Protein Alignment Mdr65 and pgp-10

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_509205.2
• Gene: pgp-10 / 180981
• WormBaseID: WBGene00004004
• Length: 1382
• Species: Caenorhabditis elegans
• Alignment Length: 1401
• Identity: 413/1401 - (29%)
• Similarity: 688/1401 - (49%)
• Gaps: 187/1401 - (13%)

  Fly     5 EVSTSSSEGKSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVVIIY 69
            :|:......||.:..|.....||     :.:|:.|:...::..:..|.....:::...|.|.:|.
 Worm    59 DVTMDDPLDKSSDSKPKLGFFEP-----YKRLYAFADSIDMQLMAMGLFSALLQSALPPFVWLIM 118

  Fly    70 SEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYG-----ILLTIASV 129
            ..|.|:.:.|  :.|..          |.|.||       ::...||..::.     |.:...|:
 Worm   119 GNFVSISILR--EEGKL----------GLKNLT-------SDYPIDDQFAHSATPAFISMLGLSI 164

  Fly   130 VMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISE 194
            .|||:.......:.:.::|||.|::......::..||.|.:.....:....:.:..:.|.:|||:
 Worm   165 AMFIAAFCQRIAWEISSIRQVFRIKKAYIRKLLLMDISWLESRQSGHVAAMLQESADSIYNGISD 229

  Fly   195 KVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNL 259
            .:...|:::...::.:.:.....|.:||.:...|||:|:.....:|:.......|.:......||
 Worm   230 HLPMVVFILSYLLVNIGVCLYIQWDVTLFMCLAIPLLIISRILYSKWFANTMEEETKLQNKITNL 294

  Fly   260 AEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWK----GAFSGLSDAVLKSMLYLSCAGAF 320
            ..|..:.|.||:||..:|.::.::|.......|.::.:    ..|..|:..:|..:::   .||.
 Worm   295 VNETFNCITTVISFAAQKQKINKFEKLSAEHSKLTEERLRSSVVFDSLTQILLTELIF---TGAL 356

  Fly   321 WYGVNLIIDDRNVENKEYTPAI--LMIAFFGIIVGADNIARTAPFLESFAT-ARGCATNLFKVID 382
            .||:..:.|  |...:....||  |.:....|.:|         |..:.|| |:..|..:.:|::
 Worm   357 CYGIWRVAD--NSPGRLCALAINMLYMCVTSISIG---------FHMNGATRAKDNAKEICEVLN 410

  Fly   383 LTSKIDP--LSTDGKL--------------LNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIR 431
            ...||:.  .|.|..:              :.:..:|.:.|:|:.|.||||.|..|.||::.::.
 Worm   411 EQPKIEVELASIDNNIDYVPVTRCKYRRQSMKFMGKGALHFRDIHFSYPSRKETEVLRGISFKVE 475

  Fly   432 AGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGT 496
            ||:.:|:|||||.||||...||.|||||..|::|||..:|:......||...::|.||||||.||
 Worm   476 AGEKIAIVGSSGSGKSTLTALLLRFYDPTKGAILLDGENIKTMCPDDLRGQCSLVSQEPVLFDGT 540

  Fly   497 IAQNISYGKPGATQKEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQN 561
            |:.||.||:..|||:||..||.:.||.:||.:||:..::.:||||.|||||||||:|||||:|:.
 Worm   541 ISDNIRYGRLDATQQEINDAARKVGAWKFINSLPDGMQTRVGERGHQLSGGQKQRVAIARAVIRK 605

  Fly   562 PKILLLDEATSALDYQSEKQVQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHD 626
            |.:|:.||||||||...|::|..|:||||:|.|||.::||||.|:.:|:|:.:|:||::|||..|
 Worm   606 PIVLIFDEATSALDNIHEEEVNAAIDLASEGLTTITIAHRLSTIKNSDRIIVLHEGKIVEEGVPD 670

  Fly   627 DLMA-LEGAYYNMVRAGDINMPDEVEKEDSIEDTKQKSLALFEKSFETSPLNFEKGQK------- 683
            :|:| ..|.::.|.  .|..:....::...:...:.|..:|.::...:.|.|.:..|:
 Worm   671 ELIADANGIFHKMY--NDQRLDQLTQQHQQLHQQQAKPPSLQQQMSFSPPPNMDPDQQRRAWARS 733

