DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dscam2 and zig-4

DIOPT Version :9

Sequence 1:	NP_001261500.1	Gene:	Dscam2 / 38788	FlyBaseID:	FBgn0265296	Length:	2101	Species:	Drosophila melanogaster
Sequence 2:	NP_509335.1	Gene:	zig-4 / 181051	WormBaseID:	WBGene00006981	Length:	253	Species:	Caenorhabditis elegans

Alignment Length:	225	Identity:	52/225 - (23%)
Similarity:	86/225 - (38%)	Gaps:	68/225 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   324 RLTVATPIQVEISPNVLSVHMGGTAEFRCLVTS----------NGSPVGMQNILWYKD-----GR 373
            ::.:..|::..:.|.      |.|.:.||.:.|          ||..:...|.|..::     |:
Worm    45 KIKIVAPLESALIPG------GETYQLRCDIMSTPAATIHWKFNGKLIQGSNELNVEEKLLNFGK 103

  Fly   374 QLPSSGRVEDTLVVPRVSRENRGMYQCVVRRPEGDTFQATAELQL-GD----------APPVLLY 427
            .:..:|.|...|.:...|.||.|.|.||..... .|.:..||::: |:          ||.::.:
Worm   104 AIVDTGIVASILTIQCPSAENSGTYSCVGYNGH-QTIETVAEVEIEGEASGCRSNHKSAPEIVFW 167

  Fly   428 --SFIEQTLQPGPAVSLKCSAAGNPTPQISWTL----------DGFPLPSNGRFMIGQYITVHGD 480
              |..|.|   |...:|.|.|    ..|:.|..          |.|.:.||            ||
Worm   168 TDSRFEMT---GNVATLVCRA----NQQVDWVWMSNDELVKNNDKFTVLSN------------GD 213

  Fly   481 VISHVNISHVMVEDGGEYACIAENRAGRVQ 510
            ::    |.:::.:|.|.|.|||.|:.|..:
Worm   214 LV----IKNIVWDDMGTYTCIARNQFGEAR 239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dscam2	NP_001261500.1	Ig	51..127	CDD:299845
		Ig	138..>203	CDD:299845
		I-set	238..327	CDD:254352	0/2 (0%)
		Ig	247..327	CDD:299845	0/2 (0%)
		I-set	332..418	CDD:254352	24/100 (24%)
		IGc2	344..407	CDD:197706	20/77 (26%)
		IG_like	432..517	CDD:214653	22/89 (25%)
		IGc2	436..507	CDD:197706	20/80 (25%)
		I-set	521..610	CDD:254352
		IGc2	533..597	CDD:197706
		Ig	630..699	CDD:143165
		IG_like	714..802	CDD:214653
		Ig	725..802	CDD:299845
		Ig	823..894	CDD:143165
		FN3	906..1006	CDD:238020
		FN3	1013..1111	CDD:238020
		FN3	1119..1209	CDD:238020
		FN3	1219..1313	CDD:238020
		Ig	1336..1402	CDD:143165
		FN3	1409..1498	CDD:238020
		FN3	1515..1588	CDD:238020
zig-4	NP_509335.1	I-set	47..147	CDD:254352	25/106 (24%)
		Ig	65..144	CDD:143165	19/79 (24%)
		IG_like	176..245	CDD:214653	21/84 (25%)
		Ig	<193..238	CDD:299845	15/60 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810