Protein Alignment Mdr65 and Abcb11

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_066302.2
• Gene: Abcb11 / 27413
• MGIID: 1351619
• Length: 1321
• Species: Mus musculus
• Alignment Length: 1346
• Identity: 509/1346 - (37%)
• Similarity: 770/1346 - (57%)
• Gaps: 105/1346 - (7%)

  Fly     2 ERDEVSTSSSEGKSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVV 66
            |.|....:..:.:.|:: ...||..    :.|.:|||||:..:...:|.|.:...:..:..|.::
Mouse    21 ESDGFHNNDKKSRLQDK-KKGEGAR----VGFFELFRFSSSKDNWLMFMGSVCALLHGMAQPGMI 80

  Fly    67 IIYSEFTSMLVDRAMQ------------------FGTSSNVHALPLFGGGKTLTNASR----EEN 109
            |::...|.:.|:..::                  ..:|.|          :.:||.:.    :.|
Mouse    81 IVFGILTDIFVEYDIERQELSIPEKVCMNNTIVWINSSFN----------QNMTNGTSCGLVDIN 135

  Fly   110 NEALYDDSISYGILLTIASVVMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASK 174
            :|.:....|..|:     .|.:.|.|.|.:.::.:...||:.:||...|..::|.:|||.|..|.
Mouse   136 SEVIKFSGIYAGV-----GVAVLILGYFQIRLWVITGARQIRKMRKFYFRRIMRMEIGWFDCTSV 195

  Fly   175 QNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLV----ILLN 235
            ........||:.||.:.|::::..|:..:...:..:.:.|..||||||.:.:..||:    .::.
Mouse   196 GELNSRFSDDINKIDEAIADQMALFLQRLSTALSGLLLGFYRGWKLTLVILAVSPLIGIGAAVIG 260

  Fly   236 YYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAF 300
            ..||||    |..|.::||.||::|:|:|||||||.:||||..||:|||..|:.|::...|||..
Mouse   261 LSVAKF----TELELKAYAKAGSIADEVLSSIRTVAAFGGENKEVERYEKNLMFAQRWGIWKGMV 321

  Fly   301 SGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLE 365
            .|.....:..:::...|.|||||..|::|:     .||||..|:..|..:|:.|.||...:..||
Mouse   322 MGFFTGYMWCLIFFCYALAFWYGSRLVLDE-----GEYTPGTLIQIFLCVIIAAMNIGNASSCLE 381

  Fly   366 SFATARGCATNLFKVIDLTSKIDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRI 430
            .|:|....|:::|:.||....:|.:|.||..|: .::|::||.:|.|.|||||||.:...|::.|
Mouse   382 IFSTGCSAASSIFQTIDRQPVMDCMSGDGYKLD-RIKGEIEFHNVTFHYPSRPEVKILNNLSMVI 445

  Fly   431 RAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLG 495
            :.|:|.|.|||||.||||.:||:||||||..|.|.||..|||..||:|||..|.:|.||||||..
Mouse   446 KPGETTAFVGSSGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFST 510

  Fly   496 TIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQ 560
            |||:||..|:..||.::|..||..|.|:.||..||:.:.:::||.|.|:|||||||:|||||||:
Mouse   511 TIAENIRLGREEATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIR 575

  Fly   561 NPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSH 625
            .|||||||.||||||.:||.:||.||:....|.|.|.|:||||.:|.||.|:....|..:|.|:|
Mouse   576 KPKILLLDMATSALDNESEAKVQGALNKIQHGHTIISVAHRLSTVRSADVIIGFEHGTAVERGTH 640

  Fly   626 DDLMALEGAYYNMVRAGDINMPDEVEKEDSIE-------DTKQK--SLALFEKSFETSPLNFEKG 681
            ::|:..:|.|:.:|...  :..|...||..|:       ||.::  |...::.|...|.....|.
Mouse   641 EELLERKGVYFMLVTLQ--SQEDNTHKETGIKGKDTTEGDTPERTFSRGSYQDSLRASIRQRSKS 703

