Protein Alignment Mdr65 and Abcb9

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_071574.1
• Gene: Abcb9 / 63886
• RGDID: 620254
• Length: 762
• Species: Rattus norvegicus
• Alignment Length: 632
• Identity: 203/632 - (32%)
• Similarity: 319/632 - (50%)
• Gaps: 93/632 - (14%)

  Fly   707 APPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALA------EKDP 765
            ||.|:.: ..|..::|...|.:..:|:     |.:...:..|....|..:|...|      :|..
  Rat   160 APAEQAS-GATLQKLLSYTKPDVAFLV-----AASFFLIVAALGETFLPYYTGRAIDSIVIQKSM 218

  Fly   766 EDALRRTAVLSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNS 830
            :.......|:   || ||..:.|...::..:|......|..|:|...|.::|:||..:||:  |.
  Rat   219 DQFTTAVVVV---CL-LAIGSSLAAGIRGGIFTLVFARLNIRLRNCLFRSLVSQETSFFDE--NR 277

  Fly   831 VGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMY-YNWKLALLCLANCPIIVGSVIL 894
            .|.|.:||:.:...:...:...::..::.... ::.|.|.|: .:|:|:|:.....|||:
  Rat   278 TGDLISRLTSDTTMVSDLVSQNINIFLRNTVK-VTGVVVFMFSLSWQLSLVTFMGFPIIM----- 336

  Fly   895 EAKMMSN-------AVVREKQ-VIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLI 951
               |:||       .:.:|.| .:..|...|.|:|:.::||          |.:..|.:..||.:
  Rat   337 ---MVSNIYGKYYKRLSKEVQSALARASTTAEETISAMKTV----------RSFANEEEEAEVFL 388

  Fly   952 RQKLRWRGVLNSTMQASAFFAY------------AVALCYGGVLVSEGQLPFQDIIKVSETLLYG 1004
            | ||:....|| ..:|:|:.:|            ...|.|||.||..||:...::|..   ::|
  Rat   389 R-KLQQVYKLN-RKEAAAYMSYVWGSGLTLLVVQVSILYYGGHLVISGQMSSGNLIAF---IIY- 447

  Fly  1005 SMMLAQSLAFTPAFSAALIAG----HRLFQILDRKPKIQSPMGTIKNTLAKQLNL----FEG-VR 1060
            ..:|...:....:..:.|:.|    .::|:.:||:|           |:.....|    .|| |.
  Rat   448 EFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQP-----------TMVHDGRLAPDHLEGRVD 501

  Fly  1061 YRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDI 1125
            :..:.|.|.|||..::|..:...:..|:..||||.||.|||:||.:|:.:|....|.:.:|.:.|
  Rat   502 FENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLQGGRVLLDGEPI 566

  Fly  1126 ---QHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLP 1187
               .|..    :...:.:|||||.||.|||.:||:||  ..:|....::.||:.||||.||:.|.
  Rat   567 GAYDHKY----LHRVISLVSQEPVLFARSITDNISYG--LPTVPFEMVVEAAQKANAHGFIMELQ 625

  Fly  1188 NGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTC 1252
            :||.|..|.:|.|||||||||:|:||||||||.:|:|||||||||.:||.|:|||:.......|.
  Rat   626 DGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQRHTV 690

  Fly  1253 IVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQGGIYAKLHKTQ 1299
            ::||||||||:.|.:|.|:..|:||:||.|.||::|||:||||.:.|
  Rat   691 LIIAHRLSTVERAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQ 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747
		MdlB	711..1299	CDD:440747	199/626 (32%)
Abcb9	NP_071574.1	3a01208	44..734	CDD:273363	201/627 (32%)