Protein Alignment Mdr65 and ABCB5

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_001157413.1
• Gene: ABCB5 / 340273
• HGNCID: 46
• Length: 1257
• Species: Homo sapiens
• Alignment Length: 1327
• Identity: 521/1327 - (39%)
• Similarity: 759/1327 - (57%)
• Gaps: 101/1327 - (7%)

  Fly     1 MERDEVSTSSSE-----GKSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKAL 60
            ||..|.:....|     |.::|:..:.:     |.:..:::|||:...:|..:..|.:...:...
Human     1 MENSERAEEMQENYQRNGTAEEQPKLRK-----EAVGSIEIFRFADGLDITLMILGILASLVNGA 60

  Fly    61 TLPAVVIIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREEN----NEALYDDSISYG 121
            .||.:.::..|.:..|:                  .|....||.:..:|    .|.|.:|.
Human    61 CLPLMPLVLGEMSDNLI------------------SGCLVQTNTTNYQNCTQSQEKLNEDM---- 103

  Fly   122 ILLTI----ASVVMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMV 182
            .|||:    ..|...|.|...:.::.:.|.||..|:|.:.|.||:.|||||.|..........|.
Human   104 TLLTLYYVGIGVAALIFGYIQISLWIITAARQTKRIRKQFFHSVLAQDIGWFDSCDIGELNTRMT 168

  Fly   183 DDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTA 247
            ||::||.|||.:|:......:..|.|.:|:....||||||...|..||::......::....||:
Human   169 DDIDKISDGIGDKIALLFQNMSTFSIGLAVGLVKGWKLTLVTLSTSPLIMASAAACSRMVISLTS 233

  Fly   248 REQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSML 312
            :|..:|:.||.:|||:|||||||::|..::.|:|||...|..|:..    |....::..|....:
Human   234 KELSAYSKAGAVAEEVLSSIRTVIAFRAQEKELQRYTQNLKDAKDF----GIKRTIASKVSLGAV 294

  Fly   313 YLSCAG----AFWYGVNLIIDDRNVENKE--YTPAILMIAFFGIIVGADNIARTAPFLESFATAR 371
            |....|    |||||.:||:      |.|  ||...::..||.:|..:..|....|..|:||.||
Human   295 YFFMNGTYGLAFWYGTSLIL------NGEPGYTIGTVLAVFFSVIHSSYCIGAAVPHFETFAIAR 353

  Fly   372 GCATNLFKVIDLTSKIDPLSTDGKLLNY---GLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAG 433
            |.|.::|:|||....||..||.|    |   .:.|.|||::|.|.|||||.:.:.:|||:||::|
Human   354 GAAFHIFQVIDKKPSIDNFSTAG----YKPESIEGTVEFKNVSFNYPSRPSIKILKGLNLRIKSG 414

  Fly   434 QTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIA 498
            :||||||.:|.||||.||||||.|||..|.:::|:.|||..|::..|.:|.||.||||||..||:
Human   415 ETVALVGLNGSGKSTVVQLLQRLYDPDDGFIMVDENDIRALNVRHYRDHIGVVSQEPVLFGTTIS 479

  Fly   499 QNISYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPK 563
            .||.||:...|.:|:|.||.:|.|::||...|..:.:::||:|:|:||||||||||||||::|||
Human   480 NNIKYGRDDVTDEEMERAAREANAYDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPK 544

  Fly   564 ILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDL 628
            ||:|||||||||.:|:..||.||:.||||||||||:||||.||.||.||.:.||.:.|:|:|.:|
Human   545 ILILDEATSALDSESKSAVQAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAEL 609

  Fly   629 MALEGAYYNMVRAGDINMPDEVEKEDSIEDTKQKSLALFEKSFETSPLNFEKGQKNSVQFEEPII 693
            ||..|.||::|.:.||...|| :.|.....|::|:.:|        ||:..|..|:..     |.
Human   610 MAKRGLYYSLVMSQDIKKADE-QMESMTYSTERKTNSL--------PLHSVKSIKSDF-----ID 660

  Fly   694 KALIKDTNAQSAE-APPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFY 757
            ||   :.:.||.| :.||.     :..:||:|.|.||.:::|||:::|..|.::|.|::||.:..
Human   661 KA---EESTQSKEISLPEV-----SLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIFAKII 717

  Fly   758 AALAEKDPEDALRRTAVLSWACLGLAFLTGLVC----FLQTYLFNYAGIWLTTRMRAMTFNAMVN 818
            ......|.........:.|.    :..:.|::|    |:|...:..||..||.|:|.:.|.||:.
Human   718 TMFGNNDKTTLKHDAEIYSM----IFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLY 778

  Fly   819 QEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLA 883
            |::.|||::.||.|.|:..|:.:...||||.|..:..:.|..:|...||.::..|.|::..|.|:
Human   779 QDIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILS 843

  Fly   884 NCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVE 948
            ..|::..:.::|...|:....::||.::.|.:||||::.||||:..|.||....:.|.|.:|...
Human   844 IAPVLAVTGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQH 908

  Fly   949 VLIRQKLRWRGVLNSTMQASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLA 1013
            ....:|.:..|...:...|..:||||....:|..|:..|::..:.:..|...:.||:|.:.::|.
Human   909 RNTSKKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLV 973

  Fly  1014 FTPAFSAALIAGHRLFQILDRKPKIQSPMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKIL 1077
            ..|.:|.|......||.:|::||.|.|     ::...|:.:..|| :.:|.:.|.||.|||..||
Human   974 LAPEYSKAKSGAAHLFALLEKKPNIDS-----RSQEGKKPDTCEGNLEFREVSFFYPCRPDVFIL 1033

  Fly  1078 NGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVS 1142
            .||.|.:.:|:|||.||.|||||||.||||||.|||.:|.:..|..|.: :|.:..:|:::.||.
Human  1034 RGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAK-ELNVQWLRSQIAIVP 1097

  Fly  1143 QEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQ 1207
            |||.||..|||||||||||.|.|.:.||..||.:||.||||..||..|:|::|.:|.||||||||
Human  1098 QEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQ 1162

  Fly  1208 RIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQ 1272
            |:||||||::.||||||||||||||..||::||.|||.|.:||||:|:.||||.:||||:|.|:.
Human  1163 RLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLH 1227

  Fly  1273 NGQVVEQGNHMQLISQGGIYAKLHKTQ 1299
            ||::.|||.|.:|:....||.||...|
Human  1228 NGKIKEQGTHQELLRNRDIYFKLVNAQ 1254

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	239/535 (45%)
		MdlB	711..1299	CDD:440747	238/592 (40%)
ABCB5	NP_001157413.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24		6/22 (27%)
		PTZ00265	8..1251	CDD:240339	516/1315 (39%)