Protein Alignment Mdr65 and MDL1

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_013289.1
• Gene: MDL1 / 850885
• SGDID: S000004178
• Length: 695
• Species: Saccharomyces cerevisiae
• Alignment Length: 685
• Identity: 200/685 - (29%)
• Similarity: 321/685 - (46%)
• Gaps: 99/685 - (14%)

  Fly    18 EAPMAEGLEPTEPIAFLKL----FRFSTYGEIGWLFFGFIMCC--IKALTLPAVVIIYSEFTSML 76
            ::.:|:|.:.|:|.  |||    .:.|.:.:|..|   |::..  .|.:.|..::|:.|...||.
Yeast    60 QSDIAQGKKSTKPT--LKLSNANSKSSGFKDIKRL---FVLSKPESKYIGLALLLILISSSVSMA 119

  Fly    77 VDRAMQFGTSSNVHALPLFGGGKTLTNASRE--ENNEALYDDSISYGI----LLTIASVVMFISG 135
            |...:                ||.|..||..  |:.|....:.: ||.    ..|....|..|..
Yeast   120 VPSVI----------------GKLLDLASESDGEDEEGSKSNKL-YGFTKKQFFTALGAVFIIGA 167

  Fly   136 IFS---VDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKVG 197
            :.:   :.:..:...|.|.|:|.:...:.:.||..:.|.....:....:..|...:...:::.|.
Yeast   168 VANASRIIILKVTGERLVARLRTRTMKAALDQDATFLDTNRVGDLISRLSSDASIVAKSVTQNVS 232

  Fly   198 HFVYLVV-GFIITVAISFSYGWKLTLAVSSYI-PLVILLNYYVAKFQGKLTAREQESYAGAGNLA 260
            .....:: ||:....:|| ..||||..:.... ||..:...|..|.: .|:.:.|.|..|...:|
Yeast   233 DGTRAIIQGFVGFGMMSF-LSWKLTCVMMILAPPLGAMALIYGRKIR-NLSRQLQTSVGGLTKVA 295

  Fly   261 EEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFS-GLSDAVLKSMLY----------- 313
            ||.|::.||:.::||||:||:||         |.:.:..|. ||.:||...:.:
Yeast   296 EEQLNATRTIQAYGGEKNEVRRY---------AKEVRNVFHIGLKEAVTSGLFFGSTGLVGNTAM 351

  Fly   314 LSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLF 378
            ||.         |::....:::...|...|.......:....::...:.|........|.|..:|
Yeast   352 LSL---------LLVGTSMIQSGSMTVGELSSFMMYAVYTGSSLFGLSSFYSELMKGAGAAARVF 407

  Fly   379 KVIDLTSKI------DPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVA 437
            ::.|....|      ||:|...|        .:.|::|.|.||:||:..:.:.|||.|:.|:.|.
Yeast   408 ELNDRKPLIRPTIGKDPVSLAQK--------PIVFKNVSFTYPTRPKHQIFKDLNITIKPGEHVC 464

  Fly   438 LVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNIS 502
            .||.||.||||...||.|:||...||:...|.|||.:|::..|..|..|.|||:||.|||..||.
Yeast   465 AVGPSGSGKSTIASLLLRYYDVNSGSIEFGDEDIRNFNLRKYRRLIGYVQQEPLLFNGTILDNIL 529

  Fly   503 YGKPGATQKE---IEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKI 564
            |..|....::   |..|..:|...:|:.|.|:..::|:|.||:|||||||||||:|||.:.:|.:
Yeast   530 YCIPPEIAEQDDRIRRAIGKANCTKFLANFPDGLQTMVGARGAQLSGGQKQRIALARAFLLDPAV 594

  Fly   565 LLLDEATSALDYQSEKQVQQALD-LASKGRTTIVVSHRLSAIRGADKIVFI-HDGKVLEEGSHDD 627
            |:|||||||||.|||:.|.:.|. ...:|.|||.::||||.|:.:.:::.: ..|.|:|.||..|
Yeast   595 LILDEATSALDSQSEEIVAKNLQRRVERGFTTISIAHRLSTIKHSTRVIVLGKHGSVVETGSFRD 659

  Fly   628 LMALEGAYYNMV---------RAGDINMPDEVEKE 653
            |:|:..:..|.:         :.|.|::.:.|.:|
Yeast   660 LIAIPNSELNALLAEQQDEEGKGGVIDLDNSVARE 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	171/563 (30%)
		MdlB	711..1299	CDD:440747
MDL1	NP_013289.1	MdlB	82..679	CDD:440747	189/644 (29%)