Protein Alignment Mdr65 and pgp-2

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_001300410.1
• Gene: pgp-2 / 172262
• WormBaseID: WBGene00003996
• Length: 1296
• Species: Caenorhabditis elegans
• Alignment Length: 1333
• Identity: 495/1333 - (37%)
• Similarity: 742/1333 - (55%)
• Gaps: 93/1333 - (6%)

  Fly     2 ERDEVSTSSSEGKSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWLFFGFIMCCIKALTLPAVV 66
            :|.:.|.||....|..:       |.|..:....:|.::...::..|..|.:...|.....|.:.
 Worm    18 QRSQTSLSSHSSDSSID-------ESTVKLTNYGIFYYTQGVDLLLLITGTVAAVIHGAGFPLLA 75

  Fly    67 IIYSEFTSMLVDRAMQ----FGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIA 127
            |:....|::.: ||..    .|. .||:.       :.|...|.:|.|    .:.:.|.|...:.
 Worm    76 IVLGGMTTVFL-RAQNSDFVVGV-DNVNP-------EGLVPISLDEFN----SEVVKYCIYYLVL 127

  Fly   128 SVVMFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGI 192
            .|:||.:....:..|...|.|.|.::|.....:::||.|.|.|.....|.|..:.||:|::|:|:
 Worm   128 GVLMFFTSYVQIACFESYAERLVHKLRQNYLKAILRQQIQWFDKQQTGNLTARLTDDLERVREGL 192

  Fly   193 SEKVGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAG 257
            .:|....|.:...|:....:.|.|.|.:||.:..:.||::|....::|.....|..|||:||.||
 Worm   193 GDKFALLVQMFAAFLAGYGVGFFYSWSMTLVMMGFAPLIVLSGAKMSKSMATRTRVEQETYAVAG 257

  Fly   258 NLAEEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWY 322
            .:|||..||||||.|..|.|.|:.|:.|.|...|:....|..:.|:........:|.|.|.||||
 Worm   258 AIAEETFSSIRTVHSLNGHKRELDRFYNALEVGRQTGIVKYCYMGIGVGFSNLCMYSSYALAFWY 322

  Fly   323 GVNLIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKI 387
            |..|||:|...:.     .::...||.::.|:.::....|.|.||.||||.|:.:.:||:...||
 Worm   323 GSTLIINDPTFDR-----GLIFTVFFAVLSGSTSLGGALPHLASFGTARGAASTVLRVINSHPKI 382

  Fly   388 DPLSTDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQL 452
            ||.|.:|.|:: .::||:.|:||.||||||.::.|.:|:::.::||..:||||||||||||.|.|
 Worm   383 DPYSLEGILVD-NMKGDISFKDVHFRYPSRKDIHVLKGISLELKAGDKIALVGSSGCGKSTIVNL 446

  Fly   453 LQRFYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAA 517
            |||||||..|.||:|.:|:|:.|:..||..|.:|.||||||.|||.:||..|...||..::..|.
 Worm   447 LQRFYDPTKGRVLIDGVDLREVNVHSLREQIGIVSQEPVLFDGTIYENIKMGNEHATHDQVVEAC 511

  Fly   518 TQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQV 582
            ..|.|::||..||:.|.:.:||:|.||||||||||||||||::|||||||||||||||.::|::|
 Worm   512 KMANANDFIKRLPDGYGTRVGEKGVQLSGGQKQRIAIARALVKNPKILLLDEATSALDTEAEREV 576

  Fly   583 QQALDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMVRAGDINMP 647
            |.|||.|..|||||:|:||||.||..|:|.....|.::|.|||::||:.:|.:|:|.:|..:...
 Worm   577 QGALDQAQAGRTTIIVAHRLSTIRNVDRIFVFKAGNIVESGSHEELMSKQGIFYDMTQAQVVRQQ 641

  Fly   648 DEVEKEDSIEDT---------KQKSLALFEKSFETS------------PLNFEKGQKNSVQFEEP 691
            .:...:| ||||         .:||......|..||            |.|   ||.|     :.
 Worm   642 QQEAGKD-IEDTISESAHSHLSRKSSTRSAISIATSIHQLAEEVELIDPFN---GQTN-----QD 697

