DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dscam2 and PTPRQ

DIOPT Version :10

Sequence 1:NP_001261500.1 Gene:Dscam2 / 38788 FlyBaseID:FBgn0265296 Length:2101 Species:Drosophila melanogaster
Sequence 2:NP_001138498.1 Gene:PTPRQ / 374462 HGNCID:9679 Length:2299 Species:Homo sapiens


Alignment Length:1699 Identity:351/1699 - (20%)
Similarity:577/1699 - (33%) Gaps:539/1699 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   435 QPGPAVSLKCSAAGNPTPQISWTLDGFPLPSNGRFMIGQYI-----------TVHGDVISHVNIS 488
            :|||.|.|.....|:....:||..   |...|||.:  .||           ||:..|.|..:..
Human    55 KPGPPVFLAGERVGSAGILLSWNT---PPNPNGRII--SYIVKYKEVCPWMQTVYTQVRSKPDSL 114

  Fly   489 HVMVED---GGEY--ACIAENRAGRVQHAARLNIYGLPYIRLIPKVTAVSGETLNLKCPVAGYPI 548
            .|::.:   |..|  ...|||.||       :.::..|:  |.....:..|:.:||.........
Human   115 EVLLTNLNPGTTYEIKVAAENSAG-------IGVFSDPF--LFQTAESAPGKVVNLTVEAYNASA 170

  Fly   549 EEIHWERGGRELPDDIRQRVQPDGSLT-----------------------------ISPVQKNSD 584
            .::.|     .||.      ||:|.:|                             :....:||:
Human   171 VKLIW-----YLPR------QPNGKITSFKISVKHARSGIVVKDVSIRVEDILTGKLPECNENSE 224

  Fly   585 S------------GVYTCWARNKQGHSARRSGEVTVI-------VPPKLSPFQTNILQLNMGDRA 630
            |            |..|..:|.....|.....|::.:       |...|.|:.|.:.:::     
Human   225 SFLWSTASPSPTLGRVTPPSRTTHSSSTLTQNEISSVWKEPISFVVTHLRPYTTYLFEVS----- 284

  Fly   631 SLTCSVVKGDLPLTINWRKDGRPIDPTQHMSVKQVDQYNSILVIENLGSDHTGNYSCVVR---NS 692
              ..:...|.:..||....:..|..|.|:.....:.. .|..::.:..:..||.:|..|.   .|
Human   285 --AATTEAGYIDSTIVRTPESVPEGPPQNCVTGNITG-KSFSILWDPPTIVTGKFSYRVELYGPS 346

  Fly   693 AAEVENS----QALLVNVPP-----RWIVEPVDANVERNRHIMLHCQAQGVPTP----------- 737
            ...::||    :....|:.|     .:|.....|......:|       .|.||           
Human   347 GRILDNSTKDLKFAFTNLTPFTMYDVYIAAETSAGTGPKSNI-------SVFTPPDVPGAVFDLQ 404

  Fly   738 ---------SIVWKKATGSKSGEYEEVRERPF----------TKLLGNGSLL-------LQHVKE 776
                     .|.|||.. ..:|...:.|.:..          |.|.||...:       :.::.|
Human   405 LAEVESTQVRITWKKPR-QPNGIINQYRVKVLVPETGIILENTLLTGNNEYINDPMAPEIVNIVE 468

  Fly   777 DREGFYLCQANNGIGTGIGKVIQLKVNSSP--YFSSTSR-----SVMVKKGDTALLQCAVSGDKP 834
            ...|.|  :.:..:.:.:..:.....||.|  .|.:.:|     |.:|...:..:...|.   :.
Human   469 PMVGLY--EGSAEMSSDLHSLATFIYNSHPDKNFPARNRAEDQTSPVVTTRNQYITDIAA---EQ 528

  Fly   835 INIVWMRSGKNTLNPSTNYKISVKQ-EATPDGVSAELQIRTVDATDSGPYFCRASNLYGNDQQLV 898
            ::.|..|     |.|.|.:.|||.. ....:|....|.:||                        
Human   529 LSYVIRR-----LVPFTEHMISVSAFTIMGEGPPTVLSVRT------------------------ 564

  Fly   899 QLQVQEPPLPPSVLEAAMISSRSVNIKWQPKTLGTGDVTKYIVEFREADHSLPPALFVDQWQQIE 963
               .|:.|....::....|||.|:.:.|.|.....|.:|.|.:...|.|        .::..||.
Human   565 ---RQQVPSSIKIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELD--------TNRAFQIT 618

  Fly   964 VKDPPHFNAMIENLKPATRYAFRVIAEGSAGRSAPSQE--LIVRTEPQRPAGPPLSLSARPLSST 1026
            ..|.   :.:|..||..|:|..||.|....|.|:.|:|  :.|||....|...|..:....:::.
Human   619 TIDN---SFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTAD 680

  Fly  1027 ELLISWVAPLPELRHGDIQGYNVGYKLSSSGNTAYNFTSVSGDGDGGNGELLLSGLAKFARYTVV 1091
            |:.:.| :| ||..:|.|..|.|.||   :.:|.|...:.:.|       ::|..|.....|.:.
Human   681 EIRLKW-SP-PEKPNGIIIAYEVLYK---NIDTLYMKNTSTTD-------IILRNLRPHTLYNIS 733

