Protein Alignment Mdr65 and pgp-7

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_001361833.1
• Gene: pgp-7 / 188697
• WormBaseID: WBGene00004001
• Length: 1152
• Species: Caenorhabditis elegans
• Alignment Length: 1195
• Identity: 357/1195 - (29%)
• Similarity: 603/1195 - (50%)
• Gaps: 105/1195 - (8%)

  Fly    26 EPTEPIAFLK-LFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIYSEFTSMLVDRAMQFGTSSNV 89
            :|.|..:|:: :|:.::..|......|.....:..|..|.|.....|...:||
 Worm    20 KPLELCSFIRVIFKCTSCFEKFLFLIGVFFSLVTGLCQPFVSYTLGETAQVLV------------ 72

  Fly    90 HALPLFGGGKTLTNASREENNEAL-----------YDDSISYGILL--TIASVVMFISGIFSVDV 141
                      |:|||.   ||:.:           |:..: |.::|  .:.....|........:
 Worm    73 ----------TITNAI---NNKTIDPADLKKAYEQYERGM-YQVVLYFFLCGCAYFTFASIQHAI 123

  Fly   142 FNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKVGHFVYLVVGF 206
            ...|......|:|.:..|.::|:|..:.|..|..:.:..:.|::|:.|:..:||:.....|:..|
 Worm   124 MKYVGDNTTYRVRKQYISRLLRKDAEYFDNVSTGHLSTVLNDNLERFREVFNEKIALIFALLTDF 188

  Fly   207 IITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQG--------KLTAREQESYAGAGNLAEEI 263
            ::..|::|...|:|    :||   .|..:..:| |.|        |.|.::...||.||::|.:.
 Worm   189 VVGTALAFYTDWRL----ASY---GIFFSLGIA-FSGFINSAGVMKTTGKQNTHYANAGSIAFQT 245

  Fly   264 LSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAG----AFWYGV 324
            |.:.:||.|..|:.:|::||...|    ||.:..|....|..::.:...|..|..    ..:.|.
 Worm   246 LGAYKTVCSLNGQNTEIERYTEEL----KAGEKYGIHRALMYSISRGFTYFFCNSLNTVILYVGA 306

  Fly   325 NLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDP 389
            |:|.      :....||:::..|..::.||..::...|.:...|   |..::...:.::..|.|.
 Worm   307 NMIY------SGSLEPAVVVRIFHYMMFGAFCLSEALPHISRLA---GAISSTAPIAEMLIKEDN 362

  Fly   390 L----STDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCV 450
            :    .||.. :...:.|::.|::|.|.||:||:..|.:|::..::.|:.:||||:||.||||.|
 Worm   363 VIEKDETDYD-VEVEVNGNISFKNVKFSYPTRPDAQVLKGISFDVQNGECIALVGASGSGKSTVV 426

  Fly   451 QLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEA 515
            |||..:|:...|::.:|.:|:...||:.||..|.||.||||||..||.:||.:|.|..:..||..
 Worm   427 QLLLHYYNIDSGNIFIDGMDLNDMNIKRLRRVIGVVSQEPVLFNTTIEENIRFGNPNVSLPEIYG 491

  Fly   516 AATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEK 580
            |..:|.|::|:.:.|:..::::||||:||||||||||||||.|::|||||||||||||||.:||:
 Worm   492 ALRKANAYDFVCSFPKGIKTIVGERGTQLSGGQKQRIAIARTLVRNPKILLLDEATSALDNESEQ 556

  Fly   581 QVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVRAGDIN 645
            .||:||:.||:|||||||:||||.||.|.||:.:..|:::|.|:||:|:|..|.|.::|:|
 Worm   557 VVQKALENASQGRTTIVVAHRLSTIRNASKIIVMQKGEIVEVGNHDELIAKRGVYNDLVQA---- 617

