||::|||.|||||..||.|||||||:|||:||||:    :|..:....|..:|.:          
Human   155 ISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQ----MNNPSTNGVNGHLPGD---------- 205

  Fly   196 SGSGSGAGGEVPNAFQNQFNWNLGELHMTMGASGNT--VALE-----TRAQDDVEVMSTDSSSSS 253
                :.|.|.:|:....|:.|...::.|.|....::  ..||     ...:||||:|||||||||
Human   206 ----ALAAGRLPDVLAPQYPWQSNDMSMNMLPPNHSSDFLLEPPGHNKENEDDVEIMSTDSSSSS 266

  Fly   254 S 254
            |
Human   267 S 267

Known Domains:


GeneSequenceDomainRegion External IDIdentity
MED4NP_648094.1 Med4 47..189 CDD:287038 72/142 (51%)
MED4NP_054885.1 Med4 64..>202 CDD:287038 72/138 (52%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 C235038163
eggNOG 1 0.900 E1_KOG4552
Hieranoid 1 1.000
Homologene 1 1.000 H8568
Inparanoid 1 1.050 191 1.000 Inparanoid score I3821
Isobase 00.000 Not matched by this tool.
OMA 1 1.010
OrthoDB 1 1.010 D1333917at2759
OrthoFinder 1 1.000 FOG0005197
OrthoInspector 1 1.000 T1074751
orthoMCL 1 0.900 OOG5_132387
Panther 1 1.100 LDO PTHR13208
Phylome 1 0.910 0.667 Consistency score
RoundUp 1 1.030 avgDist Average_Evolutionary_Distance R2637
TreeFam 1 0.960
User_Submission 00.000 Not matched by this tool.
1413.800

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