Protein Alignment Galphai and Gnas

DIOPT Version :10

• Sequence 1: NP_477502.1
• Gene: Galphai / 38765
• FlyBaseID: FBgn0001104
• Length: 355
• Species: Drosophila melanogaster
• Sequence 2: NP_034439.2
• Gene: Gnas / 14683
• MGIID: 95777
• Length: 1133
• Species: Mus musculus
• Alignment Length: 403
• Identity: 158/403 - (39%)
• Similarity: 215/403 - (53%)
• Gaps: 75/403 - (18%)

  Fly    11 KEAIE----------RSKNIDRALRAEGERAASEVKLLLLGAGESGKSTIVKQMKIIHDTGYSQE 65
            |||||          |||.||:.|..|........:||||||||||||||||||:|:|..|::.|
Mouse   746 KEAIEMREQKRADKKRSKLIDKQLEEEKMDYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNGE 810

  Fly    66 ECEEYRRVVFSNT---------------VQSLMVIIRAMGRL--KIEFADPSRT----------- 102
            ..||..:...||:               .:::..|:.||..|  .:|.|:|...
Mouse   811 GGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMN 875

  Fly   103 ----DIARQFFTHASAADEGILLPEIVLLMKKLWADGGVQQSFARSREYQLNDSAGYYLNSLDRI 163
                |...:|:.||                |.||.|.||:..:.||.||||.|.|.|:|:.:|.|
Mouse   876 VPNFDFPPEFYEHA----------------KALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVI 924

  Fly   164 AQPNYIPTQQDVLRTRVKTTGIIETHFSCKQLHFKLFDVGGQRSERKKWIHCFEGVTAIIFCVAL 228
            .|.:|:|:.||:||.||.|:||.||.|...:::|.:|||||||.||:|||.||..||||||.||.
Mouse   925 KQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVAS 989

  Fly   229 SGYDLVLAEDEEMNRMIESLKLFDSICNSKWFVETSIILFLNKKDLFEEKI--KRSPLTICFPEY 291
            |.|::|:.||.:.||:.|:|.||.||.|::|....|:||||||:||..||:  .:|.:...|||:
Mouse   990 SSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEF 1054

  Fly   292 TGTNTFEEA------------ANY-IRMKFENLNKRK--DQKEIYTHLTCATDTNNVKFVFDAVT 341
            ....|.|:|            |.| ||.:|..::...  .:...|.|.|||.||.|::.||:...
Mouse  1055 ARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCR 1119

  Fly   342 DVIIKNNLKQIGL 354
            |:|.:.:|:|..|
Mouse  1120 DIIQRMHLRQYEL 1132

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphai	NP_477502.1	G-alpha	35..349	CDD:206639	143/362 (40%)
Gnas	NP_034439.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..195
		PHA03247	<50..496	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	322..552
		PRK12323	<330..531	CDD:481241
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	611..648
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	724..744
		UDM1_RNF168_RNF169-like	730..>772	CDD:409016	11/25 (44%)
		G-alpha	780..1127	CDD:206639	143/362 (40%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	781..794		11/12 (92%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	807..828		5/20 (25%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	935..943		5/7 (71%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	958..967		6/8 (75%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	1027..1034		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	1103..1108		3/4 (75%)