Protein Alignment Mdr65 and hmt1

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_588371.3
• Gene: hmt1 / 3361134
• PomBaseID: SPCC737.09C
• Length: 830
• Species: Schizosaccharomyces pombe
• Alignment Length: 681
• Identity: 203/681 - (29%)
• Similarity: 338/681 - (49%)
• Gaps: 111/681 - (16%)

  Fly   675 PLNFEKGQ--------KNSVQFEEPIIKALI--KDTNAQSAEAPPEKPN------FFRTFSRIL- 722
            ||:||:.|        :|::......::..:  ..:|..:.::..:||:      :||:||.:|
pombe   187 PLDFEERQLTEESNVNENAISQNPSTVQLGVSASTSNFGTLKSTSKKPSDKSWAEYFRSFSTLLP 251

  Fly   723 --------QLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRRTAVLSWAC 779
                    :|..|.:..::|..:.. ||..|.|....:..|.....:||.|           |:.
pombe   252 YLWPTKDYRLQFQIFICIVLLFLGR-AVNILAPRQLGVLTEKLTKHSEKIP-----------WSD 304

  Fly   780 LGL----AFLTG-------LVCFLQTYLFNYAGIWLTTR----MRAMTFNAMVNQEVGWFDDENN 829
            :.|    .||.|       |..||...:..||...::|:    :..::::..:|:..|
pombe   305 VILFVIYRFLQGNMGVIGSLRSFLWVPVSQYAYRAISTKALRHVLNLSYDFHLNKRAG------- 362

  Fly   830 SVGALSARLSGEAVD-----IQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIV 889
              ..|:|...|.:::     :...||..|..:..|:..|.  :...:|:...:.::.|..|.:.|
pombe   363 --EVLTALTKGSSLNTFAEQVVFQIGPVLLDLGVAMVYFF--IKFDIYFTLIVLIMTLCYCYVTV 423

  Fly   890 GSVILEAKMMS-NAVVREKQV--IEEACRIATESITNIRTVAGLRREADVIREYTEEI--QRVEV 949
                   |:.| ....|.|.|  ..|:..:..::|.|..||...  :||   ::..|.  ..|::
pombe   424 -------KITSWRTEARRKMVNSWRESYAVQNDAIMNFETVKNF--DAD---DFENERYGHAVDI 476

  Fly   950 LIRQKLRWRGVLN--STMQASAF-FAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQS 1011
            .::|:.:....||  :.:|...| |:.|:|.......|:.|.....|.:    .||...:.|.|.
pombe   477 YLKQERKVLFSLNFLNIVQGGIFTFSLAIACLLSAYRVTFGFNTVGDFV----ILLTYMIQLQQP 537

  Fly  1012 LAF----TPAFSAALIAGHRLFQILDRKPKIQSPMGTIKNTLAKQLNLFEG-VRYRGIQFRY-PT 1070
            |.|    ..:...::|...||.:|.:.||.:      ::...|..|.:.:| |.:..:.|.| |.
pombe   538 LNFFGTLYRSLQNSIIDTERLLEIFEEKPTV------VEKPNAPDLKVTQGKVIFSHVSFAYDPR 596

  Fly  1071 RPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVR 1135
            :|   :|:.::.....|:.:||||.||.||||.:::|.|::|.:.|:|.||..||: ::||..:|
pombe   597 KP---VLSDINFVAQPGKVIALVGESGGGKSTIMRILLRFFDVNSGSITIDDQDIR-NVTLSSLR 657

  Fly  1136 TKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQ 1200
            :.:|:|.|:.|||..:|..||.|.  :.|.:..||.||||:|..|..|:..|:||::|:|.||.:
pombe   658 SSIGVVPQDSTLFNDTILYNIKYA--KPSATNEEIYAAAKAAQIHDRILQFPDGYNSRVGERGLK 720

  Fly  1201 LSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNA 1265
            ||||:|||:|:|||::::|.|:||||||||||..:|:.:|.||:...||||.|||||||||:.||
pombe   721 LSGGEKQRVAVARAILKDPSIILLDEATSALDTNTERQIQAALNRLASGRTAIVIAHRLSTITNA 785

  Fly  1266 DVICVIQNGQVVEQGNHMQLISQ-GGIYAKL 1295
            |:|..|.||::||.|.|.:||.: ||.|.|:
pombe   786 DLILCISNGRIVETGTHEELIKRDGGAYKKM 816

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747
		MdlB	711..1299	CDD:440747	196/635 (31%)
hmt1	NP_588371.3	ATM1	229..828	CDD:444078	196/639 (31%)