Protein Alignment Mdr65 and haf-8

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_502776.1
• Gene: haf-8 / 190369
• WormBaseID: WBGene00001818
• Length: 633
• Species: Caenorhabditis elegans
• Alignment Length: 624
• Identity: 208/624 - (33%)
• Similarity: 306/624 - (49%)
• Gaps: 100/624 - (16%)

  Fly    47 WLFFGFIMCCIKALTLPAVVIIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNE 111
            |.:|           :||..::..:....|::.|:.               |:.:|||.:.:
 Worm    54 WRWF-----------VPAYTLLILDCALNLIEPALY---------------GQMMTNAIQMK--- 89

  Fly   112 ALYDDSISYGIL----LTIASVVMFISGIFSVDVFNMVALRQVT--RMRIKLFSSVIRQDIGWHD 170
                   |:.|:    |.:|.:....:...|...|.|....::|  .:||:||.|::.|:|.:.|
 Worm    90 -------SFDIIKRACLLLALIQFSEATCKSACYFFMQYAEKLTARNIRIQLFRSILHQEISFFD 147

  Fly   171 LASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLN 235
            ..........:..|.|.|.:.:...:...|..:..|..::.|.|.|.|:|||......|:.:|:.
 Worm   148 ENKTGQLVSRITHDSESISNTLPVHIETLVNNLFMFFGSIPIMFCYSWQLTLTSFIEFPITLLMT 212

  Fly   236 YYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAF 300
            .|......||:.:|.::.|.:....||:||:||||.||..|..|.:||      .:....|   |
 Worm   213 RYYGLAVEKLSEKENDATAASNETVEEVLSAIRTVRSFAAENFEQKRY------TKNTEDW---F 268

  Fly   301 SGLSDAVLKSMLYLSCAGAFW-------------YGVNLIIDDRNVENKEYTPAILMIAFFGIIV 352
            ...:..|....:|    ..||             ||..|.::.|      ..|..|:...|
 Worm   269 KISTKTVTLGTIY----NYFWALMLRSQDVIRYLYGGYLALNGR------MAPEALLTFIF---- 319

  Fly   353 GADNIARTAPFLESFATARGCATNLF----KVIDLTSKIDPLSTDGKLLNYG-------LRGDVE 406
                      :.....||....::||    |.|.|:.|:..|......|:|.       ::|.:|
 Worm   320 ----------YHWRLHTAINAFSSLFSGVMKTIGLSRKVIHLINRKPQLDYDFGTETPEIQGKIE 374

  Fly   407 FQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDI 471
            |:.|.|.||:|..|.|..|:|:.|.:|:||||||.||.||||.|.|:|:||.|..|.:|.|.:.|
 Worm   375 FEVVEFAYPTRKTVNVINGINLSIESGKTVALVGPSGNGKSTLVSLIQQFYTPQSGRILTDGIPI 439

  Fly   472 RKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPESYRSM 536
            :..|.|...||||:|.|||.||.|||.:||.:|....|::.:..||..|..|||::.:.:.|.:.
 Worm   440 QNINHQHYHSNIALVAQEPTLFSGTIRENILFGIENGTEEAMLKAAEMANVHEFVSKMDDGYDTK 504

  Fly   537 IGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHR 601
            .||:|.|:|||||||||||||||:||::|:|||||||||.:||..||:||:..:|.||.||::||
 Worm   505 CGEKGVQMSGGQKQRIAIARALIRNPRVLILDEATSALDSESEGMVQEALNKCAKERTVIVIAHR 569

  Fly   602 LSAIRGADKIVFIHDGKVLEEGSHDDLMA-LEGAYYNMV 639
            ||.:|.|.||..|.:|.|.|.|.||:||. .:|.||.:|
 Worm   570 LSTVRKAQKIAVIENGSVKEMGCHDELMENQDGLYYKLV 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	198/553 (36%)
		MdlB	711..1299	CDD:440747
haf-8	NP_502776.1	3a01208	20..608	CDD:273363	207/622 (33%)