DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment axed and BTBD19

DIOPT Version :9

Sequence 1:	NP_001356975.1	Gene:	axed / 38741	FlyBaseID:	FBgn0035708	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	XP_016855936.1	Gene:	BTBD19 / 149478	HGNCID:	27145	Length:	481	Species:	Homo sapiens

Alignment Length:	300	Identity:	54/300 - (18%)
Similarity:	88/300 - (29%)	Gaps:	108/300 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 VLPFGLGPDG---------HHVDAIQSAPAPSAPP-AHMMPPAYARGQTNIYTGVPIIVNPYIDF 158
            :|..|||..|         |:.........||.|| .|......|.....::.|
Human   103 LLTRGLGGRGGGCQRQEFAHYTVGTGQGKLPSTPPTTHSTGAGSADSGCGVWAG----------- 156

  Fly   159 IVVNGDDRYMIRCE------------------RKSVLERSV--ELAKLIHAGPNSGRKSDNHFQI 203
                |.:|....|:                  ..|.|||:|  ...|.::.       |....|.
Human   157 ----GTERGGFLCQVPVSFPLLLTGSLPALPHTHSGLERNVCPHREKYVYL-------SQLCLQF 210

  Fly   204 LNVDKNDFELIVRYMEKHFIPYRDHKHLLKILELSDRFNVPDLIIYCIRELD------------L 256
            : |...|.:|:...::..:.|.|..:      |::..|.:..|...|:..::            |
Human   211 V-VKVLDVDLVCEALQHFWRPRRADQ------EVAVTFGLGQLQERCVAFIEAHSQEALRTRGFL 268

  Fly   257 RISSATALDIFKA---------------LWFYQGIALTNQHQTVITTQETGQQLARKKATKAKAA 306
            .:|:|..|.:.::               .|...|.|:                |.|..|..|...
Human   269 ELSAAALLPLLRSDKLCVDEAELVRAARSWARVGAAV----------------LERPVAEVAAPV 317

  Fly   307 AKQLAAAKASQSTENGAEGDGAQQNLIP------NPNPFT 340
            .|:|..|..:.:..:..|....|:.|||      .|.|.:
Human   318 VKELRLALLAPAELSALEEQNRQEPLIPVGTRGTGPAPLS 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
axed	NP_001356975.1	BTB	<192..258	CDD:197585	12/77 (16%)
axed	NP_001356975.1	BACK	<354..423	CDD:355779
BTBD19	XP_016855936.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156836
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930