Protein Alignment Galphai and Gna12

DIOPT Version :10

• Sequence 1: NP_477502.1
• Gene: Galphai / 38765
• FlyBaseID: FBgn0001104
• Length: 355
• Species: Drosophila melanogaster
• Sequence 2: NP_034432.1
• Gene: Gna12 / 14673
• MGIID: 95767
• Length: 379
• Species: Mus musculus
• Alignment Length: 366
• Identity: 148/366 - (40%)
• Similarity: 213/366 - (58%)
• Gaps: 33/366 - (9%)

  Fly     8 ARD--KEAIERSKNIDRALRAEGERAASEVKLLLLGAGESGKSTIVKQMKIIHDTGYSQEECEEY 70
            |||  :||..||::||..|..|.......||:||||||||||||.:|||:|||...:.|:...|:
Mouse    27 ARDAEREARRRSRDIDALLARERRAVRRLVKILLLGAGESGKSTFLKQMRIIHGREFDQKALLEF 91

  Fly    71 RRVVFSNTVQSLMVIIRAMGRLKIEFADPSRTDIARQFFTHASAADEGILLPEI----------- 124
            |..:|.|.::...|::.|..:|.|.             :.|:.....|:.|...
Mouse    92 RDTIFDNILKGSRVLVDARDKLGIP-------------WQHSENEKHGMFLMAFENKAGLPVEPA 143

  Fly   125 -----VLLMKKLWADGGVQQSFARSREYQLNDSAGYYLNSLDRIAQPNYIPTQQDVLRTRVKTTG 184
                 |..:..||.|.|::::|:|..|:||.:|..|:|::||||.|.||.|::||:|..|..|.|
Mouse   144 TFQLYVPALSALWRDSGIREAFSRRSEFQLGESVKYFLDNLDRIGQLNYFPSKQDILLARKATKG 208

  Fly   185 IIETHFSCKQLHFKLFDVGGQRSERKKWIHCFEGVTAIIFCVALSGYDLVLAEDEEMNRMIESLK 249
            |:|..|..|::.||:.|||||||:|:||..||:|:|:|:|.|:.|.||.||.||...||::||:.
Mouse   209 IVEHDFVIKKIPFKMVDVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMN 273

  Fly   250 LFDSICNSKWFVETSIILFLNKKDLFEEKIKRSPLTICFPEYTG-TNTFEEAANYIRMKFENLNK 313
            :|::|.|:|.|...||||||||.||..||:|...:...||::.| .:..|:...|:...|:. .:
Mouse   274 IFETIVNNKLFFNVSIILFLNKMDLLVEKVKSVSIKKHFPDFKGDPHRLEDVQRYLVQCFDR-KR 337

  Fly   314 RKDQKEIYTHLTCATDTNNVKFVFDAVTDVIIKNNLKQIGL 354
            |...|.::.|.|.|.||.|::|||.||.|.|::.|||.|.|
Mouse   338 RNRSKPLFHHFTTAIDTENIRFVFHAVKDTILQENLKDIML 378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Galphai	NP_477502.1	G-alpha	35..349	CDD:206639	132/330 (40%)
Gna12	NP_034432.1	G_alpha	40..377	CDD:214595	139/350 (40%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	57..70		11/12 (92%)
		G2 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	198..206		3/7 (43%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	221..230		6/8 (75%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	290..297		6/6 (100%)
		G5 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01230	349..354		2/4 (50%)