Protein Alignment Mdr65 and abcb9

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_001119906.1
• Gene: abcb9 / 570148
• ZFINID: ZDB-GENE-050517-12
• Length: 789
• Species: Danio rerio
• Alignment Length: 732
• Identity: 228/732 - (31%)
• Similarity: 350/732 - (47%)
• Gaps: 131/732 - (17%)

  Fly    32 AFLKLFRFSTYGEI---GWLFFGFIMCCIKALTLPAVVIIY---------------SEFTSMLVD 78
            |..||...|..|.:   .|....|...|:.|:   .|:|.:               ||.|..|||
Zfish    97 ALAKLLMLSEEGNLMYDPWFLSLFSWTCVAAI---GVMIFWKILSQTPNAVSDREDSEDTERLVD 158

  Fly    79 -------RAMQFGTSSNVHA----------------------------------LPLFGGGKTLT 102
                   ::|:.| ..:.|:                                  :|.: .|:.:.
Zfish   159 ETEDESEKSMKSG-KEHTHSGATIGRLLSYCKKDSSLLSIAFFFLLLSAVCEAFIPYY-TGQAID 221

  Fly   103 NASREENNEALYDDSISYGILLTIASVVM-FISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDI 166
            ....:::.:......|:..:|..::|:.: |..|:|||     ...|...|:|..||.|::.|:|
Zfish   222 GIVIQKSMDHFAKPMITLSVLALVSSIAIGFRGGVFSV-----TFARLNIRLRNLLFRSLMHQEI 281

  Fly   167 GWHDLASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLV 231
            |:.|.....:.|..:..|..::.|.||:.|..|:...|..:......|...|||::......|.:
Zfish   282 GFFDANHTGDITSRLTSDTTQVSDLISQNVNLFLRSFVKAVGIFIFMFGMSWKLSVVTIMGFPYI 346

  Fly   232 ILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRY-----ENFLVPAR 291
            .:::....::..|||...|.:.|.|..:|||.:|::|||.||..|..|...|     |.|::..:
Zfish   347 AVVSKLYGEYYKKLTKEVQTALAQANKVAEETISAMRTVRSFANEDQEGDMYYSRLQEMFVLNKK 411

  Fly   292 KA-----SQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGII 351
            :|     ..|....|.|  |:..::|:        ||.:|:     |.|:.....::....:.:.
Zfish   412 QAIAYACFMWSSYISEL--ALQVAILF--------YGGHLV-----VTNQMSGGTLISFVIYELE 461

  Fly   352 VGADNIARTAPFLESFATAR-------GCATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQD 409
            :|        ..|||.::..       |.|..:|:.||...|   .:.:|:.....|.|.|||.:
Zfish   462 LG--------EALESISSVYTGLMQGVGAAEKVFEYIDRKPK---HALNGQEAPETLEGQVEFNN 515

  Fly   410 VFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKY 474
            |.|.||||||:.|.:.::..:|.||..||||.||.|||:||.||:.||.|..|.||:|...:..|
Zfish   516 VTFAYPSRPEMDVLKNVSFSLRPGQVTALVGPSGGGKSSCVCLLENFYAPQQGQVLVDGRPVNTY 580

  Fly   475 NIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGE 539
            ..::..|.:|:|.||||||..|:..|||||.|.|..:.:..||..|.||:|||.|.:.|.|.:||
Zfish   581 QHKYYHSKVALVAQEPVLFARTVQMNISYGVPEAPMEAVIRAAINANAHDFITGLSKGYDSGVGE 645

  Fly   540 RGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSA 604
            :|:|||||||||:|||||||::|:||:|||||||||.:||..|||||:...:..|.:|::||||.
Zfish   646 KGTQLSGGQKQRVAIARALIRSPRILILDEATSALDSESEYIVQQALNNLMREHTVLVIAHRLST 710

  Fly   605 IRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVR----AGDINMPD---------EVEKEDSI 656
            :..||.|:.|..|.|:|:|.|.:|||..|.|..:|:    ..:|::.|         |::.||
Zfish   711 VERADNILVIDKGSVVEQGPHAELMARGGLYCKLVQRQILGTEIDVDDKNPSPAPTWELKTED-- 773

  Fly   657 EDTKQKSLALFEKSFET 673
               |:.:....:..:||
Zfish   774 ---KENAEDCSDTEYET 787

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	198/544 (36%)
		MdlB	711..1299	CDD:440747
abcb9	NP_001119906.1	3a01208	46..745	CDD:273363	219/683 (32%)