Protein Alignment Mdr65 and Abcb1a

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_596892.1
• Gene: Abcb1a / 170913
• RGDID: 619951
• Length: 1272
• Species: Rattus norvegicus
• Alignment Length: 1310
• Identity: 546/1310 - (41%)
• Similarity: 795/1310 - (60%)
• Gaps: 79/1310 - (6%)

  Fly    10 SSEGKSQEEAPMAEGLEPTEPIAFLKLFRFSTYGEIGWL-----FFGFIMCCIKALTLPAVVIIY 69
            |..||..::    |..|....::.|.:||::     |||     ..|.:...|..:.||.:::::
  Rat    16 SKMGKKSKK----EKKEKKPAVSVLTMFRYA-----GWLDRFYMLLGTLAAIIHGIALPLMMLVF 71

  Fly    70 SEFTSMLV----DRAMQFGTSSNVHALPLFGGGKTLTNASREENNEALYDDSISYGILLTIASVV 130
            .:.|....    :|:|.|..:::::|           ....|....|.|...|..|:|     :|
  Rat    72 GDMTDSFANVGNNRSMSFYNATDIYA-----------KLEDEMTTYAYYYTGIGAGVL-----IV 120

  Fly   131 MFISGIFSVDVFNMVALRQVTRMRIKLFSSVIRQDIGWHDLASKQNFTQSMVDDVEKIRDGISEK 195
            .:|    .|.::.:.|.||:.::|.|.|.:::.|:|||.|:.........:.|||.||.:||.:|
  Rat   121 AYI----QVSLWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINEGIGDK 181

  Fly   196 VGHFVYLVVGFIITVAISFSYGWKLTLAVSSYIPLVILLNYYVAKFQGKLTAREQESYAGAGNLA 260
            :|.|...:..|.....|.|:.||||||.:.:..|::.|.....||.....|.:|.::||.||.:|
  Rat   182 IGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELQAYAKAGAVA 246

  Fly   261 EEILSSIRTVVSFGGEKSEVQRYENFLVPARKASQWKGAFSGLSDAVLKSMLYLSCAGAFWYGVN 325
            ||:|::||||::|||:|.|::||.|.|..|::....|...:.:|......::|.|.|.|||||.:
  Rat   247 EEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTS 311

  Fly   326 LIIDDRNVENKEYTPAILMIAFFGIIVGADNIARTAPFLESFATARGCATNLFKVIDLTSKIDPL 390
            |:|      :||||...::..||.:::||.::.:.:|.:|:||.|||.|..:|.:||....||..
  Rat   312 LVI------SKEYTIGQVLTVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFSIIDNKPSIDSF 370

  Fly   391 STDGKLLNYGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQR 455
            |..|...: .::|::||:::.|.||||.:|.:.:|||:::::||||||||:|||||||.||||||
  Rat   371 SKSGHKPD-NIQGNLEFKNIHFSYPSRKDVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQR 434

  Fly   456 FYDPVFGSVLLDDLDIRKYNIQWLRSNIAVVGQEPVLFLGTIAQNISYGKPGATQKEIEAAATQA 520
            .|||:.|.|.:|..|||..|:::||..|.||.||||||..|||:||.||:...|..|||.|..:|
  Rat   435 LYDPIEGEVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEA 499

  Fly   521 GAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALDYQSEKQVQQA 585
            .|::||..||..:.:::||||:||||||||||||||||::|||||||||||||||.:||..||.|
  Rat   500 NAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAA 564

  Fly   586 LDLASKGRTTIVVSHRLSAIRGADKIVFIHDGKVLEEGSHDDLMALEGAYYNMV---RAG-DINM 646
            ||.|.:||||||::||||.:|.||.|.....|.::|:|:||:||..:|.|:.:|   .|| :|.:
  Rat   565 LDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTAGNEIEL 629

  Fly   647 PDEV-EKEDSIED----TKQKSLALFEKSFETSPLNFEKGQKNSVQFEEPIIKALIKDTNAQSAE 706
            .:|. |.:|.|::    :|....:|..:......:.....|...:..:|           |...:
  Rat   630 GNEACESKDGIDNVDMSSKDSGSSLIRRRSTRKSIRGPHDQDGELSTKE-----------ALDDD 683

