Protein Alignment Galphai and GNAQ

DIOPT Version :10

• Sequence 1: NP_477502.1
• Gene: Galphai / 38765
• FlyBaseID: FBgn0001104
• Length: 355
• Species: Drosophila melanogaster
• Sequence 2: NP_002063.2
• Gene: GNAQ / 2776
• HGNCID: 4390
• Length: 359
• Species: Homo sapiens
• Alignment Length: 358
• Identity: 179/358 - (50%)
• Similarity: 228/358 - (63%)
• Gaps: 10/358 - (2%)

  Fly     1 MGCAVSTARDKEAIERSKNIDRALRAEGERAASEVKLLLLGAGESGKSTIVKQMKIIHDTGYSQE 65
            |.|.:| ...|||...:..|:|.||.:...|..|:||||||.|||||||.:|||:|||.:|||.|
Human     7 MACCLS-EEAKEARRINDEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDE 70

  Fly    66 ECEEYRRVVFSNTVQSLMVIIRAMGRLKIEFA---DPSRTDIARQFFTHASAADEGILLPEIVLL 127
            :...:.::|:.|...::..:||||..|||.:.   :.:...:.|:......:|.|...:..|
Human    71 DKRGFTKLVYQNIFTAMQAMIRAMDTLKIPYKYEHNKAHAQLVREVDVEKVSAFENPYVDAI--- 132

  Fly   128 MKKLWADGGVQQSFARSREYQLNDSAGYYLNSLDRIAQPNYIPTQQDVLRTRVKTTGIIETHFSC 192
             |.||.|.|:|:.:.|.|||||:||..||||.|||:|.|.|:||||||||.||.||||||..|..
Human   133 -KSLWNDPGIQECYDRRREYQLSDSTKYYLNDLDRVADPAYLPTQQDVLRVRVPTTGIIEYPFDL 196

  Fly   193 KQLHFKLFDVGGQRSERKKWIHCFEGVTAIIFCVALSGYDLVLAEDEEMNRMIESLKLFDSICNS 257
            :.:.|::.|||||||||:|||||||.||:|:|.||||.||.||.|.:..|||.||..||.:|...
Human   197 QSVIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITY 261

  Fly   258 KWFVETSIILFLNKKDLFEEKIKRSPLTICFPEYTGTNTFEEAA-NYIRMKFENLNKRKDQKEIY 321
            .||..:|:|||||||||.||||..|.|...||||.|.....:|| .:|...|.:||...| |.||
Human   262 PWFQNSSVILFLNKKDLLEEKIMYSHLVDYFPEYDGPQRDAQAAREFILKMFVDLNPDSD-KIIY 325

  Fly   322 THLTCATDTNNVKFVFDAVTDVIIKNNLKQIGL 354
            :|.||||||.|::|||.||.|.|::.|||:..|
Human   326 SHFTCATDTENIRFVFAAVKDTILQLNLKEYNL 358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphai	NP_477502.1	G-alpha	35..349	CDD:206639	163/317 (51%)
GNAQ	NP_002063.2	G-alpha	40..353	CDD:206639	163/317 (51%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	41..54		11/12 (92%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	178..186		6/7 (86%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	201..210		5/8 (63%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	270..277		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	329..334		4/4 (100%)