Protein Alignment Mdr65 and pgp-1

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_502413.1
• Gene: pgp-1 / 178215
• WormBaseID: WBGene00003995
• Length: 1321
• Species: Caenorhabditis elegans
• Alignment Length: 1332
• Identity: 501/1332 - (37%)
• Similarity: 753/1332 - (56%)
• Gaps: 85/1332 - (6%)

  Fly     2 ERDEVSTSSSEGKSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVV 66
            |.|.:. |:.|.|...:|..    |....::..:|:|::|..|...||.|.::..|....||.:.
 Worm    36 EGDNID-SNGEIKITRDAKE----EVVNKVSIPQLYRYTTTLEKLLLFIGTLVAVITGAGLPLMS 95

  Fly    67 IIYSEFTSMLVDRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVVM 131
            |:..:.:...::..:....:.:.. ||. |...|.|:...:..|...     ||..:    :|.|
 Worm    96 ILQGKVSQAFINEQIVINNNGSTF-LPT-GQNYTKTDFEHDVMNVVW-----SYAAM----TVGM 149

  Fly   132 FISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEKV 196
            :.:|..:|..:..||.:...|:|.:...|::||:|.|.|..........:.|::|::::|..:|:
 Worm   150 WAAGQITVTCYLYVAEQMNNRLRREFVKSILRQEISWFDTNHSGTLATKLFDNLERVKEGTGDKI 214

  Fly   197 G-HFVYL---VVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAG 257
            | .|.||   :.|||    ::|::.|:|||.:.:..|:..|..:.:||.......||...||.||
 Worm   215 GMAFQYLSQFITGFI----VAFTHSWQLTLVMLAVTPIQALCGFAIAKSMSTFAIRETLRYAKAG 275

  Fly   258 NLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWY 322
            .:.||.:||||||||..|.:.|::||...:..|:||...||.|.|:|...:::..::|.|.||:.
 Worm   276 KVVEETISSIRTVVSLNGLRYELERYSTAVEEAKKAGVLKGLFLGISFGAMQASNFISFALAFYI 340

  Fly   323 GVNLIID-DRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSK 386
            ||..:.| ..|..:       ::..|..:::|:..:....|.|....||:|.|:.:::|:|....
 Worm   341 GVGWVHDGSLNFGD-------MLTTFSSVMMGSMALGLAGPQLAVLGTAQGAASGIYEVLDRKPV 398

  Fly   387 IDPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQ 451
            ||..|..|: .:..::||:..::|.|.|||||:|.:.||:|:|:.|||||||||||||||||.:.
 Worm   399 IDSSSKAGR-KDMKIKGDITVENVHFTYPSRPDVPILRGMNLRVNAGQTVALVGSSGCGKSTIIS 462

  Fly   452 LLQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAA 516
            ||.|:||.:.|.:.:|.:|:|..|:::||.|:|||.|||.||..||.:|||.||.|.|::|:.||
 Worm   463 LLLRYYDVLKGKITIDGVDVRDINLEFLRKNVAVVSQEPALFNCTIEENISLGKEGITREEMVAA 527

  Fly   517 ATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQ 581
            ...|.|.:||..||..|.:::|:||:||||||||||||||||::|||||||||||||||.:||..
 Worm   528 CKMANAEKFIKTLPNGYNTLVGDRGTQLSGGQKQRIAIARALVRNPKILLLDEATSALDAESEGI 592

  Fly   582 VQQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVRA----- 641
            ||||||.|:||||||:::||||.||.||.|:...:|:|:|.|.|..|||.:|.||::|.|
 Worm   593 VQQALDKAAKGRTTIIIAHRLSTIRNADLIISCKNGQVVEVGDHRALMAQQGLYYDLVTAQTFTD 657

  Fly   642 -------GDINMPDEVEKEDS-----------IEDTKQKSLALFEKSFETSPLNFEKGQKNSVQF 688
                   |..:..:.|.::.|           ::|...:..:....|....|:..||
 Worm   658 AVDSAAEGKFSRENSVARQTSEHEGLSRQASEMDDIMNRVRSSTIGSITNGPVIDEK-------- 714

  Fly   689 EEPIIKALIKDTNAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIF 753
            ||.|.|..:.....:..|...:|.|.|    .||..|:.....|.:|..:|...||:||.::|.|
 Worm   715 EERIGKDALSRLKQELEENNAQKTNLF----EILYHARPHALSLFIGMSTATIGGFIYPTYSVFF 775

  Fly   754 GEFYAALAEKDPEDALRRTAVLSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVN 818
            ..|....| .:|.|.|.:....:...|.||...|:..||.|:....|...||..:|...|..:::
 Worm   776 TSFMNVFA-GNPADFLSQGHFWALMFLVLAAAQGICSFLMTFFMGIASESLTRDLRNKLFRNVLS 839

  Fly   819 QEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLA 883
            |.:|:||...|:.|.:|.||:.:..:::.||.:..|.:|..|.:.::.:.:|.:|.|::|||.:|
 Worm   840 QHIGFFDSPQNASGKISTRLATDVPNLRTAIDFRFSTVITTLVSMVAGIGLAFFYGWQMALLIIA 904

  Fly   884 NCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEI---- 944
            ..||:.....|..:..:...|:......::.:||.|:|.|:|||..|.||......:.|::
 Worm   905 ILPIVAFGQYLRGRRFTGKNVKSASEFADSGKIAIEAIENVRTVQALAREDTFYENFCEKLDIPH 969

  Fly   945 -QRVEVLIRQKLRWRGVLNSTMQASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMML 1008
             :.::....|.|.: |..:|.:......||.:.|..  ::.....:....:::|...:...:..|
 Worm   970 KEAIKEAFIQGLSY-GCASSVLYLLNTCAYRMGLAL--IITDPPTMQPMRVLRVMYAITISTSTL 1031

  Fly  1009 AQSLAFTPAFSAALIAGHRLFQILDRKPKIQSPMGTIKNTLAKQLNLFEGVRYRGIQFRYPTRPD 1073
            ..:.::.|.::.|..||..:|.:|.:..||.|     .:...::..|:..|.::.::|.||.||:
 Worm  1032 GFATSYFPEYAKATFAGGIIFGMLRKISKIDS-----LSLAGEKKKLYGKVIFKNVRFAYPERPE 1091

  Fly  1074 AKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKL 1138
            .:||.||...|..|||:||||.|||||||.|.||:|:||...|.|.||..:|: .|..:..|:::
 Worm  1092 IEILKGLSFSVEPGQTLALVGPSGCGKSTVVALLERFYDTLGGEIFIDGSEIK-TLNPEHTRSQI 1155

  Fly  1139 GIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSG 1203
            .|||||||||:.||||||.||.:..||:|.::..||:.||.|:||..||.|::||:|.|||||||
 Worm  1156 AIVSQEPTLFDCSIAENIIYGLDPSSVTMAQVEEAARLANIHNFIAELPEGFETRVGDRGTQLSG 1220

  Fly  1204 GQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVI 1268
            |||||||||||||||||||||||||||||.:||::||:|||.|..|||||||||||:||.|||.|
 Worm  1221 GQKQRIAIARALVRNPKILLLDEATSALDTESEKVVQEALDRAREGRTCIVIAHRLNTVMNADCI 1285

  Fly  1269 CVIQNGQVVEQGNHMQLISQGGIYAKLHKTQK 1300
            .|:.||.::|:|.|.||:|:.|.|.||  |||
 Worm  1286 AVVSNGTIIEKGTHTQLMSEKGAYYKL--TQK 1315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	227/527 (43%)
		MdlB	711..1299	CDD:440747	233/592 (39%)
pgp-1	NP_502413.1	MdlB	131..653	CDD:440747	228/542 (42%)
		MdlB	733..1319	CDD:440747	236/599 (39%)