Protein Alignment Mdr65 and ABCB5

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_192092.1
• Gene: ABCB5 / 826974
• AraportID: AT4G01830
• Length: 1230
• Species: Arabidopsis thaliana
• Alignment Length: 1282
• Identity: 477/1282 - (37%)
• Similarity: 721/1282 - (56%)
• Gaps: 84/1282 - (6%)

  Fly    28 TEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLVDRAMQFGTSSNVHAL 92
            |:.:.|.|||.||...::..:..|.|......:..|.:.:::.|    |:| ||
plant    10 TKTVPFYKLFFFSDSTDVLLMIVGSIGAIANGVCSPLMTLLFGE----LID-AM----------- 58

  Fly    93 PLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISGIFSVDVFNMVALRQVTRMRIKL 157
                        ...:|||.:.:......:.|....:....:....|..:.:...||..|:|...
plant    59 ------------GPNQNNEEIVERVSKVCLSLVYLGLGALGAAFLQVACWMITGERQAARIRSLY 111

  Fly   158 FSSVIRQDIGWHDL-ASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLT 221
            ..:::|||||:.|: .:.......|..|...|.|.:.||||.|:.|:..|:....|:|..||.||
plant   112 LKTILRQDIGFFDVEMTTGEVVGRMSGDTVLILDAMGEKVGKFIQLISTFVGGFVIAFLRGWLLT 176

  Fly   222 LAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENF 286
            |.:.:.|||:.:....:|....:.:::||.:||.|.|:.|:.|.|||||.||.|||..:..|:..
plant   177 LVMLTSIPLLAMSGAAIAIIVTRASSQEQAAYAKASNVVEQTLGSIRTVASFTGEKQAMSSYKEL 241

  Fly   287 LVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGII 351
            :..|.|::..:|..:||...|:..:.:.:.|...|:|..:|:      .|.||...::.....::
plant   242 INLAYKSNVKQGFVTGLGLGVMFLVFFSTYALGTWFGGEMIL------RKGYTGGAVINVMVTVV 300

  Fly   352 VGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPS 416
            ..:..:.:.:|.|.:|...:..|..:|:.|:....||....:||:|. .:||::|.:||.|.||:
plant   301 SSSIALGQASPCLTAFTAGKAAAYKMFETIEREPLIDTFDLNGKVLE-DIRGEIELRDVCFSYPA 364

  Fly   417 RPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRS 481
            ||:..|..|.::.|.:|.|.||||.||.||||.:.|::|||||..|.||:|.:|::::.::|:|.
plant   365 RPKEEVFGGFSLLIPSGTTTALVGESGSGKSTVISLIERFYDPNSGQVLIDGVDLKEFQLKWIRG 429

  Fly   482 NIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSG 546
            .|.:|.||||||..:|.:||.|||.|||.:||:||:..|.|.:||..||....:::||.|:||||
plant   430 KIGLVSQEPVLFSSSIMENIGYGKEGATVEEIQAASKLANAAKFIDKLPLGLETLVGEHGTQLSG 494

  Fly   547 GQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKI 611
            |||||||||||::::|:||||||||||||.:||:.||:|||.....|||::|:||||.:|.||.|
plant   495 GQKQRIAIARAILKDPRILLLDEATSALDAESERVVQEALDRIMVNRTTVIVAHRLSTVRNADII 559

  Fly   612 VFIHDGKVLEEGSHDDLMA-LEGAYYNMVRAGDINMPDEVEKEDSIEDTKQKSLALFEKSFETSP 675
            ..||.||::|||||.:|:. .||||..::|..:||      ||       .|.|.:.:.|..:..
plant   560 AVIHRGKIVEEGSHSELLKDHEGAYSQLLRLQEIN------KE-------SKRLEISDGSISSGS 611

  Fly   676 LNFEKGQKNSVQFEEPI-IKALI--KDTNAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTI 737
               .:|..::.|.::.. :..|:  :|:...|.|...:.     :|:||..|.|.|...|||||:
plant   612 ---SRGNNSTRQDDDSFSVLGLLAGQDSTKMSQELSQKV-----SFTRIAALNKPEIPILILGTL 668

  Fly   738 SAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRRTAVLS--WACLGLAFLTGLVCFLQTYLFNYA 800
            .....|.::|.|.::|.:...|.. |.|.:..|.:...|  :..||:|.:  :|.....|||..|
plant   669 VGAVNGTIFPIFGILFAKVIEAFF-KAPHELKRDSRFWSMIFVLLGVAAV--IVYPTTNYLFAIA 730

  Fly   801 GIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFIS 865
            |..|..|:|:|.|..:|:.||||||:..||.||:.||||.:|..|:..:|..|...::.:::.::
plant   731 GGRLIRRIRSMCFEKVVHMEVGWFDEPGNSSGAMGARLSADAALIRTLVGDSLCLSVKNVASLVT 795

  Fly   866 SVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTVAGL 930
            .:.:|...:|::|::.|...|.|..:..::.|.|.......|...|||.::|.:::.:|||||..
plant   796 GLIIAFTASWEVAIIILVIIPFIGINGYIQIKFMKGFSADAKAKYEEASQVANDAVGSIRTVASF 860

  Fly   931 RREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFA-YAV-ALCY--GGVLVSEGQLPF 991
            ..|..|:..|.   :|.|..|:..:: :|:::......:||. |:| |.|:  |..||..|:..|
plant   861 CAEEKVMEMYK---KRCEDTIKSGIK-QGLISGVGFGISFFVLYSVYASCFYVGARLVKAGRTNF 921

  Fly   992 QDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKIQS--PMGTIKNTLAKQLN 1054
            .|:.:|...|...::.::|:.:|.|..|....|...:|:|:||..||.|  ..|.:...:...:.
plant   922 NDVFQVFLALTLTAVGISQASSFAPDSSKGKGAAVSIFRIIDRISKIDSRDESGMVLENVKGDIE 986

  Fly  1055 LFEGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIH 1119
            |..      |.|.|.||||.::...|.|.:..||||||||.||.||||.:.||||:||||.|.|.
plant   987 LCH------ISFTYQTRPDVQVFRDLCLSIRAGQTVALVGESGSGKSTVISLLQRFYDPDSGHIT 1045

  Fly  1120 IDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFII 1184
            :|..::: .|.|..:|.::|:|.|||.||..:|..|||||......:..|||||::.||||.||.
plant  1046 LDGVELK-KLRLKWLRQQMGLVGQEPVLFNDTIRANIAYGKGGEEATEAEIIAASELANAHRFIS 1109

  Fly  1185 SLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSG 1249
            |:..||||.:|.||.|||||||||:|||||:|:.||||||||||||||.:||::||.|||.....
plant  1110 SIQKGYDTVVGERGIQLSGGQKQRVAIARAIVKEPKILLLDEATSALDAESERVVQDALDRVMVN 1174

  Fly  1250 RTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLIS-QGGIYAKL 1295
            ||.||:||||||::|||||.|::||.:.|:|.|..||: :||:||.|
plant  1175 RTTIVVAHRLSTIKNADVIAVVKNGVIAEKGTHETLINIEGGVYASL 1221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	206/524 (39%)
		MdlB	711..1299	CDD:440747	239/594 (40%)
ABCB5	NP_192092.1	PTZ00265	2..1224	CDD:240339	477/1282 (37%)