Protein Alignment Mdr65 and TAP1

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_000584.3
• Gene: TAP1 / 6890
• HGNCID: 43
• Length: 748
• Species: Homo sapiens
• Alignment Length: 614
• Identity: 195/614 - (31%)
• Similarity: 322/614 - (52%)
• Gaps: 72/614 - (11%)

  Fly    53 IMCCI----KALTLPAVVIIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEAL 113
            ::.|:    :.|:|..|:::.|....|               |:|.|.|  .||:...::.:...
Human   176 LLGCLGSETRRLSLFLVLVVLSSLGEM---------------AIPFFTG--RLTDWILQDGSADT 223

  Fly   114 YDDSISYGILLTIASVVMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFT 178
            :..:::...:|||||.|:...|   ..::|.......:.::.::|.:|:||:..:.......|..
Human   224 FTRNLTLMSILTIASAVLEFVG---DGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIM 285

  Fly   179 QSMVDDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQG 243
            ..:.:|...:.|.:||.:..|::.:|..:..:.|.......||:.....:||:.||...|.|:..
Human   286 SRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQ 350

  Fly   244 KLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQ----------WKG 298
            .|..:.:||.|.:..:|.|.||::.||.||..|:.|.|::...|...:..:|          |..
Human   351 LLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTT 415

  Fly   299 AFSGLSDAVLK-SMLY----LSCAGAFWYGVNLIIDDRNVENKEYTPAI-LMIAFFGIIVGADNI 357
            :.||:   :|| .:||    |..:||...| ||:  ...:...::|.|: ::::.:
Human   416 SISGM---LLKVGILYIGGQLVTSGAVSSG-NLV--TFVLYQMQFTQAVEVLLSIY--------- 465

  Fly   358 ARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIV 422
                |.::.   |.|.:..:|:.:|.|.:..|   .|.|....|.|.|:||||.|.||:||:|:|
Human   466 ----PRVQK---AVGSSEKIFEYLDRTPRCPP---SGLLTPLHLEGLVQFQDVSFAYPNRPDVLV 520

  Fly   423 HRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVG 487
            .:||...:|.|:..||||.:|.||||...|||..|.|..|.:|||...:.:|..::|...:|.||
Human   521 LQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVG 585

  Fly   488 QEPVLFLGTIAQNISYG---KPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQK 549
            |||.:|..::.:||:||   ||  |.:||.|||.::|||.||:.||:.|.:.:.|.||||||||:
Human   586 QEPQVFGRSLQENIAYGLTQKP--TMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQR 648

  Fly   550 QRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASK--GRTTIVVSHRLSAIRGADKIV 612
            |.:|:|||||:.|.:|:||:||||||..|:.||:|.|..:.:  .|:.::::..||.:..||.|:
Human   649 QAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHIL 713

  Fly   613 FIHDGKVLEEGSHDDLMALEGAYYNMVRA 641
            |:..|.:.|.|:|..||..:|.|:.||:|
Human   714 FLEGGAIREGGTHQQLMEKKGCYWAMVQA 742

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	182/543 (34%)
		MdlB	711..1299	CDD:440747
TAP1	NP_000584.3	3a01208	18..740	CDD:273363	192/610 (31%)
		Part of the peptide-binding site. /evidence=ECO:0000269|PubMed:8955196	375..420		11/44 (25%)
		Part of the peptide-binding site. /evidence=ECO:0000269|PubMed:8955196	453..487		8/49 (16%)