Protein Alignment Mdr65 and ABCB7

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_199466.1
• Gene: ABCB7 / 834697
• AraportID: AT5G46540
• Length: 1248
• Species: Arabidopsis thaliana
• Alignment Length: 1291
• Identity: 484/1291 - (37%)
• Similarity: 717/1291 - (55%)
• Gaps: 94/1291 - (7%)

  Fly    31 IAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLVDRAMQFGTSSNVHALPLF 95
            |||.|||.|:...:|..:..|.:......||.|.:.|:..:..::       ||.|.:.|..
plant    18 IAFYKLFTFADRYDIVLMVIGTLSAMANGLTQPFMSILMGQLINV-------FGFSDHDHVF--- 72

  Fly    96 GGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISGIFSVDVFNMVALRQVTRMRIKLFSS 160
                      :|.:..|     :.:..|...|.||.|:    .|..:.:...||.||:|.....:
plant    73 ----------KEVSKVA-----VKFLYLAAYAGVVSFL----QVSCWMVTGERQSTRIRRLYLKT 118

  Fly   161 VIRQDIGWHDLASKQ-NFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTLAV 224
            ::|||||:.|..:.. .....|..|...|:|.:.||||.|..||..|:....::|..|.|||||:
plant   119 ILRQDIGFFDTETNTGEVIGRMSGDTILIQDSMGEKVGKFTQLVSSFVGGFTVAFIVGMKLTLAL 183

  Fly   225 SSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVP 289
            ...:||::.....:.....|...|.|.:|..|||:.::.:.||||||:|.|||..:.:||..|..
plant   184 LPCVPLIVGTGGAMTYIMSKKAQRVQLAYTEAGNVVQQAVGSIRTVVAFTGEKQSMGKYEKKLEI 248

  Fly   290 ARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGIIVGA 354
            |.|:...:|.:|||...::..::|.:...|.|||...||:      |.||...:|.....|:.|.
plant   249 AYKSMVKQGLYSGLGIGIMMVVVYCTYGFAIWYGARQIIE------KGYTGGQVMNVITSILTGG 307

  Fly   355 DNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPE 419
            ..:.:|.|.|.|||.....|..:|:.|....|||.....|::|. .::||:|.:||:||||:||:
plant   308 MALGQTLPSLNSFAAGTAAAYKMFETIKRKPKIDAYDMSGEVLE-EIKGDIELRDVYFRYPARPD 371

  Fly   420 VIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIA 484
            |.:..|.::.:..|.||||||.||.||||.:.|::|||||..|.||:|.:|::|:.::|:||.|.
plant   372 VQIFVGFSLTVPNGMTVALVGQSGSGKSTVISLIERFYDPESGEVLIDGIDLKKFQVKWIRSKIG 436

  Fly   485 VVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQK 549
            :|.|||:||..||.:||.|||..|:.:||..|...|.|..||..||:...:|:||.|:|||||||
plant   437 LVSQEPILFATTIRENIVYGKKDASDQEIRTALKLANASNFIDKLPQGLETMVGEHGTQLSGGQK 501

  Fly   550 QRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFI 614
            ||||||||:::|||||||||||||||.:||:.||.||......|||:||:|||:.||.||.|..:
plant   502 QRIAIARAILKNPKILLLDEATSALDAESERIVQDALVKLMLSRTTVVVAHRLTTIRTADMIAVV 566

  Fly   615 HDGKVLEEGSHDDLMA-LEGAYYNMVRAGDINMPDEVEKEDSIEDTKQKSLALFEKSFETSPLNF 678
            ..|||:|:|:||:::. .||.|..:||     :.:..:||::|:...:|.    |.|.|....:.
plant   567 QQGKVIEKGTHDEMIKDPEGTYSQLVR-----LQEGSKKEEAIDKEPEKC----EMSLEIESSDS 622

  Fly   679 EKGQKNSV--------------QFEEPIIKALIKDTNAQSAEAPPEKPNFFRTFSRILQLAKQEW 729
            :.|..:..              |.||  ....|..|..|:.:...|.     :..|:..|.|.|.
plant   623 QNGIHSGTLTSPSGLPGVISLDQTEE--FHENISSTKTQTVKKGKEV-----SLRRLAHLNKPEI 680

  Fly   730 CYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRRTAVLSWACLGLAF-LTGLVCF-L 792
            ..|:||:::||..|.::|...::.........|  |.:.|:..: |.||.:.:|. ||.|:.. |
plant   681 SVLLLGSLAAVIHGIVFPVQGLLLSRTIRIFFE--PSNKLKNDS-LFWALIFVALGLTDLIVIPL 742

  Fly   793 QTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMI 857
            |.|||..||..|..|:|:::|:.:::|::.||||..||.|.:.||||.:|..::..:|..|..::
plant   743 QNYLFAIAGAKLIKRIRSLSFDRVLHQDISWFDDTKNSSGVIGARLSTDASTVKSIVGDVLGLIM 807

  Fly   858 QALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESIT 922
            |.::..|.:..:|...||.|||:.|...|::......:.|.::....:.:...|||.::|:::::
plant   808 QNMATIIGAFIIAFTANWLLALMALLVAPVMFFQGYYQIKFITGFGAKARGKYEEASQVASDAVS 872

  Fly   923 NIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAYAV--ALCY--GGVL 983
            :|||||....|..|:..|.|:....    :|:....|:::......::.|..|  ::|:  |..|
plant   873 SIRTVASFCAEDKVMDLYQEKCDEP----KQQGFKLGLVSGLCYGGSYLALYVIESVCFLGGSWL 933

  Fly   984 VSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKI--QSPMGTIK 1046
            :...:..|.:..:|...|...::.:.|:....|..:.|..:...:|.|||.||||  .|..|||
plant   934 IQNRRATFGEFFQVFFALTLTAVGVTQTSTMAPDINKAKDSAASIFDILDSKPKIDSSSEKGTI- 997

  Fly  1047 NTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRY 1110
                  |.:..| :..:.:.||||.|||.:|.:.|.|.:..||||||||.||.||||.:.||:|:
plant   998 ------LPIVHGDIELQHVSFRYPMRPDIQIFSDLCLTISSGQTVALVGESGSGKSTVISLLERF 1056

  Fly  1111 YDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAK 1175
            ||||.|.|.:|..:|| .|.|..:|.::|:|||||.||..:|..||||| .....:..|||.|||
plant  1057 YDPDSGKILLDQVEIQ-SLKLSWLREQMGLVSQEPVLFNETIGSNIAYG-KIGGATEEEIITAAK 1119

  Fly  1176 SANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQ 1240
            :||.|:||.|||.||:|.:|.||.|||||||||||||||::::||||||||||||||.:||::||
plant  1120 AANVHNFISSLPQGYETSVGERGVQLSGGQKQRIAIARAILKDPKILLLDEATSALDAESERVVQ 1184

  Fly  1241 QALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLIS-QGGIYAKL 1295
            .|||.....||.:|:||.|:|:::||:|.|::||.:.|.|.|..|:. .||.||.|
plant  1185 DALDQVMVNRTTVVVAHLLTTIKDADMIAVVKNGVIAESGRHETLMEISGGAYASL 1240

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	220/524 (42%)
		MdlB	711..1299	CDD:440747	229/595 (38%)
ABCB7	NP_199466.1	PTZ00265	16..1241	CDD:240339	484/1291 (37%)