Protein Alignment Mdr65 and TAP2

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_000535.3
• Gene: TAP2 / 6891
• HGNCID: 44
• Length: 703
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 175/520 - (33%)
• Similarity: 269/520 - (51%)
• Gaps: 43/520 - (8%)

  Fly   127 ASVVMFISGIFSV----------DVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSM 181
            ||.:.|:. :||.          ..|.....|...|:|.:||||::|||:|:............:
Human   190 ASAIFFMC-LFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRL 253

  Fly   182 VDDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILL-NYYVAKFQGKL 245
            ..|...:.:.:.......:..:|..:.......|...:|||....::|..|.. ..|..:.|..|
Human   254 SSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHMPFTIAAEKVYNTRHQEVL 318

  Fly   246 TARE-QESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLK 309
              || |::.|.||.:..|.:..::||.|||.|:.||.||:..|...|:. .|:        ..|:
Human   319 --REIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQL-YWR--------RDLE 372

  Fly   310 SMLYLSCAGAFWYGVNLIIDD---RNVENKEYTP-AILMIAFFGIIVGADNIARTAPFLESFATA 370
            ..|||........||.:::..   :.:::.|.|. ::|....:...||  :..:|..::.....:
Human   373 RALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESVG--SYVQTLVYIYGDMLS 435

  Fly   371 R-GCATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQ 434
            . |.|..:|..:|   :...|.:.|.|....|:|.|:||||.|.||:||:..|.:||...:|.|:
Human   436 NVGAAEKVFSYMD---RQPNLPSPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGE 497

  Fly   435 TVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQ 499
            ..||||.:|.||||...|||..|.|..|.||||:..|.:|...:|.|.:..||||||||.|::..
Human   498 VTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRN 562

  Fly   500 NISYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKI 564
            ||:||.......::.|||..|.|.:||..:.....:.:||:||||:.|||||:||||||:::|::
Human   563 NIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRV 627

  Fly   565 LLLDEATSALDYQSEKQVQQALDLASKG-RTTIVVSHRLSAIRGADKIVFIHDGKV-----LEEG 623
            |:|||||||||.|.|:.:|   |..|:| ||.:|::|||.|::.|.:|:.:.:||:     |:||
Human   628 LILDEATSALDVQCEQALQ---DWNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQKLAQLQEG 689

  Fly   624  623
            Human   690  689

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	175/520 (34%)
		MdlB	711..1299	CDD:440747
TAP2	NP_000535.3	3a01208	1..697	CDD:273363	175/520 (34%)
		Part of the peptide-binding site. /evidence=ECO:0000269|PubMed:8955196	301..389		31/98 (32%)
		Part of the peptide-binding site. /evidence=ECO:0000269|PubMed:8955196	414..433		3/20 (15%)