Protein Alignment Mdr65 and ABCB1

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_181228.1
• Gene: ABCB1 / 818265
• AraportID: AT2G36910
• Length: 1286
• Species: Arabidopsis thaliana
• Alignment Length: 1314
• Identity: 464/1314 - (35%)
• Similarity: 705/1314 - (53%)
• Gaps: 96/1314 - (7%)

  Fly    17 EEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLVDRAM 81
            ||...||    ...:||.:||||:...:...:..|.:...:...:||.       |.....|...
plant    17 EEPKKAE----IRGVAFKELFRFADGLDYVLMGIGSVGAFVHGCSLPL-------FLRFFADLVN 70

  Fly    82 QFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISGIFSVDVFNMVA 146
            .||::||                    |.|.:.::.:.|.:...:....::.|....:..:....
plant    71 SFGSNSN--------------------NVEKMMEEVLKYALYFLVVGAAIWASSWAEISCWMWSG 115

  Fly   147 LRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMV----DDVEKIRDGISEKVGHFVYLVVGFI 207
            .||.|:||||...:.:.|||.:.|...:   |..:|    .|...::|.||||:|:|::.:..|:
plant   116 ERQTTKMRIKYLEAALNQDIQFFDTEVR---TSDVVFAINTDAVMVQDAISEKLGNFIHYMATFV 177

  Fly   208 ITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVS 272
            ....:.|:..|:|.|...:.:||:.::.........||:.:.|||.:.|||:.|:.:..||.|::
plant   178 SGFIVGFTAVWQLALVTLAVVPLIAVIGGIHTTTLSKLSNKSQESLSQAGNIVEQTVVQIRVVMA 242

  Fly   273 FGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKE 337
            |.||....|.|.:.|..|:|.....|...|:.......:::...|...|||..|:       ...
plant   243 FVGESRASQAYSSALKIAQKLGYKTGLAKGMGLGATYFVVFCCYALLLWYGGYLV-------RHH 300

  Fly   338 YTPAILMIA-FFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDGKLLNYGL 401
            .|...|.|| .|.:::|...:.::||.:.:||.|:..|..:|::||....|:..|..|..|: .:
plant   301 LTNGGLAIATMFAVMIGGLALGQSAPSMAAFAKAKVAAAKIFRIIDHKPTIERNSESGVELD-SV 364

  Fly   402 RGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLL 466
            .|.||.::|.|.|||||:|.:.....:.:.||:|:|||||||.||||.|.|::|||||..|.|||
plant   365 TGLVELKNVDFSYPSRPDVKILNNFCLSVPAGKTIALVGSSGSGKSTVVSLIERFYDPNSGQVLL 429

  Fly   467 DDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPE 531
            |..|::...::|||..|.:|.|||.||..:|.:||..|:|.|.|.|||.||..|.||.||..||:
plant   430 DGQDLKTLKLRWLRQQIGLVSQEPALFATSIKENILLGRPDADQVEIEEAARVANAHSFIIKLPD 494

  Fly   532 SYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTI 596
            .:.:.:||||.|||||||||||||||:::||.||||||||||||.:|||.||:|||....||||:
plant   495 GFDTQVGERGLQLSGGQKQRIAIARAMLKNPAILLLDEATSALDSESEKLVQEALDRFMIGRTTL 559

  Fly   597 VVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMAL--EGAYYNMVRAGDINMPDEVEKEDSIEDT 659
            :::||||.||.||.:..:..|.|.|.|:||:|.:.  .|.|..:::.      .|...|.::.:.
plant   560 IIAHRLSTIRKADLVAVLQQGSVSEIGTHDELFSKGENGVYAKLIKM------QEAAHETAMSNA 618

  Fly   660 KQKSL-ALFEKSFETSPLNFEKGQKNSVQFEEPIIKALIKDTNAQ---SAEAPPEKPNF------ 714
            ::.|. ....::..:||:.    .:||.....|..:.|...:.:.   |.:| ...||:
plant   619 RKSSARPSSARNSVSSPIM----TRNSSYGRSPYSRRLSDFSTSDFSLSIDA-SSYPNYRNEKLA 678

  Fly   715 FR----TFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRRTAVL 775
            |:    :|.|:.::...||.|.:||::.:|..|.|...||.:.....:.....|.|..:::....
plant   679 FKDQANSFWRLAKMNSPEWKYALLGSVGSVICGSLSAFFAYVLSAVLSVYYNPDHEYMIKQIDKY 743

  Fly   776 SWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSG 840
            .:..:||:....:...||...::..|..||.|:|....:|::..|:.|||.|.|....::|||:.
plant   744 CYLLIGLSSAALVFNTLQHSFWDIVGENLTKRVREKMLSAVLKNEMAWFDQEENESARIAARLAL 808

  Fly   841 EAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVR 905
            :|.:::.|||..:|.::|..:..:.:.:......|:|||:.:|..|::|.:.:|:...|:.....
plant   809 DANNVRSAIGDRISVIVQNTALMLVACTAGFVLQWRLALVLVAVFPVVVAATVLQKMFMTGFSGD 873

  Fly   906 EKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNST----MQ 966
            .:....:..::|.|:|.|:||||....||.::|.||..::..    .::..|:|.:..:    .|
plant   874 LEAAHAKGTQLAGEAIANVRTVAAFNSEAKIVRLYTANLEPP----LKRCFWKGQIAGSGYGVAQ 934

  Fly   967 ASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQI 1031
            ...:.:||:.|.|...||..|...|...|:|...|:..:...|::|...|.|.....|...:|::
plant   935 FCLYASYALGLWYASWLVKHGISDFSKTIRVFMVLMVSANGAAETLTLAPDFIKGGQAMRSVFEL 999

  Fly  1032 LDRKPKIQ--SPMGT-IKNTLAKQLNLFEGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALV 1093
            ||||.:|:  .|..| :.:.|..::.|      :.|.|.||:|||.:|...|.|....|:|:|||
plant  1000 LDRKTEIEPDDPDTTPVPDRLRGEVEL------KHIDFSYPSRPDIQIFRDLSLRARAGKTLALV 1058

  Fly  1094 GHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAY 1158
            |.||||||:.:.|:||:|:|..|.:.||..||: ...|..:|..:.||.|||.||..:|.|||||
plant  1059 GPSGCGKSSVISLIQRFYEPSSGRVMIDGKDIR-KYNLKAIRKHIAIVPQEPCLFGTTIYENIAY 1122

  Fly  1159 GDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILL 1223
            |  ....:..|||.||..|:||.||.:||.||.|.:|.||.||||||||||||||||||..:|:|
plant  1123 G--HECATEAEIIQAATLASAHKFISALPEGYKTYVGERGVQLSGGQKQRIAIARALVRKAEIML 1185

  Fly  1224 LDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQ 1288
            |||||||||.:||:.||:|||.||||||.||:||||||::||.||.||.:|:|.|||:|..|:..
plant  1186 LDEATSALDAESERSVQEALDQACSGRTSIVVAHRLSTIRNAHVIAVIDDGKVAEQGSHSHLLKN 1250

  Fly  1289 --GGIYAKLHKTQK 1300
              .||||::.:.|:
plant  1251 HPDGIYARMIQLQR 1264

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	205/529 (39%)
		MdlB	711..1299	CDD:440747	226/606 (37%)
ABCB1	NP_181228.1	MdlB	42..610	CDD:440747	217/611 (36%)
		MdlB	680..1263	CDD:440747	223/595 (37%)