Protein Alignment Mdr65 and Abcb9

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_063928.2
• Gene: Abcb9 / 56325
• MGIID: 1861729
• Length: 762
• Species: Mus musculus
• Alignment Length: 632
• Identity: 203/632 - (32%)
• Similarity: 319/632 - (50%)
• Gaps: 93/632 - (14%)

  Fly   707 APPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALA------EKDP 765
            ||.|:.: ..|..::|...|.:..:|:     |.:...:..|....|..:|...|      :|..
Mouse   160 APAEQAS-GATLQKLLSYTKPDVAFLV-----AASFFLIVAALGETFLPYYTGRAIDSIVIQKSM 218

  Fly   766 EDALRRTAVLSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNS 830
            :.......|:   || ||..:.|...::..:|......|..|:|...|.::|:||..:||:  |.
Mouse   219 DQFTTAVVVV---CL-LAIGSSLAAGIRGGIFTLVFARLNIRLRNCLFRSLVSQETSFFDE--NR 277

  Fly   831 VGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMY-YNWKLALLCLANCPIIVGSVIL 894
            .|.|.:||:.:...:...:...::..::.... ::.|.|.|: .:|:|:|:.....|||:
Mouse   278 TGDLISRLTSDTTMVSDLVSQNINIFLRNTVK-VTGVVVFMFSLSWQLSLVTFMGFPIIM----- 336

  Fly   895 EAKMMSN-------AVVREKQ-VIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLI 951
               |:||       .:.:|.| .:..|...|.|:|:.::||          |.:..|.:..||.:
Mouse   337 ---MVSNIYGKYYKRLSKEVQSALARASTTAEETISAMKTV----------RSFANEEEEAEVFL 388

  Fly   952 RQKLRWRGVLNSTMQASAFFAY------------AVALCYGGVLVSEGQLPFQDIIKVSETLLYG 1004
            | ||:....|| ..:|:|:.:|            ...|.|||.||..||:...::|..   ::|
Mouse   389 R-KLQQVYKLN-RKEAAAYMSYVWGSGLTLLVVQVSILYYGGHLVISGQMSSGNLIAF---IIY- 447

  Fly  1005 SMMLAQSLAFTPAFSAALIAG----HRLFQILDRKPKIQSPMGTIKNTLAKQLNL----FEG-VR 1060
            ..:|...:....:..:.|:.|    .::|:.:||:|           |:....:|    .|| |.
Mouse   448 EFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQP-----------TMVHDGSLAPDHLEGRVD 501

  Fly  1061 YRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDI 1125
            :..:.|.|.|||..::|..:...:..|:..||||.||.|||:||.:|:.:|....|.:.:|...|
Mouse   502 FENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLQGGRVLLDGKPI 566

  Fly  1126 ---QHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLP 1187
               .|..    :...:.:|||||.||.|||.:||:||  ..:|....::.||:.||||.||:.|.
Mouse   567 GAYDHKY----LHRVISLVSQEPVLFARSITDNISYG--LPTVPFEMVVEAAQKANAHGFIMELQ 625

  Fly  1188 NGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTC 1252
            :||.|..|.:|.|||||||||:|:||||||||.:|:|||||||||.:||.|:|||:.......|.
Mouse   626 DGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQRHTV 690

  Fly  1253 IVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQGGIYAKLHKTQ 1299
            ::||||||||:.|.:|.|:..|:||:||.|.||::|||:||||.:.|
Mouse   691 LIIAHRLSTVERAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQ 737

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747
		MdlB	711..1299	CDD:440747	199/626 (32%)
Abcb9	NP_063928.2	3a01208	44..734	CDD:273363	201/627 (32%)