  Fly   682 QKNSVQFEEPII----KALIKDTN-----AQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTI 737
            |.:.:..|.|:.    |:..:|..     .:..|..|.:        |||:....||.|:::|.:
Mouse   704 QLSHLSHEPPLAIGDHKSSYEDRKDNDVLVEEVEPAPVR--------RILKYNISEWPYILVGAL 760

  Fly   738 SAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRRTAVLSWACLGLAFLTGLVC------FLQTYL 796
            .|...|.:.|.::::|.:.....:..|.|.  :|:.:.| .||   |...|.|      |||.|.
Mouse   761 CAAINGAVTPIYSLLFSQILKTFSLVDKEQ--QRSEIYS-MCL---FFVILGCVSLFTQFLQGYN 819

  Fly   797 FNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALS 861
            |..:|..||.|:|...|.||:.|::|||||..|:.|.|:.||:.:|..:|||.|..:..|:.:.:
Mouse   820 FAKSGELLTKRLRKFGFKAMLRQDIGWFDDLKNNPGVLTTRLATDASQVQGATGSQVGMMVNSFT 884

  Fly   862 NFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRT 926
            |...:|.:|..:||||:|:.....|.:..|..::.||::....::|:::|:|.:|..|:::||||
Mouse   885 NIFVAVLIAFLFNWKLSLVISVFFPFLALSGAVQTKMLTGFASQDKEILEKAGQITNEALSNIRT 949

  Fly   927 VAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQASAFFAYAVALCYGGVLVSEGQLPF 991
            |||:..|...|:.:..|:::......:|....|:..:..|..:|.|.:.|..|||.|:....|.|
Mouse   950 VAGIGVEGRFIKAFEVELEKSYKTAIRKANVYGLCYAFSQGISFLANSAAYRYGGYLIVYEDLNF 1014

  Fly   992 QDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQILDRKPKIQSPMGTIKNTLAKQLNLF 1056
            ..:.:|..::...:..:.::.::||:::.|.|:..|.||:|||||.|....|.     .::.:.|
Mouse  1015 SYVFRVVSSIAMSATAVGRTFSYTPSYAKAKISAARFFQLLDRKPPIDVYSGA-----GEKWDNF 1074

  Fly  1057 EG-VRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHI 1120
            :| :.:...:|.||:|||.::||||.:.|..|||:|.||.|||||||.:|||:|:||||:||:.|
Mouse  1075 QGKIDFIDCKFTYPSRPDIQVLNGLSVSVDPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMI 1139

  Fly  1121 D-HDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFII 1184
            | ||  ...:.:..:|:.:|||||||.||:.||.:||.||||.:.:|:...|||||.|..|.|::
Mouse  1140 DGHD--SKKVNVQFLRSNIGIVSQEPVLFDCSIMDNIKYGDNTKEISVERAIAAAKQAQLHDFVM 1202

  Fly  1185 SLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSG 1249
            |||..|:|.:|.:|:|||.|:|||||||||:||:||||||||||||||.:||:.||.|||.|..|
Mouse  1203 SLPEKYETNVGIQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQLALDKAREG 1267

  Fly  1250 RTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQGGIYAKL 1295
            ||||||||||||:||:|:|.|:..|.|:|:|.|.:|:.|.|.|.||
Mouse  1268 RTCIVIAHRLSTIQNSDIIAVMSQGVVIEKGTHKKLMDQKGAYYKL 1313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	225/526 (43%)
		MdlB	711..1299	CDD:440747	244/593 (41%)
Abcb11	NP_066302.2	PTZ00265	29..1314	CDD:240339	507/1338 (38%)
		Interaction with HAX1. /evidence=ECO:0000250	651..674		5/24 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	662..722		13/59 (22%)