Protein Alignment Mdr65 and LOC1281053

DIOPT Version :10

• Sequence 1: NP_476831.1
• Gene: Mdr65 / 38726
• FlyBaseID: FBgn0004513
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: XP_061506121.1
• Gene: LOC1281053 / 1281053
• VectorBaseID: AGAMI1_005941
• Length: 725
• Species: Anopheles gambiae
• Alignment Length: 786
• Identity: 160/786 - (20%)
• Similarity: 276/786 - (35%)
• Gaps: 285/786 - (36%)

  Fly   399 YGLRGDVEFQDVFFRYPSRPEVIVHRGLNIRIRAGQTVALVGSSGCGKSTCVQLLQRFYDPVFGS 463
            ||...|          |::..|:.|  ||:.:..|....|:|:|||||:|.:..       :.|.
Mosquito    13 YGKAND----------PNKKIVLNH--LNMSVTRGSIYGLLGASGCGKTTLLSC-------IVGR 58

  Fly   464 VLLDDLDIRKY--------------NIQWLRSNIAVVGQ----EPVLFLGTIAQNISYGKPGATQ 510
            ..|:|.:|...              .|.::..:||:|.:    |.:.:.|.| ..:|..|.....
Mosquito    59 KFLNDGEINVLGGTPGTAGSGVPGPRIGYMPQDIALVEEFTIKETIYYFGRI-YGMSKEKIRERY 122

  Fly   511 KEIEAAATQAGAHEFITNLPESYRSMIGERGSQLSGGQKQRIAIARALIQNPKILLLDEATSALD 575
            |.::......|...::.|               .||||::|::.|.|::..|::|:|||.|..||
Mosquito   123 KLLKHLLELPGDDRYVGN---------------CSGGQQRRVSFAAAMVHEPELLILDEPTVGLD 172

  Fly   576 -YQSEKQVQQALDLASKGRTTIVV-SHRLSAIRGADKIVFIHDGKVLEEGSHDDLM------ALE 632
             ...||..|..::..|..:..::: :|.:...:.|..|..:.:|.:|.|.|..:::      :||
Mosquito   173 PLLREKIWQYLVETTSTSKMAVIITTHYIEEAKQAGFIGLMRNGILLAEDSPTNILERFSCTSLE 237

  Fly   633 GAYYNMVRAGDINMPDEVEKEDSIEDTKQKSLALFEKSFETSP---LNFEKGQKNS--------- 685
            .|:.|:.:.   :.|.|.....:.:....:::|..:...:..|   .|.:|.:...
Mosquito   238 EAFLNLCQK---HGPSEEADRTTHQTATLRAIAGAQDLKKVIPALGTNEQKAKDGGGGGGGGGLF 299

  Fly   686 VQFEEPI---IKALIKDTNAQSAEAPPEKPNFFRTFSRILQLAKQEWCYLILGTISAVAVGFLYP 747
            .:..:|:   ||.|:..|:.:...|...| ||       ||:.:|....:.|         ||||
Mosquito   300 AEKRKPLTSTIKELVSFTSKRRMNALLSK-NF-------LQMIRQPAGMVFL---------FLYP 347

  Fly   748 AFAVIFGEFYAALAEKDPEDALRRTAVLSWACLGLA--FLTGL-VCFLQTYLFNYAGIWLTTRMR 809
            .|.::  .||.|:. .:|:| ||         ||:.  .||.: .||.::.:..|
Mosquito   348 IFQLV--SFYVAVG-GNPKD-LR---------LGIVNEELTNIRQCFNESLITTY---------- 389

  Fly   810 AMTFNAMVNQEVGWFDDENNSVGALSARLSGEAVDIQGAIGYPLSGMIQALSNFISSVSVAMYYN 874
                         :.:|.:..:..:|.|.                     |.....||::..||:
Mosquito   390 -------------YREDYDCDLYKVSCRF---------------------LEKLNRSVAIQEYYD 420

  Fly   875 WKLALLCLANCPIIVGSVILEAKMMSNAVVREKQVIEEACRIA---------------TESITNI 924
                                              ..|:|.|.|               |||:.::
Mosquito   421 ----------------------------------TYEDAYRDARKGKILGFIHFSENFTESLQDV 451

  Fly   925 RTVAGLRREADVIREYTEEI--------QRVEVLIRQKLRWRGVLNSTMQASAFFAYAVALCYGG 981
            |...   |:||....:|.||        |::...|.:||         :|....||.:
Mosquito   452 RDNV---RDADDGSFHTSEIKVYLDKSDQQITFFIEKKL---------LQTYREFAES------- 497

  Fly   982 VLVSEGQLPFQ--DIIKVSETLLYGSM------MLAQSLAFTPAFSAALIAGHRLFQILDRKPKI 1038
             |:::.:||.|  :|....||.:||:.      .:|..:..|..|..|.:....:| |.||
Mosquito   498 -LMTDCRLPKQLANIPITFETPVYGTFDEEFTDFMAPGVVMTMIFFLATLITATIF-ITDR---- 556

  Fly  1039 QSPMGTIKNTLAKQLNLFEGVRYRGIQFRYPTRPDAKILNGLD-LEVLKGQTVALVGHSGCGKST 1102
                             .|||.            |..|:.|:. ||:|....:.         .|
Mosquito   557 -----------------LEGVW------------DRTIVAGITALELLLAHIIT---------QT 583

  Fly  1103 CVQLLQ 1108
            .:.|||
Mosquito   584 SIMLLQ 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr65	NP_476831.1	MdlB	118..641	CDD:440747	63/267 (24%)
		MdlB	711..1299	CDD:440747	85/433 (20%)
LOC1281053	XP_061506121.1	None