DRSC/TRiP Functional Genomics Resources

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Protein Alignment Galphai and GNAI1

DIOPT Version :10

Sequence 1:NP_477502.1 Gene:Galphai / 38765 FlyBaseID:FBgn0001104 Length:355 Species:Drosophila melanogaster
Sequence 2:NP_002060.4 Gene:GNAI1 / 2770 HGNCID:4384 Length:354 Species:Homo sapiens


Alignment Length:355 Identity:276/355 - (77%)
Similarity:311/355 - (87%) Gaps:1/355 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGCAVSTARDKEAIERSKNIDRALRAEGERAASEVKLLLLGAGESGKSTIVKQMKIIHDTGYSQE 65
            |||.:| |.||.|:||||.|||.||.:||:||.|||||||||||||||||||||||||:.|||:|
Human     1 MGCTLS-AEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGYSEE 64

  Fly    66 ECEEYRRVVFSNTVQSLMVIIRAMGRLKIEFADPSRTDIARQFFTHASAADEGILLPEIVLLMKK 130
            ||::|:.||:|||:||::.||||||||||:|.|.:|.|.|||.|..|.||:||.:..|:..::|:
Human    65 ECKQYKAVVYSNTIQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMTAELAGVIKR 129

  Fly   131 LWADGGVQQSFARSREYQLNDSAGYYLNSLDRIAQPNYIPTQQDVLRTRVKTTGIIETHFSCKQL 195
            ||.|.|||..|.|||||||||||.||||.||||||||||||||||||||||||||:||||:.|.|
Human   130 LWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRTRVKTTGIVETHFTFKDL 194

  Fly   196 HFKLFDVGGQRSERKKWIHCFEGVTAIIFCVALSGYDLVLAEDEEMNRMIESLKLFDSICNSKWF 260
            |||:||||||||||||||||||||||||||||||.||||||||||||||.||:||||||||:|||
Human   195 HFKMFDVGGQRSERKKWIHCFEGVTAIIFCVALSDYDLVLAEDEEMNRMHESMKLFDSICNNKWF 259

  Fly   261 VETSIILFLNKKDLFEEKIKRSPLTICFPEYTGTNTFEEAANYIRMKFENLNKRKDQKEIYTHLT 325
            .:||||||||||||||||||:||||||:|||.|:||:||||.||:.:||:||||||.||||||.|
Human   260 TDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHFT 324

  Fly   326 CATDTNNVKFVFDAVTDVIIKNNLKQIGLF 355
            |||||.||:||||||||||||||||..|||
Human   325 CATDTKNVQFVFDAVTDVIIKNNLKDCGLF 354

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GalphaiNP_477502.1 G-alpha 35..349 CDD:206639 248/313 (79%)
GNAI1NP_002060.4 G-alpha 34..348 CDD:206639 248/313 (79%)
G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230 35..48 12/12 (100%)
G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230 173..181 7/7 (100%)
G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230 196..205 7/8 (88%)
G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230 265..272 6/6 (100%)
G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230 324..329 4/4 (100%)

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