Protein Alignment Mdr65 and ABCB13

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_174115.1
• Gene: ABCB13 / 839687
• AraportID: AT1G27940
• Length: 1245
• Species: Arabidopsis thaliana
• Alignment Length: 1314
• Identity: 473/1314 - (35%)
• Similarity: 698/1314 - (53%)
• Gaps: 100/1314 - (7%)

  Fly    10 SSEGKSQEEAPMAEGLE--PTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEF 72
            ||.|..|.|....|..:  ..|.::.:.||..:...:...:..|.:..||...|||...:.:.:.
plant     7 SSNGNIQAETEAKEEKKNIKKESVSLMGLFSAADKLDYFLMLLGGLGACIHGATLPLFFVFFGKM 71

  Fly    73 TSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISGIF 137
            ...|          .|:...|     |.:  :||...| |||         |....:|.|:|...
plant    72 LDSL----------GNLSTDP-----KAI--SSRVSQN-ALY---------LVYLGLVNFVSAWI 109

  Fly   138 SVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDL-ASKQNFTQSMVDDVEKIRDGISEKVGHFVY 201
            .|..:.....||..|:||....|::.:||.:.|. |...|....:..|...::|.|.:|..|.:.
plant   110 GVSCWMQTGERQTARLRINYLKSILAKDITFFDTEARDSNLIFHISSDAILVQDAIGDKTDHVLR 174

  Fly   202 LVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSS 266
            .:..||....|.|...|:|||.....:||:.:.....|.....::.:.:.:||.||.:|||::|.
plant   175 YLSQFIAGFVIGFLSVWQLTLLTLGVVPLIAIAGGGYAIVMSTISEKSETAYADAGKVAEEVMSQ 239

  Fly   267 IRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDDR 331
            :|||.:|.||:..|:.|.|.|..|.|..:..|...||...:..|:|:.:.|...||...|:...:
plant   240 VRTVYAFVGEEKAVKSYSNSLKKALKLGKRSGLAKGLGVGLTYSLLFCAWALLLWYASLLVRHGK 304

  Fly   332 NVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVI-----DLTSKIDPLS 391
            ....|.:| .||.:.|.|..:|     :.||.|.:.|..|..|.|:|::|     :.:.::|
plant   305 TNGAKAFT-TILNVIFSGFALG-----QAAPSLSAIAKGRVAAANIFRMIGNNNSESSQRLD--- 360

  Fly   392 TDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRF 456
             :|..|. .:.|.:|||.|.|.|||||. :|...|:..||:|:|.|.||.||.||||.:.::|||
plant   361 -EGTTLQ-NVAGRIEFQKVSFAYPSRPN-MVFENLSFTIRSGKTFAFVGPSGSGKSTIISMVQRF 422

  Fly   457 YDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAG 521
            |:|..|.:|||..||:...::|.|..:.:|.|||.||..|||.||..||..|...:|..||..|.
plant   423 YEPNSGEILLDGNDIKSLKLKWFREQLGLVSQEPALFATTIASNILLGKENANMDQIIEAAKAAN 487

  Fly   522 AHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQAL 586
            |..||.:||..|.:.:||.|:|||||||||||||||:::|||||||||||||||.:|||.|||||
plant   488 ADSFIKSLPNGYNTQVGEGGTQLSGGQKQRIAIARAVLRNPKILLLDEATSALDAESEKIVQQAL 552

  Fly   587 DLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVRAGDINMPDEVE 651
            |...:.||||||:||||.||..||||.:.||:|.|.|||.:||...|.|..:|...:.. |.|..
plant   553 DNVMEKRTTIVVAHRLSTIRNVDKIVVLRDGQVRETGSHSELMLRGGDYATLVNCQETE-PQENS 616

  Fly   652 KEDSIEDTKQK----SLALFEKSFETSPLNFEKGQKNSVQFEEPIIKALIKDTNAQSAEAPPEKP 712
            :....|..|.:    |......|..||  :|...|:              |..|..|.:.
plant   617 RSIMSETCKSQAGSSSSRRVSSSRRTS--SFRVDQE--------------KTKNDDSKKD----- 660

  Fly   713 NFFRTFSRILQLAK---QEWCYLILGTISAVAVGFLYPAF----AVIFGEFYAALAEKDPEDALR 770
              |.:.|.|.:|.|   .||.|.:||:|.||..|...|.|    |.:...||:........| :.
plant   661 --FSSSSMIWELIKLNSPEWPYALLGSIGAVLAGAQTPLFSMGIAYVLTAFYSPFPNVIKRD-VE 722

  Fly   771 RTAVLSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALS 835
            :.|::   ..|...:|..:..||.|.:...|..||:|:|...|:|:::.|:||||.:.|:.|:|:
plant   723 KVAII---FAGAGIVTAPIYLLQHYFYTLMGERLTSRVRLSLFSAILSNEIGWFDLDENNTGSLT 784

  Fly   836 ARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMS 900
            :.|:.:|..::.|:...||.::|.||..::::::|.:|:|::|.:..|..|:::.:.:.|...:.
plant   785 SILAADATLVRSALADRLSTIVQNLSLTVTALALAFFYSWRVAAVVTACFPLLIAASLTEQLFLK 849

  Fly   901 NAVVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQR--VEVLIRQKLRWRGVLNS 963
            .......:....|..:|.|:|.||||||....|..:..::|.|:.:  ....:|..:...|.  .
plant   850 GFGGDYTRAYSRATSVAREAIANIRTVAAYGAEKQISEQFTCELSKPTKNAFVRGHISGFGY--G 912

  Fly   964 TMQASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRL 1028
            ..|..||.:||:.|.|..||::..:..|.|.||....|:..:..::::||.||.......|...:
plant   913 LSQFLAFCSYALGLWYVSVLINHKETNFGDSIKSFMVLIVTAFSVSETLALTPDIVKGTQALGSV 977

  Fly  1029 FQILDRKPKIQSPMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVAL 1092
            |::|.|:.|| ||    ....::.::..:| :.:|.:.|.|||||:..|...|:|.|..|:::|:
plant   978 FRVLHRETKI-SP----DQPNSRMVSQVKGDIEFRNVSFVYPTRPEIDIFKNLNLRVSAGKSLAV 1037

  Fly  1093 VGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIA 1157
            ||.||.||||.:.|:.|:|||..|.:.||..||: .|.|..:|.||.:|.|||.||..:|.|||.
plant  1038 VGPSGSGKSTVIGLIMRFYDPSNGNLCIDGQDIK-TLNLRSLRKKLALVQQEPALFSTTIYENIK 1101

  Fly  1158 YGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKIL 1222
            ||:  .:.|..||:.|||:||||.|||.:..||.|..|.:|.|||||||||:|||||::::|.:|
plant  1102 YGN--ENASEAEIMEAAKAANAHEFIIKMEEGYKTHAGDKGVQLSGGQKQRVAIARAVLKDPSVL 1164

  Fly  1223 LLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLIS 1287
            ||||||||||..||:|||:|||....|||.:::||||||::.||.:.|:..|:|||:|:|.:|:|
plant  1165 LLDEATSALDTSSEKLVQEALDKLMKGRTTVLVAHRLSTIRKADTVAVLHKGRVVEKGSHRELVS 1229

  Fly  1288 -QGGIYAKLHKTQK 1300
             ..|.|.:|...|:
plant  1230 IPNGFYKQLTSLQE 1243

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	213/528 (40%)
		MdlB	711..1299	CDD:440747	221/598 (37%)
ABCB13	NP_174115.1	PTZ00265	54..1241	CDD:240339	462/1263 (37%)