  Fly  1092 VQAFNQVGPG-PLSEPTAAQTMEDVPSRPPEDVRCAALSSQSLQVSWQPPPIYHTNGLLQGYKLI 1155
            |:::.:.|.| .:|...:.:|.|.||...||::....:||..:::|:.||.  ..||::|.|.:.
Human   734 VRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPS--SPNGIIQKYTIY 796

  Fly  1156 FEPIIDDIQPSKDEVESRKTTALTMVLTGLRKYTNYSIQVLAHTRMGDGVVSKPLFCHSEEDVPE 1220
            .:      :.:.:|..:..||:||..:..|:|||.|.|:|.|.|..|:||.|.|:...:|||.|:
Human   797 LK------RSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPD 855

  Fly  1221 A-PADIKVVSSSSQSLYISWLPPNEPNGVITKYSLYTRVVNGREELNNEKRSLPSQQAYYEAKGL 1284
            : |.|..|...|..::.:||.||.||||:|..|::|....:..:.:|..:.||       |...|
Human   856 SPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETSL-------ELSDL 913

  Fly  1285 HPHMEYQFWVTASTRVGEGKSSRVSSQITTNRIPARIISFGGPVVRPWRSTVTLPCTAVGKPKRE 1349
            ..::||..:||||||.|:||:.            :.||||                         
Human   914 DYNVEYSAYVTASTRFGDGKTR------------SNIISF------------------------- 941

  Fly  1350 WFKSDVALRQGGLHNSQLLDSGDLIISSLQLADGGNYSCQVDNGIGTDRLTHTLIVQVPPTAPVL 1414
                                                   |...|..:|          ||..  :
Human   942 ---------------------------------------QTPEGAPSD----------PPKD--V 955

  Fly  1415 YVTSATSSSILMHWKCGFTGNAPITGYTLFYRRANGNTDEMQLSRHASSHELKGLMCG------- 1472
            |..:.:||||::.|......|..|..|:::||..:| |.....:.|..:::...:...       
Human   956 YYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSG-TFMQNFTLHEVTNDFDNMTVSTIIDKLT 1019

  Fly  1473 --STYQIHLSAQNKVGT-SPTSTILHVRTQGQSP-GHPASTALLAPNSTSLLVRLHSW----PDN 1529
              |.|...|:|...||. :.:|.|:.|.|....| |...:....:.:||::.|   ||    ..|
Human  1020 IFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINV---SWVPPAQPN 1081

  Fly  1530 GCPLLY--FVLQYRAVTDDPDAEWVLVSNALKP-----QRRIVINNLQPSTLYQLRMEAHNVAGI 1587
            |....|  .:||.             ....::|     :|.|..:||:..|.|.|::......|.
Human  1082 GLVFYYVSLILQQ-------------TPRHVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKGF 1133

  Fly  1588 SQAEFNFVTLTKDGDPPPPEIMHRGRSGQTTVIFANINLLIPTIAAVSGMFCTIIMIIVCYRHML 1652
            |......:.:..:.|.|           :|:          |.|.....:..|.:        :|
Human  1134 SDTYTAQLYIKTEEDVP-----------ETS----------PIINTFKNLSSTSV--------LL 1169

  Fly  1653 KNAPPLAEQSQIQKESLENRANSEAAQRERYYATIHKVSMQNNDKIPETS------EDISPYATF 1711
            ...||:.....|....|..:..:|      .|:.|             ||      |::||:..:
Human  1170 SWDPPVKPNGAIISYDLTLQGPNE------NYSFI-------------TSDNYIILEELSPFTLY 1215

  Fly  1712 QLSEAGGNMSQPHHG-GPANTLLHSFMYHERA--LAE-------GCS--------SPPPAASKNR 1758
            ....|    ::...| ||::.|   |.|.:.:  ||.       .|:        ||.|......
Human  1216 SFFAA----ARTRKGLGPSSIL---FFYTDESVPLAPPQNLTLINCTSDFVWLKWSPSPLPGGIV 1273

  Fly  1759 RRHSRKTEPESEESESDQDQLTSSRTESSNQHEGKIKHSIIYHGAQSSTSSD-----LSPMSEQK 1818
            :.:|.|.    .|.|:|                      .||:...|...::     |.|:|   
Human  1274 KVYSFKI----HEHETD----------------------TIYYKNISGFKTEAKLVGLEPVS--- 1309

  Fly  1819 SLPRRGRSRYHHQQYQFSTNTTPRHHNSNKMNN-----------NTTSNTNTTATN--------- 1863
                         .|....:...:..|.|:.:|           :...|....||:         
Human  1310 -------------TYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWD 1361

  Fly  1864 ---------TTATPSTSSNSNKILSPRGGN------LKSISSTFKSQ--------DSIQCHIPTL 1905
                     |....:...||.|: ||:...      |.:.|..||.:        |...||:.||
Human  1362 PPKKANGIITQYMVTVERNSTKV-SPQDHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTL 1425

