DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4E4 and eif4eb

DIOPT Version :9

Sequence 1:	NP_648052.1	Gene:	eIF4E4 / 38743	FlyBaseID:	FBgn0035709	Length:	229	Species:	Drosophila melanogaster
Sequence 2:	NP_001007778.1	Gene:	eif4eb / 493617	ZFINID:	ZDB-GENE-041121-14	Length:	216	Species:	Danio rerio

Alignment Length:	231	Identity:	101/231 - (43%)
Similarity:	142/231 - (61%)	Gaps:	18/231 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LTTQQTEFKMMDNGTETLADSPSSSSEDLKTLSDMDIRKPVTEIVDLRLKHPLENTWTLWYLEND 66
            :.|.:.|.|          .:...|.|::...|:.:|..|.:.|     ||||:|.|.||:.:||
Zfish     1 MATAEPEIK----------SNSCKSEEEISDESNQEIVSPESYI-----KHPLQNRWCLWFFKND 50

  Fly    67 RSKNWEDMQNEITSFDMVEDFWSLYNHIKQPSEIRVGSDYSLFKKGIQPMWEDDANKFGGRWVIN 131
            :||.|:.....|:.||.|||||:|||||:..|.:..|.||||||.||:|||||:.||.||||:|.
Zfish    51 KSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMSGCDYSLFKDGIEPMWEDERNKRGGRWLIT 115

  Fly   132 MGRGS-KAELDKLWLDVLLILIGEAFEN-TEEVCGAVINLRGKSNKISIWTANGHNELAVMEIGL 194
            :.:.. |.:||:.||:.||.||||||:: :::|||||:|:|.|.:||:||||:..|..||..||.
Zfish   116 LNKQQRKYDLDRFWLETLLCLIGEAFDDYSDDVCGAVVNVRTKGDKIAIWTADYGNREAVTHIGR 180

  Fly   195 KLRDLLVLPPHQ-LQYQLHKDTMCKQGSVIKAVYCV 229
            ..::.|.:|.:. :.||.|.||..|.||..|..:.|
Zfish   181 VYKERLGVPMNMTIGYQSHADTATKSGSTTKNKFVV 216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4E4	NP_648052.1	IF4E	56..209	CDD:279921	78/155 (50%)
eif4eb	NP_001007778.1	IF4E	40..196	CDD:279921	78/155 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573563
Domainoid	1	1.000	193	1.000	Domainoid score	I3137
eggNOG	1	0.900	-	-		E1_COG5053
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H123817
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3585
OMA	1	1.010	-	-		QHG54586
OrthoDB	1	1.010	-	-		D1394271at2759
OrthoFinder	1	1.000	-	-		FOG0000666
OrthoInspector	1	1.000	-	-		mtm6577
orthoMCL	1	0.900	-	-		OOG6_100627
Panther	1	1.100	-	-	O	PTHR11960
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R595
SonicParanoid	1	1.000	-	-		X406
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800