Protein Alignment Mdr65 and ABCB4

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_182223.1
• Gene: ABCB4 / 819314
• AraportID: AT2G47000
• Length: 1286
• Species: Arabidopsis thaliana
• Alignment Length: 1333
• Identity: 508/1333 - (38%)
• Similarity: 748/1333 - (56%)
• Gaps: 102/1333 - (7%)

  Fly     4 DEVSTSSSEGKSQEEAPMAEGL----EPTEPIAFLKLFRFS-----------TYGEIGWLFFGFI 53
            :|||.:..:.:.:||....|..    |.|:.:.|.|||.|:           |.|.||
plant    15 EEVSETKRDKEEEEEVKKTEKKDEEHEKTKTVPFYKLFAFADSFDFLLMILGTLGSIG------- 72

  Fly    54 MCCIKALTLPAVVIIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSI 118
                ..|..|.:.:::.:    |:|                 ..|:..||.:.:.:..||....:
plant    73 ----NGLGFPLMTLLFGD----LID-----------------AFGENQTNTTDKVSKVALKFVWL 112

  Fly   119 SYGILLTIASVVMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDL-ASKQNFTQSMV 182
            ..|   |.|:..:.:||      :.:...||..|:|.....:::||||.:.|: .:.......|.
plant   113 GIG---TFAAAFLQLSG------WMISGERQAARIRSLYLKTILRQDIAFFDIDTNTGEVVGRMS 168

  Fly   183 DDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTA 247
            .|...|:|.:.||||..:.|:..|:....|:|..||.|||.:.|.|||:::....:|....|..:
plant   169 GDTVLIQDAMGEKVGKAIQLLATFVGGFVIAFVRGWLLTLVMLSSIPLLVMAGALLAIVIAKTAS 233

  Fly   248 REQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSML 312
            |.|.:||.|..:.|:.:.|||||.||.|||..:..|...||.|.||...:|..:||....|..::
plant   234 RGQTAYAKAATVVEQTIGSIRTVASFTGEKQAISNYNKHLVTAYKAGVIEGGSTGLGLGTLFLVV 298

  Fly   313 YLSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNL 377
            :.|.|.|.|||..||:|      |.||...::.....::.|:.::.:|:|.|.:||..:..|..:
plant   299 FCSYALAVWYGGKLILD------KGYTGGQVLNIIIAVLTGSMSLGQTSPCLSAFAAGQAAAYKM 357

  Fly   378 FKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSS 442
            |:.|:....||..||:||:|: .::||:|.:||:|.||:||:..:.||.::.|.:|.||||||.|
plant   358 FETIERRPNIDSYSTNGKVLD-DIKGDIELKDVYFTYPARPDEQIFRGFSLFISSGTTVALVGQS 421

  Fly   443 GCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPG 507
            |.||||.|.|::|||||..|.||:|.::::::.::|:||.|.:|.||||||..:|..||:|||..
plant   422 GSGKSTVVSLIERFYDPQAGDVLIDGINLKEFQLKWIRSKIGLVSQEPVLFTASIKDNIAYGKED 486

  Fly   508 ATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATS 572
            ||.:||:|||..|.|.:|:..||:...:|:||.|:|||||||||||:|||::::|:|||||||||
plant   487 ATTEEIKAAAELANASKFVDKLPQGLDTMVGEHGTQLSGGQKQRIAVARAILKDPRILLLDEATS 551

  Fly   573 ALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMA-LEGAYY 636
            |||.:||:.||:|||.....|||:||:||||.:|.||.|..||.||::|:|||.:|:. .||||.
plant   552 ALDAESERVVQEALDRIMVNRTTVVVAHRLSTVRNADMIAVIHQGKIVEKGSHTELLKDPEGAYS 616

  Fly   637 NMVRAGDINMPD----EVEKEDSIEDTKQKSLALFEKSFETSPLNFEKGQK-----NSVQFEEPI 692
            .::|..:....|    |.:|..|||..||.||.........|.....:|..     |...|...|
plant   617 QLIRLQEEKKSDENAAEEQKMSSIESFKQSSLRKSSLGRSLSKGGSSRGNSSRHSFNMFGFPAGI 681