  Fly   646 MPDEVEKEDSIEDTKQKSLALFEKSFETSPLN---FEKGQKNSVQFEEPIIKALIKDTNAQSAEA 707
              ..:|..|..|:.  ..||..:.|.|.|||:   .::...|.....:..::.::.:.:.:.|
 Worm   618 --QLLESHDDHEEL--PPLAARQLSQELSPLHSYAIQRSTSNDAGVHDDDMERILDELSKEGA-- 676

  Fly   708 PPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKDPEDALRRT 772
              :|.|    ...|::..:.::|:|.:....:...|..||..|.:....|...| ...||.|..:
 Worm   677 --KKSN----LREIVKQCRPDYCFLFIAVFGSAIQGVSYPILAQLIVRTYEGFA-MIGEDMLYYS 734

  Fly   773 AVLSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALSAR 837
            .:.:.:.:.||....|..:.|.|.|......|:||:|..:|:.|::....::||.|:|...||.|
 Worm   735 HLWALSFMFLAVFRPLTLYCQYYYFGKVSEQLSTRLRIKSFSHMLSLPCAFYDDPNHSATRLSNR 799

  Fly   838 LSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMSNA 902
            |:.::.:::.|:...|..:|..:.....:::.|..|.||:.|..|...|::..:..........:
 Worm   800 LNTDSSNVKAAVDDRLGCVIMTVVAISIAITTASLYCWKMTLEVLIFFPLLYLAEYCYDAATETS 864

  Fly   903 VVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTMQA 967
            :..:....|.:.|.|.|::.|:|||..|..|..::...:|.:|::.....::...:|..|....:
 Worm   865 IQEDTIAFENSNRTAIEALENMRTVRALNLEDKIMSLISEHLQKIHKSYFKRAIIQGAANGLSLS 929

  Fly   968 SAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQIL 1032
            ...|.|:|:..:|..|....::...|...:.|||...:.|...:.|:.|.:..|:.|...:|.:.
 Worm   930 CYLFVYSVSFKFGTYLALRKEVAPMDTYLILETLSMTANMAGSAAAYLPDYKKAVHAAGLIFHLF 994

  Fly  1033 DRKPKIQSPMGTIKNTLAKQLNLFEGVRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVGHSG 1097
            .....:.......|..:.|...:.|.|     ||.|..|||..||||::|:|..|:|:||||.||
 Worm   995 TYPATMPFSSSDGKKNIEKGEIIGENV-----QFHYDQRPDRMILNGVNLKVDPGKTLALVGPSG 1054

  Fly  1098 CGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYGDNR 1162
            |||||.:.||:|:|...:|.:.||.:::: |:.|:.:|:.|.:||||||||..||.||:.|| ..
 Worm  1055 CGKSTIISLLERFYHAVDGEVKIDSENVE-DINLNHLRSNLALVSQEPTLFNCSIRENLLYG-LT 1117

  Fly  1163 RSVSMVEIIAAAKSANAHSFIISLP 1187
            |||..:|:..|.::|||.:|:...|
 Worm  1118 RSVPQLELEKALQTANAFNFVFQFP 1142

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	188/540 (35%)
		MdlB	711..1299	CDD:440747	137/477 (29%)
pgp-7	NP_001361833.1	MdlB	40..622	CDD:440747	203/635 (32%)
		ABC_6TM_Pgp_ABCB1_D2_like	686..994	CDD:350022	70/308 (23%)
		TM helix 1	695..718	CDD:350022	5/22 (23%)
		TM helix 2	733..781	CDD:350022	12/47 (26%)
		TM helix 3	790..835	CDD:350022	10/44 (23%)
		TM helix 4	836..885	CDD:350022	9/48 (19%)
		TM helix 5	897..947	CDD:350022	9/49 (18%)
		TM helix 6	956..989	CDD:350022	8/32 (25%)
		P-loop containing Nucleoside Triphosphate Hydrolases	1019..>1143	CDD:476819	62/131 (47%)