DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment axed and Btbd6

DIOPT Version :9

Sequence 1:	NP_001356975.1	Gene:	axed / 38741	FlyBaseID:	FBgn0035708	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_964008.2	Gene:	Btbd6 / 399566	MGIID:	3026623	Length:	539	Species:	Mus musculus

Alignment Length:	340	Identity:	79/340 - (23%)
Similarity:	124/340 - (36%)	Gaps:	87/340 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 APAPSAP-PAHMMPPAYARGQTNIYTGVPIIVNPYIDFIVVNGDDRYMIRCERKSVLERSVELAK 185
            ||||..| ||   ||            :|...||...    |....:....||.:::..: ||..
Mouse    93 APAPLPPLPA---PP------------LPDNNNPESP----NWQSFHPTLRERNALMFNN-ELMA 137

  Fly   186 LIH---AGPNSGRKSDNHFQILNVDKNDFELIVRYMEKHFIPYRDHKHLLKILELSDRFNVPDLI 247
            .:|   ....:.|:...|..:|.|..:.|         :.:.|.|      :.|:....::||
Mouse   138 DVHFIVGALGAARRVPAHKYVLAVGSSVF---------YAMFYGD------LAEVKSEIHIPD-- 185

  Fly   248 IYCIRELDLRISSATALDIFKALWFYQGIALTNQHQTVITTQETGQQLARKKATKAKAAAKQL-- 310
                      :..|..|.:.|.::..:   :..:..||:.|              ..||.|.:
Mouse   186 ----------VEPAAFLVLLKYMYSDE---IDLEADTVLAT--------------LYAAKKYIVP 223

  Fly   311 AAAKASQS-TENGAEGDGA-----QQNLIPNPNPFTTEDYGVALLHNTLQLIDMHAELQLSMPEI 369
            |.|||..: .|...|...|     |..|...|.          |.....::||..||:.|.....
Mouse   224 ALAKACVNFLETSLEAKNACVLLSQSRLFEEPE----------LTQRCWEVIDAQAEMALRSEGF 278

  Fly   370 SDLRFEELETLVKRDTLQLRSEVTLFECLATWSLAECARKHIDATPENRRTVLGPLCLTPRYLRM 434
            .::..:.||.:|.|:.|..: |..:||.:..|:.|||.|:.:..||.|:|.|||......|...|
Mouse   279 CEIDRQTLEIIVTREALNTK-EAVVFEAVLNWAEAECKRQGLPVTPHNKRHVLGRALYLVRIPTM 342

  Fly   435 TASEFRRCCERLELL 449
            |..||.....:.::|
Mouse   343 TLEEFANGAAQSDIL 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
axed	NP_001356975.1	BTB	<192..258	CDD:197585	10/65 (15%)
axed	NP_001356975.1	BACK	<354..423	CDD:355779	23/68 (34%)
Btbd6	NP_964008.2	BTB	130..233	CDD:279045	26/147 (18%)
		BTB	138..237	CDD:197585	25/142 (18%)
		BACK	243..349	CDD:197943	34/116 (29%)
		PHR	394..537	CDD:285277
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2075
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45774
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910