Protein Alignment Mdr65 and ABCB12

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_171754.1
• Gene: ABCB12 / 839282
• AraportID: AT1G02530
• Length: 1273
• Species: Arabidopsis thaliana
• Alignment Length: 1345
• Identity: 486/1345 - (36%)
• Similarity: 736/1345 - (54%)
• Gaps: 130/1345 - (9%)

  Fly     2 ERDEVSTSSSEGKSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVV 66
            |.|.||...|..|:.|:|         :.:...|||.|:...::..:..|.:......:.||.:.
plant     8 EGDSVSHEHSTSKTDEKA---------KTVPLYKLFAFADSFDVFLMICGSLGAIGNGVCLPLMT 63

  Fly    67 IIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVM 131
            :::.:    |:|   .||                     :.:||:.:.|         .::.|.:
plant    64 LLFGD----LID---SFG---------------------KNQNNKDIVD---------VVSKVCL 91

  Fly   132 -FI--------SGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQ-NFTQSMVDDVE 186
             |:        :....|..:.:...||..::|.....:::|||||:.|:.:.. .....|..|..
plant    92 KFVYLGLGRLGAAFLQVACWMITGERQAAKIRSNYLKTILRQDIGFFDVETNTGEVVGRMSGDTV 156

  Fly   187 KIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQE 251
            .|:|.:.||||.|:.||..|:...|::|:.||.|||.:.:.||.:.:....:|....:.::|.|.
plant   157 HIQDAMGEKVGKFIQLVSTFVGGFALAFAKGWLLTLVMLTSIPFLAMAGAAMALLVTRASSRGQA 221

  Fly   252 SYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSC 316
            :||.|..:.|:.:.|||||.||.|||..:..|:.::..|.|:|..:|..:||...|:..:.:.|.
plant   222 AYAKAATVVEQTIGSIRTVASFTGEKQAINSYKKYITSAYKSSIQQGFSTGLGLGVMIYVFFSSY 286

  Fly   317 AGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVI 381
            |.|.|:|..:|::      |.||...::.....::.|:.::.:|:|.:.:||..:..|..:|:.|
plant   287 ALAIWFGGKMILE------KGYTGGSVINVIIIVVAGSMSLGQTSPCVTAFAAGQAAAYKMFETI 345

  Fly   382 DLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGK 446
            .....||....:||:|. .:|||:|.:||.|.||:||:..:..|.::.|.:|.|.||||.||.||
plant   346 KRKPLIDAYDVNGKVLG-DIRGDIELKDVHFSYPARPDEEIFDGFSLFIPSGATAALVGESGSGK 409

  Fly   447 STCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQK 511
            ||.:.|::|||||..|.||:|.::::::.::|:||.|.:|.||||||..:|.:||:|||..||.:
plant   410 STVINLIERFYDPKAGEVLIDGINLKEFQLKWIRSKIGLVCQEPVLFSSSIMENIAYGKENATLQ 474

  Fly   512 EIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDY 576
            ||:.|...|.|.:||.|||:...:.:||.|:|||||||||||||||::::|::|||||||||||.
plant   475 EIKVATELANAAKFINNLPQGLDTKVGEHGTQLSGGQKQRIAIARAILKDPRVLLLDEATSALDT 539

  Fly   577 QSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMA-LEGAYYNMVR 640
            :||:.||:|||.....|||:||:||||.:|.||.|..||.||::|:|||.:|:. ..|||..::|
plant   540 ESERVVQEALDRVMVNRTTVVVAHRLSTVRNADMIAVIHSGKMVEKGSHSELLKDSVGAYSQLIR 604

  Fly   641 AGDINMPDEVEKEDSIEDTKQKSLALFEKSFETSPLNFEKGQK----------NSVQFEEPIIKA 695
            ..:||...:.:..|....:          ||..|.||..:...          ||.:.....:..
plant   605 CQEINKGHDAKPSDMASGS----------SFRNSNLNISREGSVISGGTSSFGNSSRHHSLNVLG 659

