Protein Alignment Mdr65 and haf-6

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_490828.3
• Gene: haf-6 / 171694
• WormBaseID: WBGene00001816
• Length: 668
• Species: Caenorhabditis elegans
• Alignment Length: 635
• Identity: 216/635 - (34%)
• Similarity: 320/635 - (50%)
• Gaps: 80/635 - (12%)

  Fly    41 TYGEI--------GWLFFGFIMCCIKALTLPAVVIIYSEFTSMLVDRAMQFGTSSNVHALPLFGG 97
            |.||:        || ||..::|.|    |.|.:.|                      .:||..|
 Worm    83 TAGELWNLIKPFFGW-FFAAVVCAI----LSAYINI----------------------QIPLCLG 120

  Fly    98 GKTLTNA-----SREENN-----EALYDDSISYGILLTIASVVMFISGIFSVDVFNMVALRQVTR 152
              .|.|.     ..|.||     |.|...::....|....|.:.|:    .:....::..|..|:
 Worm   121 --DLVNGIVKIIKDESNNLRSHFEQLKPSALHLMTLYVAQSALTFL----YITFLTVLGERMATK 179

  Fly   153 MRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDG----ISEKVGHFVYLV--VGFIITVA 211
            ||..||..::..|:.:.|.......:..:..||::.:..    :|:.:..|...:  :|.:..::
 Worm   180 MRSDLFQKLLHHDMAFFDSHKSGELSARLNADVQEFKSSFKLCVSQGLRTFAQTIGCIGSLYFLS 244

  Fly   212 ISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLAEEILSSIRTVVSFGGE 276
            .:      :|:...:.:|.:||....:.....:|:.|.|...|.|..:::|.|::|||:.:|..|
 Worm   245 PT------MTMYTVAVVPGIILAGSAIGAGLRQLSRRAQGQSATASAVSDEALTNIRTIRAFAME 303

  Fly   277 KSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVNLIIDDRNVENKEYTPA 341
            |.|.:.::|.|..||...:..|...||..|.....|........:.|.|||      ...|.||.
 Worm   304 KLESRLFDNELDKARAMQEQLGVGIGLFQAGTNLFLNGMILSVLYGGSNLI------SKGEMTPG 362

  Fly   342 ILMIAFFGIIVGADNIARTAPFLE-SFATARGCATNLFKVIDLTSKID---PLSTDGKLLNYGLR 402
            .||    ..:|.|..|.|:...|. .|.||....|...:|:.. |:::   |:.|...:..:.|.
 Worm   363 ALM----SFLVSAQTIQRSLSQLSIIFGTAIKGWTAGGRVLQF-SRLEPSIPMDTGVCIPYHSLW 422

  Fly   403 GDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGSVLLD 467
            ||::|:||.|.||:||...|...|.:.|.|||.|||.|.||.||||...||:|||:|..|.|.||
 Worm   423 GDIKFEDVSFSYPTRPGHTVFENLTLSIPAGQVVALCGPSGEGKSTITHLLERFYEPKSGRVTLD 487

  Fly   468 DLDIRKYNIQWLRSN-IAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQAGAHEFITNLPE 531
            ..|:|:.|::|||.. |.::.||||||..::.:||.||:|.||.:|:..||..|...||::..|.
 Worm   488 GRDLRELNVEWLRGQVIGLISQEPVLFATSVEENIRYGRPDATDEEVREAARAAHVDEFVSRFPS 552

  Fly   532 SYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQALDLASKGRTTI 596
            .|.:::||||:|||||||||||||||:::||.||:|||||||||..||..||:||:...||||.:
 Worm   553 GYSTVVGERGAQLSGGQKQRIAIARAILKNPPILILDEATSALDSHSEHMVQEALNNVMKGRTVL 617

  Fly   597 VVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYY-NMVRAGDIN 645
            :::||||.||.|..|..|.|.|.||.|:|:.|||.:|:.| .:|.|.:::
 Worm   618 IIAHRLSTIRSAQMIYVIKDKKALESGTHEQLMAKKGSLYRKLVEAHNVD 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	193/534 (36%)
		MdlB	711..1299	CDD:440747
haf-6	NP_490828.3	MdlB	87..664	CDD:440747	212/626 (34%)