DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Neos and ncoa5

DIOPT Version :9

Sequence 1:	NP_001261502.1	Gene:	Neos / 38795	FlyBaseID:	FBgn0024542	Length:	371	Species:	Drosophila melanogaster
Sequence 2:	XP_005166217.1	Gene:	ncoa5 / 447849	ZFINID:	ZDB-GENE-040912-155	Length:	622	Species:	Danio rerio

Alignment Length:	476	Identity:	99/476 - (20%)
Similarity:	181/476 - (38%)	Gaps:	161/476 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 TKDPALAKSRIFLGNLPVC--TREELVSICQPYGKVLGSMVQKNYGFVQFETEELANKAASALHK 74
            :.||...:.|||:||||..  .::::..:.:||||:....:.:.|||||||..|.|..|.:..:.
Zfish    19 SNDPRDLERRIFVGNLPTAHMAKKDMEDLFRPYGKIQALSLFRGYGFVQFERLEDAEAAKAGHNG 83

  Fly    75 STFKQNMLTVRNASIK--SKAANAIAKRNSNQGGQVTV-----------------QGGLVMSAAA 120
            ..::...|.|..|:.:  :|:.::..:|.|:..|:...                 :....|.|::
Zfish    84 RVYRGYKLDVNMAAERRQNKSRSSPPRRPSSSYGESREPRPRSRSPVHARDSRYHRESREMRASS 148

  Fly   121 -------------------------AAAGQPLIN------------------------------- 129
                                     :...:|.:.
Zfish   149 RESRPSSTREHEDRPPAEERYRGSESREKEPSLREEGYDRYYRGDYDYYRKKDEAYSDRYRDPWN 213

  Fly   130 --------------------------------------DCEIIVQNRENTKYAEYIEERLKNSSL 156
                                                  ||.:||.|:...:|||.:..::::..:
Zfish   214 GRREPEEERIRPEERRRNELYRQYYEELQKRYDIERPVDCSVIVVNKLQKEYAETVGRKVRDLGM 278

  Fly   157 RVDVLFPNEDVLLGKVLANISSRGCLYAVLVTPQHEEHNSITVNILYGVPAEHRNMPLEDAITLI 221
            .||::|.|.:|.|.:.|.::|.....:|:::|.||:.|.|.|||||:|.|.||||||::||:.|:
Zfish   279 VVDLIFLNTEVSLTQALEDVSRARTPFAIIITQQHQVHRSCTVNILFGTPQEHRNMPIQDAMVLV 343

  Fly   222 STDFRL------KKQRD-----AVVLPPSTSIHKGQRR-HPQEMQGLLERLADNHPLTASQYEVI 274
            :.:|..      .|:||     |..:.....:.:.:|. ||..:...:..|::...:|..:...:
Zfish   344 AHNFETFKVEHRAKERDEIARKAAKMADDVLMREHEREGHPVSVLTAITLLSEGRFMTPEELARL 408

  Fly   275 LKYLEGEREEQLK--REVGEANALAKLKAPDP--------------------------------E 305
            ::||..:|:..::  .:.|...:.|.|:...|                                :
Zfish   409 IEYLRDKRDRLVRSTTDAGPHPSSATLEPSQPTQAISAPAQPTYSSLSLQTSHLTPASAPAQTNQ 473

  Fly   306 IELQKKILSIMNKPAVTDVTS 326
            .|||.|||||.|..:.:.|.|
Zfish   474 QELQAKILSIFNSGSGSSVAS 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neos	NP_001261502.1	U2AF_lg	<19..149	CDD:273727	39/244 (16%)
Neos	NP_001261502.1	RRM_SF	20..78	CDD:388407	21/59 (36%)
ncoa5	XP_005166217.1	RRM	<1..168	CDD:223796	32/148 (22%)
ncoa5	XP_005166217.1	RRM_hnRNPC_like	27..94	CDD:240787	22/66 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592100
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I5029
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D421126at33208
OrthoFinder	1	1.000	-	-		FOG0006056
OrthoInspector	1	1.000	-	-		oto40048
orthoMCL	1	0.900	-	-		OOG6_109699
Panther	1	1.100	-	-	LDO	PTHR23295
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5288
SonicParanoid	1	1.000	-	-		X5759
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.930