  Fly   696 LI--------------KDTNAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLY 746
            |.              ::|...|.| |..|.    :.:||..|.|.|...|:|||:.|...|.::
plant   660 LFAGLDLGSGSQRVGQEETGTTSQE-PLRKV----SLTRIAALNKPEIPVLLLGTVVAAINGAIF 719

  Fly   747 PAFAVIFGEFYAALAEKDPEDALRRTAVLSWACLGLAF-LTGLVCF-LQTYLFNYAGIWLTTRMR 809
            |.|.::......|..:  |.|.|::.:.. ||.:.:|. :|.|:.. .|.|||..||..|..|::
plant   720 PLFGILISRVIEAFFK--PADQLKKDSRF-WAIIFVALGVTSLIVSPSQMYLFAVAGGKLIRRIQ 781

  Fly   810 AMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYN 874
            :|.|...|:.||.|||:..||.|.:.||||.:|..|:..:|..||..:|..::..|.:.:|...:
plant   782 SMCFEKAVHMEVSWFDEPENSSGTMGARLSTDAALIRALVGDALSLAVQNAASAASGLIIAFTAS 846

  Fly   875 WKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTVAGLRREADVIRE 939
            |:|||:.|...|:|..:..|:.|.|.......|...|||.::|.:::.:|||||....|..|::.
plant   847 WELALIILVMLPLIGINGFLQVKFMKGFSADAKSKYEEASQVANDAVGSIRTVASFCAEEKVMQM 911

  Fly   940 YTEEIQRVEVLIRQKLRWRGVLNSTMQASAFF----AYAVALCYGGVLVSEGQLPFQDIIKVSET 1000
            |.::   .|..|:..:: :|.::......:||    .||.:......||.:|:..|.|:.:|...
plant   912 YNKQ---CEGPIKDGVK-QGFISGLGFGFSFFILFCVYATSFYAAARLVEDGKTTFIDVFQVFFA 972

  Fly  1001 LLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKIQS--PMGTIKNTLAKQLNLFEGVRYRG 1063
            |...::.::||..|.|..|.|.:|...:|.|:|||.||.|  ..||:...:...:.|      |.
plant   973 LTMAAIGISQSSTFAPDSSKAKVAAASIFAIIDRKSKIDSSDETGTVLENVKGDIEL------RH 1031

  Fly  1064 IQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHD 1128
            :.|.||.||..:|...|.|.:..|:||||||.||.||||.:.||||:||||.|.|.:|..::: .
plant  1032 LSFTYPARPGIQIFRDLCLTIRAGKTVALVGESGSGKSTVISLLQRFYDPDSGQITLDGVELK-K 1095

  Fly  1129 LTLDGVRTKLGIVSQEPTLFERSIAENIAYG-DNRRSVSMVEIIAAAKSANAHSFIISLPNGYDT 1192
            |.|..:|.::|:|.|||.||..:|..||||| .:..:.:..||||||:.||||.||.|:..||||
plant  1096 LQLKWLRQQMGLVGQEPVLFNDTIRANIAYGKGSEEAATESEIIAAAELANAHKFISSIQQGYDT 1160

  Fly  1193 RMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAH 1257
            .:|.:|.|||||||||:|||||:|:.||||||||||||||.:||:|||.|||.....||.:|:||
plant  1161 VVGEKGIQLSGGQKQRVAIARAIVKEPKILLLDEATSALDAESERLVQDALDRVIVNRTTVVVAH 1225

  Fly  1258 RLSTVQNADVICVIQNGQVVEQGNHMQLIS-QGGIYA---KLHKT 1298
            ||||::|||||.:::||.:.|.|.|..||. .||:||   :||.|
plant  1226 RLSTIKNADVIAIVKNGVIAENGTHETLIKIDGGVYASLVQLHMT 1270

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	206/533 (39%)
		MdlB	711..1299	CDD:440747	242/601 (40%)
ABCB12	NP_171754.1	PTZ00265	3..1267	CDD:240339	483/1340 (36%)
		MdlB	690..1272	CDD:440747	241/595 (41%)