  Fly   684 --------------NSVQFEEPIIKALIK----------------------DTNAQSAEAPPEKP 712
                          ||::.|:..:..:.|                      |:.....:.|.::.
 Worm   734 SLGGNKKLGKSYSVNSMEKEKLKLPVMSKKKSERLDYKYSKVHSMDVKQHTDSMHDDDDLPGKET 798

  Fly   713 NFFRTFSRILQLAKQEWCYLILGTISAV---AVGFLYPAFAVIFGEFYAALAE----KDPEDALR 770
            ||  |..:.|..:.:....|:.|.|...   ||.:|...|.|      |::.|    .|.|.||:
 Worm   799 NF--TVLKDLIYSYRTGLPLLAGAIPTTIVRAVFYLLICFQV------ASVLEISIAPDEERALQ 855

  Fly   771 RTAVLSWACLGLAFLTGLV-----------CFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWF 824
            ...|       .|..|.|:           .|:..|     |......||...|..::.....:|
 Worm   856 IFIV-------AAIYTALIIVKTIFEALGRIFIALY-----GHGFCKFMRNEMFRKVLRHGAAYF 908

  Fly   825 DDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIV 889
            |:|.||.|.|..::..|:..:...:...|..:|..:...:.|:..|::.|||:||||....|...
 Worm   909 DEERNSPGRLVHKVINESSTLNEIMEQKLDMLIPGVVCSLFSIVCALWINWKMALLCSFQFPAYF 973

  Fly   890 GSVILEAKMMSNAVVREKQVIEE---ACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLI 951
            ...||:.:   ....|::|:::|   |..:|:..:.|:.|:.....::.....:.:.::.|...:
 Worm   974 VIRILQIR---EGTKRQRQMVDEEKKAANLASVVLANMSTIKAYNLQSHFYNVFCDALKPVSQCM 1035

  Fly   952 RQKLRWRGVLNSTMQASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTP 1016
            :::.....::.:...:..:...|:.|.:|.|::...::...|.::|.....:|:...:|.:|...
 Worm  1036 QKQSLISALVFACQYSFTYILIAITLHFGKVMMLANEISVFDYMRVVLLTQFGANFFSQLIASVS 1100

  Fly  1017 AFSAALIAGHRLFQILDRKPKIQSPMGTIKNTLAKQLNLFEGVR--------YRGIQFRYPTRPD 1073
            .|:.|.||...:.::: |:|.:.      .:.|::     ||:|        .:.:.||||:||.
 Worm  1101 DFTKAQIAAENVMRVI-REPPVD------MDNLSE-----EGLRPKLEGNLCLKDVSFRYPSRPI 1153

  Fly  1074 AKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKL 1138
            ..:|..|:|:|..|:::||||.||.|||:.:.|.||.|:..:|.:.||..:|: .:....:|..:
 Worm  1154 VPVLTNLNLKVRGGESIALVGPSGSGKSSVISLFQRMYNATDGVVIIDKYNIK-SINPAYLRRCI 1217

  Fly  1139 GIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSG 1203
            ..|.|||.||..:|.||||:|......::.::|.|||.|:.|:||.|||.||||.:|..|.||||
 Worm  1218 VQVGQEPDLFSFTIKENIAFGMMESEATIDKVIEAAKIADIHNFITSLPQGYDTEVGEFGAQLSG 1282

  Fly  1204 GQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALD-------TACSGRTCIVIAHRLST 1261
            |||||||||||::|.|.:|||||||||||..||:.||.|.:       |.|   |||.|||||||
 Worm  1283 GQKQRIAIARAIIRKPTVLLLDEATSALDSASEREVQNAFERVKRSTKTQC---TCIQIAHRLST 1344

  Fly  1262 VQNADVICVIQNGQVVEQGNHMQLISQGGIYAKLHK 1297
            ::|.|.|.||.:|::.|:|:|.|||:..|||.::::
 Worm  1345 IRNVDKIYVIVHGEIAEEGSHEQLINLKGIYYEMNQ 1380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	184/551 (33%)
		MdlB	711..1299	CDD:440747	195/623 (31%)
pgp-10	NP_509205.2	MdlB	76..687	CDD:440747	202/650 (31%)
		MdlB	796..1378	CDD:440747	195/620 (31%)