Protein Alignment Mdr65 and ATM1

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_014030.1
• Gene: ATM1 / 855347
• SGDID: S000004916
• Length: 690
• Species: Saccharomyces cerevisiae
• Alignment Length: 546
• Identity: 168/546 - (30%)
• Similarity: 281/546 - (51%)
• Gaps: 63/546 - (11%)

  Fly   121 GILLTIASVVMFISGIFSV---DVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMV 182
            |:.:....|..|.|.:|..   .||..||...:..:.::.|..:::.|:|||  .|:|  |..:.
Yeast   155 GLTILCYGVARFGSVLFGELRNAVFAKVAQNAIRTVSLQTFQHLMKLDLGWH--LSRQ--TGGLT 215

  Fly   183 DDVEKIRDGISEKVGHFVY--LVVGFIITVA---ISFSYGWKLTLAVSSYIPLVILLNYYVAKFQ 242
            ..:::...|||:.:...|:  :.:.|.|:|.   :::.:|     |..:.|....:|.|.:  |.
Yeast   216 RAMDRGTKGISQVLTAMVFHIIPISFEISVVCGILTYQFG-----ASFAAITFSTMLLYSI--FT 273

  Fly   243 GKLTA-----REQESYAG--AGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPAR----KASQW 296
            .|.||     |...:.|.  |.::|.:.|.:...|..|..||....:|...|:..|    |.||
Yeast   274 IKTTAWRTHFRRDANKADNKAASVALDSLINFEAVKYFNNEKYLADKYNGSLMNYRDSQIKVSQ- 337

  Fly   297 KGAF--SG---LSDAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGIIVGADN 356
            ..||  ||   :....|.:|:|:.|.|..  |.||.:.|..:.|:......:.:.|.|.:.  .:
Yeast   338 SLAFLNSGQNLIFTTALTAMMYMGCTGVI--GGNLTVGDLVLINQLVFQLSVPLNFLGSVY--RD 398

  Fly   357 IARTAPFLESFATARGCATNLFKV----IDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSR 417
            :.::...:|:          |||:    :.:.:...||     :|...:..|:.|::|.|.|  .
Yeast   399 LKQSLIDMET----------LFKLRKNEVKIKNAERPL-----MLPENVPYDITFENVTFGY--H 446

  Fly   418 PEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSN 482
            |:..:.:..:..|.||...|:|||||.||||.::|:.|||||..|.:|::..||::|:|..||..
Yeast   447 PDRKILKNASFTIPAGWKTAIVGSSGSGKSTILKLVFRFYDPESGRILINGRDIKEYDIDALRKV 511

  Fly   483 IAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGG 547
            |.||.|:..||..||.:|:.:|:..||.:|:.....:|.....|..||:.:.:::||||..:|||
Yeast   512 IGVVPQDTPLFNDTIWENVKFGRIDATDEEVITVVEKAQLAPLIKKLPQGFDTIVGERGLMISGG 576

  Fly   548 QKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQAL--DLASKGRTTIVVSHRLSAIRGADK 610
            :|||:||||.|::|.:|:..||||||||..:|:.:.:.:  :..|..||::.::|||..|..|||
Yeast   577 EKQRLAIARVLLKNARIMFFDEATSALDTHTEQALLRTIRDNFTSGSRTSVYIAHRLRTIADADK 641

  Fly   611 IVFIHDGKVLEEGSHDDLMALEGAYY 636
            |:.:.:|:|.|||.|.:|:|:.|:.|
Yeast   642 IIVLDNGRVREEGKHLELLAMPGSLY 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	168/546 (31%)
		MdlB	711..1299	CDD:440747
ATM1	NP_014030.1	ATM1	81..674	CDD:444078	168/546 (31%)