  Fly   693 IKALIKDTNAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFY 757
            ...:::|........|..:|.....| ||..|.|.|...||||:|||.|.|.:.|.|.::.....
plant   682 DGNVVQDQEEDDTTQPKTEPKKVSIF-RIAALNKPEIPVLILGSISAAANGVILPIFGILISSVI 745

  Fly   758 AALAEKDPEDALRRTAVLSWAC--LGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQE 820
            .|..:  |...|:..... ||.  :.|.|.:.:....||:.|..||..|..|:|:|.|..:|:.|
plant   746 KAFFQ--PPKKLKEDTSF-WAIIFMVLGFASIIAYPAQTFFFAIAGCKLVQRIRSMCFEKVVHME 807

  Fly   821 VGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANC 885
            |||||:..||.|.:.||||.:|..|:|.:|..|:..:|.||:.::.:.:|....|:||.:.||..
plant   808 VGWFDEPENSSGTIGARLSADAATIRGLVGDSLAQTVQNLSSILAGLIIAFLACWQLAFVVLAML 872

  Fly   886 PIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVL 950
            |:|..:..|..|.|.......|::..||.::|.:::.:|||||....|..|:..|:   ::.|..
plant   873 PLIALNGFLYMKFMKGFSADAKKMYGEASQVANDAVGSIRTVASFCAEDKVMNMYS---KKCEGP 934

  Fly   951 IRQKLRWRGVLNSTMQASAFF----AYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQS 1011
            ::..:| :|:::......:||    :||.:...|..||.:|:..|..:.:|...|...:|.::||
plant   935 MKNGIR-QGIVSGIGFGFSFFVLFSSYAASFYVGARLVDDGKTTFDSVFRVFFALTMAAMAISQS 998

  Fly  1012 LAFTPAFSAALIAGHRLFQILDRKPKIQSPM--GTIKNTLAKQLNLFEGVRYRGIQFRYPTRPDA 1074
            .:.:|..|.|.:|...:|.|:||:.||...:  |.:.:.:...:.|      |.:.|:||.|||.
plant   999 SSLSPDSSKADVAAASIFAIMDRESKIDPSVESGRVLDNVKGDIEL------RHVSFKYPARPDV 1057

  Fly  1075 KILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLG 1139
            :|...|.|.:..|:||||||.||.||||.:.||||:||||.|.|.:|..:|: .|.|..:|.:.|
plant  1058 QIFQDLCLSIRAGKTVALVGESGSGKSTVIALLQRFYDPDSGEITLDGVEIK-SLRLKWLRQQTG 1121

  Fly  1140 IVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGG 1204
            :|||||.||..:|..|||||.. ...|..||:::|:.:|||.||..|..||||.:|.||.|||||
plant  1122 LVSQEPILFNETIRANIAYGKG-GDASESEIVSSAELSNAHGFISGLQQGYDTMVGERGIQLSGG 1185

  Fly  1205 QKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVIC 1269
            ||||:|||||:|::||:|||||||||||.:||::||.|||.....||.||:||||||::|||||.
plant  1186 QKQRVAIARAIVKDPKVLLLDEATSALDAESERVVQDALDRVMVNRTTIVVAHRLSTIKNADVIA 1250

  Fly  1270 VIQNGQVVEQGNHMQLIS-QGGIYA---KLHKT 1298
            |::||.:||:|.|..||: :.|:||   :||.|
plant  1251 VVKNGVIVEKGKHDTLINIKDGVYASLVQLHLT 1283

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	221/524 (42%)
		MdlB	711..1299	CDD:440747	243/600 (41%)
ABCB4	NP_182223.1	PTZ00265	46..1280	CDD:240339	497/1297 (38%)
		MdlB	705..1285	CDD:440747	242/595 (41%)