Protein Alignment Galphai and GNAL

DIOPT Version :10

• Sequence 1: NP_477502.1
• Gene: Galphai / 38765
• FlyBaseID: FBgn0001104
• Length: 355
• Species: Drosophila melanogaster
• Sequence 2: NP_892023.1
• Gene: GNAL / 2774
• HGNCID: 4388
• Length: 458
• Species: Homo sapiens
• Alignment Length: 385
• Identity: 153/385 - (39%)
• Similarity: 216/385 - (56%)
• Gaps: 54/385 - (14%)

  Fly     8 ARDKEAIER----SKNIDRALRAEGERAASEVKLLLLGAGESGKSTIVKQMKIIHDTGYSQEECE 68
            |:::||::.    |:.|||.||.:........:||||||||||||||||||:|:|..|::.||.:
Human    89 AKEREAVKEARKVSRGIDRMLRDQKRDLQQTHRLLLLGAGESGKSTIVKQMRILHVNGFNPEEKK 153

  Fly    69 EYRRVVFSNTVQSLMVIIRAMGRL--KIEFADPS---RTD------------IARQFFTHASAAD 116
            :....:..|...:::.|:.||..:  .:..|:|.   |:|            .:::||.|
Human   154 QKILDIRKNVKDAIVTIVSAMSTIIPPVPLANPENQFRSDYIKSIAPITDFEYSQEFFDH----- 213

  Fly   117 EGILLPEIVLLMKKLWADGGVQQSFARSREYQLNDSAGYYLNSLDRIAQPNYIPTQQDVLRTRVK 181
                       :||||.|.||:..|.||.||||.|.|.|:|..:|.::..:|.||.||:||.||.
Human   214 -----------VKKLWDDEGVKACFERSNEYQLIDCAQYFLERIDSVSLVDYTPTDQDLLRCRVL 267

  Fly   182 TTGIIETHFSCKQLHFKLFDVGGQRSERKKWIHCFEGVTAIIFCVALSGYDLVLAEDEEMNRMIE 246
            |:||.||.|...:::|.:|||||||.||:|||.||..|||||:..|.|.|::|:.||...||:.|
Human   268 TSGIFETRFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIYVAACSSYNMVIREDNNTNRLRE 332

  Fly   247 SLKLFDSICNSKWFVETSIILFLNKKDLFEEKI--KRSPLTICFPEYTGTNTFEEAAN------- 302
            ||.||:||.|::|....||||||||:|:..||:  .:|.:...||||......|:|..
Human   333 SLDLFESIWNNRWLRTISIILFLNKQDMLAEKVLAGKSKIEDYFPEYANYTVPEDATPDAGEDPK 397

  Fly   303 ------YIRMKFENLNKRK-DQKE-IYTHLTCATDTNNVKFVFDAVTDVIIKNNLKQIGL 354
                  :||..|..::... |.|. .|.|.|||.||.|::.||:...|:|.:.:|||..|
Human   398 VTRAKFFIRDLFLRISTATGDGKHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLKQYEL 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphai	NP_477502.1	G-alpha	35..349	CDD:206639	140/347 (40%)
GNAL	NP_892023.1	G-alpha	120..452	CDD:206639	140/347 (40%)