Protein Alignment Mdr65 and Abcb10

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_062425.1
• Gene: Abcb10 / 56199
• MGIID: 1860508
• Length: 715
• Species: Mus musculus
• Alignment Length: 607
• Identity: 210/607 - (34%)
• Similarity: 326/607 - (53%)
• Gaps: 59/607 - (9%)

  Fly   720 RILQLAKQEWCYLILGTISAVAVGFLYPAFAV----------IFGEFYAALAEKDPEDALRRTAV 774
            ::|.|.:.|     .|.:|| |||||..:..:          |....|...:|...:...|..||
Mouse   124 KLLGLVRPE-----RGRLSA-AVGFLAVSSVITMSAPFFLGRIIDVIYTNPSEGYGDSLTRLCAV 182

  Fly   775 LSWACLGLAFLTGLVC-FLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARL 838
            |:  |:   ||.|... .::.||...:|..:..|:|...|::::.|||.:||  ....|.|..||
Mouse   183 LT--CV---FLCGAAANGIRVYLMQSSGQSIVNRLRTSLFSSILRQEVAFFD--KTRTGELINRL 240

  Fly   839 SGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAV 903
            |.:...:..::...||..::|.:.....|.:..:.:..||...|:..|.|....::..:.:....
Mouse   241 SSDTALLGRSVTENLSDGLRAGAQASVGVGMMFFVSPSLATFVLSVVPPISVLAVIYGRYLRKLS 305

  Fly   904 VREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQAS 968
            ...:..:.||.::|.|.|.||||:....:|...:.:||..:.::..|.:::         .:..:
Mouse   306 KATQDSLAEATQLAEERIGNIRTIRAFGKEMTEVEKYTGRVDQLLQLAQKE---------ALARA 361

  Fly   969 AFFAYA--------VALCY-GGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALI- 1023
            .||..|        :::.| ||:|:....:   .:.::|..|:| :..:..|:....:|.:.|:
Mouse   362 GFFGAAGLSGNLIVLSVLYKGGLLMGSAHM---TVGELSSFLMY-AFWVGLSIGGLSSFYSELMK 422

  Fly  1024 ---AGHRLFQILDRKPKIQSPMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLDLEV 1084
               ||.||:::|:|:|::....|.:.:.     ..|:| :.:|.:.|.||.||:..:.....|.:
Mouse   423 GLGAGGRLWELLERQPRLPFNEGMVLDE-----KTFQGALEFRNVHFTYPARPEVSVFQDFSLSI 482

  Fly  1085 LKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFE 1149
            ..|...||||.||.||||.|.||.|.|||:.||:.:|..||: .|....:|:|:|.|||||.||.
Mouse   483 PSGSVTALVGPSGSGKSTVVSLLLRLYDPNSGTVSLDGHDIR-QLNPVWLRSKIGTVSQEPVLFS 546

  Fly  1150 RSIAENIAYG-DNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIAR 1213
            .|:||||||| ||..||:..::..||:.|||..||.|.|.|:||.:|.:|..|||||||||||||
Mouse   547 CSVAENIAYGADNLSSVTAQQVERAAEVANAAEFIRSFPQGFDTVVGEKGILLSGGQKQRIAIAR 611

  Fly  1214 ALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVE 1278
            ||::|||||||||||||||.::|.|||:|||....|||.::|||||||::||:.:.|:.:|::.|
Mouse   612 ALLKNPKILLLDEATSALDAENEHLVQEALDRLMEGRTVLIIAHRLSTIKNANFVAVLDHGKICE 676

  Fly  1279 QGNHMQ-LISQGGIYAKLHKTQ 1299
            .|.|.: |:...|:|.||...|
Mouse   677 HGTHEELLLKPNGLYRKLMNKQ 698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747
		MdlB	711..1299	CDD:440747	209/605 (35%)
Abcb10	NP_062425.1	MdlB	115..699	CDD:440747	210/607 (35%)