  Fly   707 APPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYPAFAVIFGEFYAALAEKD-PEDALR 770
            .||      .:|.|||:|...||.|.::|...|:..|.|.|||::||.:......:.| ||...:
  Rat   684 VPP------ASFWRILKLNSTEWPYFVVGVFCAIINGGLQPAFSIIFSKVVGVFTKNDTPEIQRQ 742

  Fly   771 RTAVLSWACLGLAFLTGLVCFLQTYLFNYAGIWLTTRMRAMTFNAMVNQEVGWFDDENNSVGALS 835
            .:.:.|...|.|..::.:..|||.:.|..||..||.|:|.|.|.:|:.|::.||||..|:.|||:
  Rat   743 NSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDISWFDDPKNTTGALT 807

  Fly   836 ARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYNWKLALLCLANCPIIVGSVILEAKMMS 900
            .||:.:|..::||.|..|:.:.|.::|..:.:.:::.|.|:|.||.||..|||..:.::|.||:|
  Rat   808 TRLANDAAQVKGATGSRLAVITQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLS 872

  Fly   901 NAVVREKQVIEEACRIATESITNIRTVAGLRREADVIREYTEEIQRVEVLIRQKLRWRGVLNSTM 965
            ...:::|:.:|.:.:||||:|.|.|||..|.||......|.:.:|.......:|....|:..|..
  Rat   873 GQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNALKKAHVFGITFSFT 937

  Fly   966 QASAFFAYAVALCYGGVLVSEGQLPFQDIIKVSETLLYGSMMLAQSLAFTPAFSAALIAGHRLFQ 1030
            ||..:|:||....:|..||:...:.|::::.|...:::|:|.:.|..:|.|.::.|.::...:.:
  Rat   938 QAMMYFSYAACFRFGAYLVARELMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKAKVSASHIIR 1002

  Fly  1031 ILDRKPKIQSPMGTIKNTLAKQLNLFEG-VRYRGIQFRYPTRPDAKILNGLDLEVLKGQTVALVG 1094
            |:::.|:|.|     .:|...:.|:.|| |::.|:.|.|||||:..:|.||.|||.||||:||||
  Rat  1003 IIEKIPEIDS-----YSTEGLKPNMLEGNVKFNGVMFNYPTRPNIPVLQGLSLEVKKGQTLALVG 1062

  Fly  1095 HSGCGKSTCVQLLQRYYDPDEGTIHIDHDDIQHDLTLDGVRTKLGIVSQEPTLFERSIAENIAYG 1159
            .|||||||.||||:|:|||..||:.:|..:|: .|.:..:|..||||||||.||:.|||||||||
  Rat  1063 SSGCGKSTVVQLLERFYDPMAGTVFLDGKEIK-QLNVQWLRAHLGIVSQEPILFDCSIAENIAYG 1126

  Fly  1160 DNRRSVSMVEIIAAAKSANAHSFIISLPNGYDTRMGARGTQLSGGQKQRIAIARALVRNPKILLL 1224
            ||.|.||..||:.|||.||.|.||.|||..|:||:|.:||||||||||||||||||||.|.||||
  Rat  1127 DNSRVVSHEEIVKAAKEANIHQFIDSLPEKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLL 1191

  Fly  1225 DEATSALDLQSEQLVQQALDTACSGRTCIVIAHRLSTVQNADVICVIQNGQVVEQGNHMQLISQG 1289
            ||||||||.:||::||:|||.|..|||||||||||||:||||:|.|||||||.|.|.|.||::|.
  Rat  1192 DEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGQVKEHGTHQQLLAQK 1256

  Fly  1290 GIYAKLHKTQ 1299
            |||..:...|
  Rat  1257 GIYFSMVSVQ 1266

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	238/525 (45%)
		MdlB	711..1299	CDD:440747	270/589 (46%)
Abcb1a	NP_596892.1	PTZ00265	51..1259	CDD:240339	532/1257 (42%)