Protein Alignment Mdr65 and abcb8

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_001017544.1
• Gene: abcb8 / 548340
• ZFINID: ZDB-GENE-050410-6
• Length: 714
• Species: Danio rerio
• Alignment Length: 602
• Identity: 209/602 - (34%)
• Similarity: 321/602 - (53%)
• Gaps: 64/602 - (10%)

  Fly   731 YLILGTI----SAVAVGFLYPAFAVIFGEFYAALAEKDPEDA---LRRTAVLSWACLGLAFLTGL 788
            :.::|.|    .|.|:....|   ::.|:....:|....|.|   :|.....:...|||..|.||
Zfish   144 FALMGAILLAFGAAALNIQIP---LMLGDLVNVVARHMREQAGHYMRDIQAPAVKLLGLYALQGL 205

  Fly   789 VCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPL 853
            :......|.:..|..:...||...|.:::.|::.:||  .|..|.|..||:.:..:.:.:....:
Zfish   206 LTSGYIILLSRVGERVAADMRTTLFTSLLRQDIAFFD--ANKTGQLVNRLTSDIQEFKSSFKLVI 268

  Fly   854 SGMIQALSNFISSVS--VAMYY-NWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACR 915
            |   |.|.:...:|.  |::|: :.||..|.:...|.:||:..|....:.....:.::.:.:|..
Zfish   269 S---QGLRSATQTVGCFVSLYFISPKLTGLTVVVLPCLVGAGALIGSFLRKLSRKAQEQVAKATG 330

  Fly   916 IATESITNIRTVAGLRREADVIREYTEEIQRV----EVLIRQKLRWRGVLNSTMQA---SAFFAY 973
            :|.|::.|:|||.....|...:..|..|:|:.    |.|......::|:.|..:..   ...||
Zfish   331 VADEALGNVRTVRAFAMEDRELEMYAAEVQKSAAMNETLGTGIAVFQGLSNIVLNCIVLGTIFA- 394

  Fly   974 AVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALI----AGHRLFQILDR 1034
                  ||.|::...|...|::    :.|..|..:.:|||........::    ||.|:|:.|..
Zfish   395 ------GGSLMARDDLSPGDLM----SFLVASQTVQRSLASISILFGQMVRGMSAGARVFEYLAL 449

  Fly  1035 KPKI------QSPMGTIKNTLAKQLNLFEGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALV 1093
            .|.:      :.|:.          :|...|.:..|.|.|||||..:||....|.:...:|||:|
Zfish   450 DPSVPLTGGGRIPLD----------SLMGRVDFMNISFSYPTRPGNQILKHFSLTLPPCKTVAIV 504

  Fly  1094 GHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTK---LGIVSQEPTLFERSIAEN 1155
            |.||.||||...||:|:|||..|.:.:|..||:   |||....:   :|.:||||.||..|:.||
Zfish   505 GESGGGKSTVAALLERFYDPSSGVVMLDGLDIR---TLDPSWLRGHVIGFISQEPVLFGTSVMEN 566

  Fly  1156 IAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPK 1220
            |.:|  :.|.:..|:::|||.||||:||....:||:|.:|.||..||||||||||||||||:||.
Zfish   567 IRFG--KPSATDAEVVSAAKQANAHNFITGFADGYNTVVGERGVTLSGGQKQRIAIARALVKNPS 629

  Fly  1221 ILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQL 1285
            ||:|||||||||.:||::||:|||.|.:|||.::|||||||:|.||:|||:.||::||.|.|::|
Zfish   630 ILILDEATSALDAESERVVQEALDRATTGRTVLIIAHRLSTIQAADLICVMSNGRIVEAGTHLEL 694

  Fly  1286 ISQGGIYAKLHKTQKDH 1302
            :|:||:||:|.|.|:.:
Zfish   695 LSKGGLYAELIKRQRSN 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747
		MdlB	711..1299	CDD:440747	208/597 (35%)
abcb8	NP_001017544.1	MdlB	131..708	CDD:440747	208/597 (35%)