  Fly  1906 VKS-PSIST 1913
            .:: ||:.|
Human  1426 PETVPSVPT 1434

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dscam2NP_001261500.1 Ig 30..128 CDD:472250
Ig strand B 49..53 CDD:409353
Ig strand C 62..66 CDD:409353
Ig strand E 86..90 CDD:409353
Ig strand F 106..111 CDD:409353
Ig strand G 119..123 CDD:409353
V-set 138..229 CDD:462230
Ig 238..327 CDD:472250
Ig strand B 255..259 CDD:409353
Ig strand C 268..272 CDD:409353
Ig strand E 293..297 CDD:409353
Ig strand F 307..312 CDD:409353
Ig strand G 320..323 CDD:409353
Ig 330..418 CDD:472250
Ig strand B 348..352 CDD:409353
Ig strand C 365..369 CDD:409353
Ig strand E 383..387 CDD:409353
Ig strand F 397..402 CDD:409353
Ig strand G 411..414 CDD:409353
IgI_4_Dscam 422..517 CDD:409548 26/97 (27%)
Ig strand A 422..425 CDD:409548
Ig strand A' 431..435 CDD:409548 351/1699 (21%)
Ig strand B 438..447 CDD:409548 3/8 (38%)
Ig strand C 452..458 CDD:409548 2/5 (40%)
Ig strand C' 460..463 CDD:409548 0/2 (0%)
Ig strand D 468..476 CDD:409548 3/18 (17%)
Ig strand E 480..489 CDD:409548 2/8 (25%)
Ig strand F 496..504 CDD:409548 2/9 (22%)
Ig strand G 507..517 CDD:409548 1/9 (11%)
IgI_5_Dscam 521..608 CDD:409550 20/127 (16%)
Ig strand A 521..523 CDD:409550 1/1 (100%)
Ig strand A' 528..532 CDD:409550 0/3 (0%)
Ig strand B 535..542 CDD:409550 2/6 (33%)
Ig strand C 549..555 CDD:409550 1/5 (20%)
Ig strand C' 556..558 CDD:409550 0/1 (0%)
Ig strand D 565..569 CDD:409550 0/3 (0%)
Ig strand E 572..578 CDD:409550 2/34 (6%)
Ig strand F 586..594 CDD:409550 2/7 (29%)
Ig strand G 598..608 CDD:409550 2/9 (22%)
Ig 611..704 CDD:472250 17/99 (17%)
Ig strand B 630..634 CDD:409353 0/3 (0%)
Ig strand C 644..648 CDD:409353 2/3 (67%)
Ig strand E 670..674 CDD:409353 1/3 (33%)
Ig strand F 684..689 CDD:409353 1/4 (25%)
Ig strand G 697..700 CDD:409353 2/6 (33%)
IgI_7_Dscam 707..802 CDD:409546 20/136 (15%)
Ig strand A 707..711 CDD:409546 1/8 (13%)
Ig strand A' 716..720 CDD:409546 1/3 (33%)
Ig strand B 723..732 CDD:409546 1/8 (13%)
Ig strand C 738..744 CDD:409546 3/5 (60%)
Ig strand C' 750..753 CDD:409546 1/2 (50%)
Ig strand D 761..764 CDD:409546 1/2 (50%)
Ig strand E 767..773 CDD:409546 0/12 (0%)
Ig strand F 780..788 CDD:409546 2/7 (29%)
Ig strand G 793..802 CDD:409546 0/8 (0%)
Ig 806..892 CDD:472250 18/93 (19%)
Ig strand B 823..827 CDD:409353 0/3 (0%)
Ig strand C 836..840 CDD:409353 1/3 (33%)
Ig strand E 868..872 CDD:409353 1/3 (33%)
Ig strand F 882..887 CDD:409353 0/4 (0%)
FN3 <904..1195 CDD:442628 79/293 (27%)
FN3 906..1006 CDD:238020 28/101 (28%)
fn3 1221..1306 CDD:394996 31/85 (36%)
Ig 1336..1396 CDD:409353 2/59 (3%)
Ig strand B 1336..1340 CDD:409353 0/3 (0%)
Ig strand E 1371..1375 CDD:409353 0/3 (0%)
Ig strand F 1385..1390 CDD:409353 0/4 (0%)
FN3 <1407..>1606 CDD:442628 50/220 (23%)
fn3 1408..1491 CDD:394996 22/92 (24%)
PTPRQNP_001138498.1 FN3 <14..303 CDD:442628 53/279 (19%)
FN3 56..150 CDD:238020 28/107 (26%)
FN3 307..392 CDD:238020 16/92 (17%)
FN3 397..>434 CDD:238020 6/37 (16%)
FN3 569..653 CDD:238020 26/94 (28%)
FN3 687..1202 CDD:442628 159/693 (23%)
FN3 1010..1573 CDD:442628 100/539 (19%)
fn3 1540..1618 CDD:394996
FN3 1643..1732 CDD:238020
UP_III_II 1748..1926 CDD:471435
R-PTPc-Q 2031..2254 CDD:350464
Blue background indicates that the domain is not in the aligned region.

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