Protein Alignment Mdr65 and abcb5

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: XP_031759158.1
• Gene: abcb5 / 394865
• XenbaseID: XB-GENE-5950198
• Length: 1317
• Species: Xenopus tropicalis
• Alignment Length: 1300
• Identity: 523/1300 - (40%)
• Similarity: 765/1300 - (58%)
• Gaps: 72/1300 - (5%)

  Fly     7 STSSSEGKSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSE 71
            :|..:|...||:.           |..:.:|:|:.:.:|..:..|.:.........|.:.:::.|
 Frog    80 TTKENEKNKQEQI-----------IGPISIFQFADWLDIFLMIIGTLGAIGCGSCYPLMNVVFGE 133

  Fly    72 FT-SMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVMFISG 135
            .: |.|...:....:|:.....|:          ..|....:||...:.:.:|         ..|
 Frog   134 MSDSFLCHNSSLQNSSACAKFKPI----------EEEIQKFSLYYAGLGFAVL---------FCG 179

  Fly   136 IFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKVGHFV 200
            ...|..:.:.|.||..:||...|.||:.|:|||.|:....:....:.:::.||.|||.:||.||.
 Frog   180 YLQVSCWVVAASRQTRKMRKAFFHSVLSQEIGWFDVTKSGDLNTRLTENINKINDGIGDKVAHFF 244

  Fly   201 YLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILS 265
            ......:..:.|....||||.|.:.:..|::.|.:...::....||.:|..:||.||.:|:|:||
 Frog   245 QNTTICVSGILIGLIQGWKLALVILATSPVLTLASAMFSRIVVSLTTKELAAYAKAGAVAQEVLS 309

  Fly   266 SIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDD 330
            ||||||:||||:.|::||...|..|:.....|...|..:..::....|.:....||||..|:::|
 Frog   310 SIRTVVAFGGEEKEIKRYTENLKQAKDIGIKKSIASQFALGLVNGAFYATYGVGFWYGTTLVLED 374

  Fly   331 RNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPLSTDG- 394
                 .:||...:|..||.:...:..|.:.|...|:|..||..|:::||||..:|.||..|.||
 Frog   375 -----DDYTIGDVMAVFFNVSFSSYAIGQAASHFEAFHIARAAASSIFKVIKQSSSIDNFSNDGF 434

  Fly   395 KLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDP 459
            |..|  ::|::|.:|::|.|||||.|.|..|||:.:::||||||||.|||||||.||||||.|||
 Frog   435 KPDN--IKGNIELKDIYFSYPSRPGVKVLNGLNLSVKSGQTVALVGQSGCGKSTIVQLLQRLYDP 497

  Fly   460 VFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHE 524
            ..|::.:|..||:..|:.:.|..|.||.||||||..||.|||.||:...|.:|||.|..:|.|::
 Frog   498 KEGTLAVDGHDIKSLNVTYYRELIGVVSQEPVLFGTTIKQNIRYGRDDVTDEEIEKAVKEANAYD 562

  Fly   525 FITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLA 589
            ||..||:.|.:::||||:|||||||||||:||||::|||||||||||||||..||..||.|||.|
 Frog   563 FIMALPDKYETLVGERGAQLSGGQKQRIAVARALVRNPKILLLDEATSALDTGSEAVVQAALDKA 627

  Fly   590 SKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVRAGDINMPDEVEKED 654
            .||||||||:||||.|..||.||.|.:|.|.|:|:|.:||..:|.|:::..|..:.:.|:.|..:
 Frog   628 RKGRTTIVVAHRLSTIWTADVIVVIDNGAVAEQGTHSELMEKKGIYFSLATAQTVQLSDDNETTE 692

  Fly   655 SIEDTKQKSLALFEKSFETSPLNFEKGQKNSVQFEEPIIKALIKDTNAQSAEAPPEKPNFFRTFS 719
                 |.::..::||:......|.:...|:.:..:|.           :..|:..:.|..  :|.
 Frog   693 -----KNQNGIIYEKASLIQRFNSQTSLKSKILEDED-----------EEEESKKDLPTV--SFF 739

  Fly   720 RILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRRTAVLSWACLGLAF 784
            ::|:|.:.||.|::||.|:|..:|.|.|.|.:.:....|..|..||| .:|:.:.|   |..:..
 Frog   740 QLLKLNRSEWPYILLGIIAAGVIGSLLPLFCIFYARIIAVFASNDPE-TIRKESDL---CSLIFG 800

  Fly   785 LTGLVCFL----QTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDI 845
            |||:|..|    :.|:|..:|..||.|:|.|.|.||:.|::.||||::|:.|||:.||:.:|.:|
 Frog   801 LTGVVILLAYIARGYMFGRSGETLTMRLRHMAFKAMIQQDIAWFDDKDNNTGALTTRLATDASEI 865

  Fly   846 QGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVI 910
            |.|.||.|..:.:.|...:.:|.:|..|.|:||||.||..|.:|...:||...::....|:|:.:
 Frog   866 QTATGYRLGFLAENLIGIVLTVIIAFVYGWELALLGLAMAPFMVICGLLEFSALTGFATRDKKQL 930

  Fly   911 EEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAYAV 975
            :.|.:||||::.||||:..|.||......|:|.:|:......:|.:..|:..:...|..:|.:|.
 Frog   931 QRAGKIATEAVDNIRTLVSLTRERTFEEMYSESLQKPYRNSLRKAQIYGLYFAIGHAFYYFTHAA 995

  Fly   976 ALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKIQS 1040
            ..|:|..|:...::..::.:.|...:.:|:|.|..:|.|.|.::.|..|...||.:.:.||.|.|
 Frog   996 LFCFGAYLIKYERINVEEALLVFSVITFGAMTLGTTLTFAPDYAKATSAARYLFALFESKPAIDS 1060

  Fly  1041 PMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCV 1104
                 .:...::.:.|.| :.:|.:.|.||||.|.::|..|.::|..|||||.||.|||||||.|
 Frog  1061 -----SSQQGQKPDCFSGSLEFRNVSFNYPTRSDVRVLRDLCVKVESGQTVAFVGSSGCGKSTSV 1120

  Fly  1105 QLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVE 1169
            |||||:|||.||.:.:|..|.: ...:..:|:::|||||||.||:.|||||||||||.|:|||.|
 Frog  1121 QLLQRFYDPKEGEVLLDDVDAK-CFNVQWLRSQMGIVSQEPVLFDCSIAENIAYGDNSRTVSMDE 1184

  Fly  1170 IIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQ 1234
            |.:|||:||.||||..||..|:|.:||:||||||||||||||||||:|.||||||||||||||.:
 Frog  1185 IQSAAKAANIHSFIEGLPLKYETLVGAKGTQLSGGQKQRIAIARALIRAPKILLLDEATSALDNE 1249

  Fly  1235 SEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQGGIYAKLHKTQ 1299
            ||::||||||.|..|||||:|||||:||||||:|.|:..|:::|.|:|.:|:::.|.|..|...|
 Frog  1250 SEKVVQQALDQARKGRTCILIAHRLTTVQNADIIVVMNKGKIIEHGSHQELLAKCGAYYDLVNAQ 1314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	233/523 (45%)
		MdlB	711..1299	CDD:440747	261/592 (44%)
abcb5	XP_031759158.1	PTZ00265	164..1311	CDD:240339	505/1190 (42%)