Protein Alignment Mdr65 and ABCB14

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_174122.1
• Gene: ABCB14 / 839694
• AraportID: AT1G28010
• Length: 1247
• Species: Arabidopsis thaliana
• Alignment Length: 1308
• Identity: 469/1308 - (35%)
• Similarity: 701/1308 - (53%)
• Gaps: 92/1308 - (7%)

  Fly     9 SSSEGKSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFT 73
            :.:|.|.:|:..|.:     |.::.:.||..:...:...:|.|.:..||...|||    ::..|.
plant    14 AETEVKKEEKKKMKK-----ESVSLMGLFSAADNVDYFLMFLGGLGTCIHGGTLP----LFFVFF 69

  Fly    74 SMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISGIFS 138
            ..::|...:..|..|             ..:||...| |||         |....:|..:|....
plant    70 GGMLDSLGKLSTDPN-------------AISSRVSQN-ALY---------LVYLGLVNLVSAWIG 111

  Fly   139 VDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDL-ASKQNFTQSMVDDVEKIRDGISEKVGHFVYL 202
            |..:.....||..|:||....|::.:||.:.|. |...||...:..|...::|.|.:|.||.:..
plant   112 VACWMQTGERQTARLRINYLKSILAKDITFFDTEARDSNFIFHISSDAILVQDAIGDKTGHVLRY 176

  Fly   203 VVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSI 267
            :..||....|.|...|:|||.....:||:.:.....|.....::.:.:.:||.||.:|||::|.:
plant   177 LCQFIAGFVIGFLSVWQLTLLTLGVVPLIAIAGGGYAIVMSTISEKSEAAYADAGKVAEEVMSQV 241

  Fly   268 RTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRN 332
            |||.:|.||:..|:.|.|.|..|.|.|:..|...||...:..|:|:.:.|..|||...|:...:.
plant   242 RTVYAFVGEEKAVKSYSNSLKKALKLSKRSGLAKGLGVGLTYSLLFCAWALLFWYASLLVRHGKT 306

  Fly   333 VENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDGKLL 397
            ...|.:| .||.:.:.|..:|     :..|.|.:.:..|..|.|:||:|...:    |.:..:|.
plant   307 NGAKAFT-TILNVIYSGFALG-----QAVPSLSAISKGRVAAANIFKMIGNNN----LESSERLE 361

  Fly   398 N----YGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYD 458
            |    ..:.|.:||..|.|.|||||. :|...|:..|.:|:|.|.||.||.||||.:.::||||:
plant   362 NGTTLQNVVGKIEFCGVSFAYPSRPN-MVFENLSFTIHSGKTFAFVGPSGSGKSTIISMVQRFYE 425

  Fly   459 PVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAH 523
            |..|.:|||..||:...::|||..:.:|.|||.||..|||.||..||..|...:|..||..|.|.
plant   426 PRSGEILLDGNDIKNLKLKWLREQMGLVSQEPALFATTIASNILLGKEKANMDQIIEAAKAANAD 490

  Fly   524 EFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDL 588
            .||.:||..|.:.:||.|:|||||||||||||||:::|||||||||||||||.:|||.||||||.
plant   491 SFIKSLPNGYNTQVGEGGTQLSGGQKQRIAIARAVLRNPKILLLDEATSALDAESEKIVQQALDN 555

  Fly   589 ASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVRAGDINMPDEVEKE 653
            ..:.|||||::||||.||..||||.:.||:|.|.|||.:|::..|.|..:|...|      .|.:
plant   556 VMEKRTTIVIAHRLSTIRNVDKIVVLRDGQVRETGSHSELISRGGDYATLVNCQD------TEPQ 614

  Fly   654 DSIEDTKQKSLALFEKSFETSPLNFEKGQKNSVQFEEPIIKALIKDTNAQSAEAPPEKPNFFRTF 718
            :::.....:|......|:.:..: |...:.:|  |.|          :.:..|...:..:...:.
plant   615 ENLRSVMYESCRSQAGSYSSRRV-FSSRRTSS--FRE----------DQEKTEKDSKGEDLISSS 666

  Fly   719 SRILQLAK---QEWCYLILGTISAVAVGFLYPA-----FAVIFGEFYAALAEKDPEDALRRTAVL 775
            |.|.:|.|   .||.|.:||:|.||..| ..||     .|.:...||:..    |....|....:
plant   667 SMIWELIKLNAPEWLYALLGSIGAVLAG-SQPALFSMGLAYVLTTFYSPF----PSLIKREVDKV 726

  Fly   776 SWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSG 840
            :...:|...:|..:..||.|.:...|..||:|:|...|:|:::.|:||||.:.|:.|:|::.|:.
plant   727 AIIFVGAGIVTAPIYILQHYFYTLMGERLTSRVRLSLFSAILSNEIGWFDLDENNTGSLTSILAA 791

  Fly   841 EAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVR 905
            :|..::.||...||.::|.||..|:::::|.:|:|::|.:..|..|:::.:.:.|...:......
plant   792 DATLVRSAIADRLSTIVQNLSLTITALALAFFYSWRVAAVVTACFPLLIAASLTEQLFLKGFGGD 856

  Fly   906 EKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQR--VEVLIRQKLRWRGVLNSTMQAS 968
            ..:....|..:|.|:|:||||||....|..:..::|.|:.:  ...|:|..:...|.  ...|..
plant   857 YTRAYSRATSLAREAISNIRTVAAFSAEKQISEQFTCELSKPTKSALLRGHISGFGY--GLSQCL 919

  Fly   969 AFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILD 1033
            ||.:||:.|.|..||:...:..|:|.||....||..:..:|::||.||.......|...:|::|.
plant   920 AFCSYALGLWYISVLIKRNETNFEDSIKSFMVLLVTAYSVAETLALTPDIVKGTQALGSVFRVLH 984

  Fly  1034 RKPKIQSPMGTIKNTLAKQLNLFEGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGC 1098
            |:.:|  |.....:.|...:.  ..:.:|.:.|.|||||:..|...|:|.|..|:::|:||.||.
plant   985 RETEI--PPDQPNSRLVTHIK--GDIEFRNVSFAYPTRPEIAIFKNLNLRVSAGKSLAVVGPSGS 1045

  Fly  1099 GKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRR 1163
            ||||.:.|:.|:|||..|.:.||..||: .:.|..:|.||.:|.|||.||..||.|||.||:  .
plant  1046 GKSTVIGLIMRFYDPSNGNLCIDGHDIK-SVNLRSLRKKLALVQQEPALFSTSIHENIKYGN--E 1107

  Fly  1164 SVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEAT 1228
            :.|..|||.|||:||||.||..:..||.|.:|.:|.|||||||||:|||||::::|.:|||||||
plant  1108 NASEAEIIEAAKAANAHEFISRMEEGYMTHVGDKGVQLSGGQKQRVAIARAVLKDPSVLLLDEAT 1172

  Fly  1229 SALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQG-GIY 1292
            ||||..:|:.||:|||....|||.|::||||||::.||.|.|:..|:|||:|:|.:|:|:. |.|
plant  1173 SALDTSAEKQVQEALDKLMKGRTTILVAHRLSTIRKADTIVVLHKGKVVEKGSHRELVSKSDGFY 1237

  Fly  1293 AKLHKTQK 1300
            .||...|:
plant  1238 KKLTSLQE 1245

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	211/527 (40%)
		MdlB	711..1299	CDD:440747	224/598 (37%)
ABCB14	NP_174122.1	PTZ00265	47..1243	CDD:240339	461/1266 (36%)