Protein Alignment Mdr65 and Mdr50

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Alignment Length: 1327
• Identity: 540/1327 - (40%)
• Similarity: 780/1327 - (58%)
• Gaps: 95/1327 - (7%)

  Fly     2 ERDEVSTSSSEGKSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVV 66
            :.||...|..|..||..       |..:.:::.:|||::|..:......|.:......||.||..
  Fly    49 KHDESDASDEEDGSQYH-------EDVKQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANS 106

  Fly    67 IIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSIS---------YGI 122
            :|:....:.::|                .||       ..|.......||:||         :.:
  Fly   107 LIFGNLANDMID----------------LGG-------LLESGKSYRADDAISTLLLDKVRQFSL 148

  Fly   123 LLTIASVVMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEK 187
            ..|...::|.:....|:..||..|..|:..:|.|.|.|::.||:.|:|..........|.:|:.|
  Fly   149 QNTYIGIIMLVCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSK 213

  Fly   188 IRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQES 252
            :.||::|||..||:.:|.|:.::.::|..||:|:|...:.:||..:....||....:|..:|...
  Fly   214 MEDGLAEKVVMFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTM 278

  Fly   253 YAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCA 317
            ||||..:||..||.||||.:|.||..||..|:..:|.|:..:..:..|||:...:|...:|.|.|
  Fly   279 YAGAAVVAEGALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYA 343

  Fly   318 GAFWYGVNLII---DDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFK 379
            .||||||.|:|   .:...||  |....::..||.:::|:.||...||::|:|..|:|....:|.
  Fly   344 LAFWYGVGLVIKGYHEPAYEN--YDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFH 406

  Fly   380 VIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGC 444
            :|:...:|:|:..:||.||..|. .:||::|.|:||:||||.:...||::|..||||||||.|||
  Fly   407 IIEQIPEINPIDGEGKKLNEPLT-TIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGC 470

  Fly   445 GKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGAT 509
            |||||:||:||||||..|::|.:..:::..:|.||||.|.||||||:||..:|.:||.||:..||
  Fly   471 GKSTCIQLVQRFYDPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDAT 535

  Fly   510 QKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSAL 574
            ::||||||..|.|..||..||:.|.:::||||:|||||||||||||||||::|:|||||||||||
  Fly   536 REEIEAAAAAANAAIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSAL 600

  Fly   575 DYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMV 639
            |..||.:||.||:..|.|||||:|:||||.:|.||:||.|:.|:|:|.|:|.:||.|:..|:|:|
  Fly   601 DTASEAKVQAALEKVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLV 665

  Fly   640 R-------------AGDINMPDEVEKEDSIEDTKQKSLALFEKSFETSPLNFEKGQKNSVQFEEP 691
            .             .|||....:::.||. |:.|    .|.|...|...:..||.:|..
  Fly   666 TTQLGEDDGSVLSPTGDIYKNFDIKDEDE-EEIK----VLSEDEDEDVMVTDEKNKKKK------ 719

  Fly   692 IIKALIKDTNAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEF 756
              |..:||            ||..:....::::.|.||..:.:|.||:|.:|...|.|||:||..
  Fly   720 --KKKVKD------------PNEVKPMLEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSI 770

  Fly   757 YAALAEKDPEDALRRTA---VLSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVN 818
            ...|:.||.:..:|..:   .|.:...|:  :.|:..|||.|.|..||..||.|:|.:.|.||:.
  Fly   771 LQILSVKDNDQYVRENSNQYSLYFLIAGI--VVGIATFLQIYFFGIAGERLTERLRGLMFEAMLR 833

  Fly   819 QEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLA 883
            |||.||||:.|..|:|.|||||:|..:|||.|..:..::|::|.....::::|||.|.|.|:.||
  Fly   834 QEVAWFDDKANGTGSLCARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALA 898

  Fly   884 NCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVE 948
            ..|.|:.:..::..:|:...:...:.:|...::|.|.::||||||.|.||....:.|...:....
  Fly   899 FTPFILIAFYMQRTLMAKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAV 963

  Fly   949 VLIRQKLRWRGVLNSTMQASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLA 1013
            .:.::...:||::....::..|||||..:.||...|....:.|.|:.|||:.|:.|:..:|.:||
  Fly   964 EISKRNTHFRGLVYGLARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGTASIANALA 1028

  Fly  1014 FTPAFSAALIAGHRLFQILDRKPKIQSPMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKIL 1077
            |.|.....:.|...:|..|.|:|.|....|..::....     || ||:..::|.||||.:.::|
  Fly  1029 FAPNMQKGVSAAKTIFTFLRRQPSIVDRPGVSRDPWHS-----EGYVRFDKVKFSYPTRSEIQVL 1088

  Fly  1078 NGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVS 1142
            .||:|.|.|||.:||||.||||||||:||:||:||.|||...||..|:: ::::..:|.:|||||
  Fly  1089 KGLELAVSKGQKIALVGPSGCGKSTCIQLIQRFYDVDEGATLIDECDVR-NVSMTNLRNQLGIVS 1152

  Fly  1143 QEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQ 1207
            |||.||:|:|.|||:||||.|:|:..|||:|.|.:|.|.||.:||.|||||||.:|.||||||||
  Fly  1153 QEPILFDRTIRENISYGDNARNVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQ 1217

  Fly  1208 RIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQ 1272
            ||||||||:|||||:||||||||||.:||::||.|||.|..|||.|.||||||||.::|||.|.:
  Fly  1218 RIAIARALIRNPKIMLLDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFE 1282

  Fly  1273 NGQVVEQGNHMQLISQGGIYAKLHKTQ 1299
            ||.|.|.|:|.||::..|:|..|:|.|
  Fly  1283 NGLVCEAGDHKQLLANRGLYYTLYKLQ 1309

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	239/547 (44%)
		MdlB	711..1299	CDD:440747	261/591 (44%)
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	531/1297 (41%)