  Fly   692 IIKALIKDTNAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEF 756
            :|::.|........:|||  .:.|:.|.  ....|..|  .|.|...|...|.:.|.||:::.|.
 Worm   698 VIRSRILSAFGGECKAPP--TSMFKIFK--FNGDKVGW--FIGGIFGAFIFGSVTPVFALVYAEI 756

  Fly   757 YAALAEKDPEDALRRTAVLSW----ACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMV 817
            :...:.  |.|.::.. |..|    ..:|:.|..|.  |.........|..||.::|...|..::
 Worm   757 FNVYSL--PADQMQAN-VYFWCGMFVLMGITFFVGF--FTSANCLGRCGESLTMKLRFEAFKNLL 816

  Fly   818 NQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFIS---SVSVAMYYNWKLAL 879
            .|::.::||..:..|.|..|.:.:|.:::    |..:.:...|::.::   ::.:..||.|:|||
 Worm   817 RQDIAFYDDLRHGTGKLCTRFATDAPNVR----YVFTRLPVVLASIVTICGALGIGFYYGWQLAL 877

  Fly   880 LCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEI 944
            :.:...|::|.....|.:|.....:|:.|::|||.::|::::.:||||..|.|:......|.|.:
 Worm   878 ILVVMVPLLVMGGYFEMQMRFGKQIRDTQLLEEAGKVASQAVEHIRTVHSLNRQEQFHFTYCEYL 942

  Fly   945 QRVEVLIRQKLRWRGVLNSTMQASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLA 1009
            :.......:.....|.:.:..|:..||.||.|...|.:.|::..:...|:.:|...:.:...|:.
 Worm   943 REPFNTNLKHAHTYGAVFAFSQSLIFFMYAAAFYLGSIFVNQQAMQPIDVYRVFFAISFCGQMIG 1007

  Fly  1010 QSLAFTPAFSAALIAGHRLFQILDRKPKIQ--SPMGTIKNTLAKQLNLFEGVRYRGIQFRYPTRP 1072
            .:.:|.|....|.:|...||.:::....|.  |..|.:|       .:...:..|.:.|.||||.
 Worm  1008 NTTSFIPDVVKARLAASLLFYLIEHPTPIDSLSDSGIVK-------PITGNISIRNVFFNYPTRK 1065

  Fly  1073 DAKILNGLDLEVLKGQTVALVGHSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTK 1137
            |.|:|.|..|::..|:||||||||||||||.:.||:|:|:.|:|.|.||.|:|: :|.:..:|.:
 Worm  1066 DTKVLQGFTLDIKAGKTVALVGHSGCGKSTIMGLLERFYNQDKGMIMIDGDNIR-NLNISSLREQ 1129

  Fly  1138 LGIVSQEPTLFERSIAENIAYGDNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLS 1202
            :.|||||||||:.:|.|||.||.| |:|:..||:.|||.||.|:||:.||:||||.:|.:|||||
 Worm  1130 VCIVSQEPTLFDCTIGENICYGTN-RNVTYQEIVEAAKMANIHNFILGLPDGYDTHVGEKGTQLS 1193

  Fly  1203 GGQKQRIAIARALVRNPKILLLDEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADV 1267
            |||||||||||||||:|.:|||||||||||.:||::||:|||.|..||||:||||||||:||:||
 Worm  1194 GGQKQRIAIARALVRSPSVLLLDEATSALDTESEKIVQEALDAAKQGRTCLVIAHRLSTIQNSDV 1258

  Fly  1268 ICVIQNGQVVEQGNHMQLISQGGIYAKLHKTQK 1300
            |.::..|::||:|.|.:||.:..||.|..:||:
 Worm  1259 IAIVSEGKIVEKGTHDELIRKSEIYQKFCETQR 1291

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	228/522 (44%)
		MdlB	711..1299	CDD:440747	221/596 (37%)
pgp-2	NP_001300410.1	PTZ00265	56..1286	CDD:240339	484/1281 (38%)
		MdlB	56..632	CDD:440747	242/594 (41%)